MicroRNA biogenesis: regulating the regulators

• Published in: Critical reviews in biochemistry and molecular biology Vol. 48; no. 1; pp. 51 - 68
• Main Authors: Finnegan, Emily F., Pasquinelli, Amy E.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.01.2013; Taylor & Francis
• Subjects: Animals; Argonaute; Argonaute Proteins - metabolism; Dicer; Drosha; Gene Expression Regulation; Humans; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; mirtron; Ribonuclease III - metabolism; Transcription, Genetic

MicroRNAs (miRNAs) function as 21-24 nucleotide guide RNAs that use partial base-pairing to recognize target messenger RNAs and repress their expression. As a large fraction of protein-coding genes are under miRNA control, production of the appropriate level of specific miRNAs at the right time and...