Homologous Recombination Deficiency: Concepts, Definitions, and Assays

• Published in: The oncologist (Dayton, Ohio) Vol. 27; no. 3; pp. 167 - 174
• Main Authors: Stewart, Mark D, Merino Vega, Diana, Arend, Rebecca C, Baden, Jonathan F, Barbash, Olena, Beaubier, Nike, Collins, Grace, French, Tim, Ghahramani, Negar, Hinson, Patsy, Jelinic, Petar, Marton, Matthew J, McGregor, Kimberly, Parsons, Jerod, Ramamurthy, Lakshman, Sausen, Mark, Sokol, Ethan S, Stenzinger, Albrecht, Stires, Hillary, Timms, Kirsten M, Turco, Diana, Wang, Iris, Williams, J Andrew, Wong-Ho, Elaine, Allen, Jeff
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 11.03.2022
• Subjects: Adenosine triphosphatase; Biotechnology; Biotechnology industry; BRCA1 Protein - genetics; Cancer; Cancer Diagnostics and Molecular Pathology; Chemotherapy; Chromosomal instability syndromes; Diagnosis; DNA Repair; Drug therapy; Female; Genes; Genetic aspects; Health aspects; Homologous Recombination - genetics; Humans; Monosaccharides; Ovarian cancer; Ovarian Neoplasms - drug therapy; Pharmaceutical industry; Physiological aspects; Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use; Poly(ADP-ribose) Polymerases - genetics; Recombinational DNA Repair - genetics; Sugars; Tumors; United States; United Kingdom; homologous recombination; poly(ADP-ribose) polymerase inhibitors; DNA repair; biomarkers; tumor; BRCA1; BRCA2

Abstract Background Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors t...