Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against ac...
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| Published in | Molecules (Basel, Switzerland) Vol. 24; no. 1; p. 131 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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31.12.2018
MDPI |
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| Online Access | Get full text |
| ISSN | 1420-3049 1420-3049 |
| DOI | 10.3390/molecules24010131 |
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| Abstract | Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries. |
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| AbstractList | Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries.Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries. Baicalein (BAI), one of the main components of , possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries. Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi , possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries. Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and anti-bacterial activities. The purpose of this study was to evaluate the hepatoprotective effect of baicalein against acetaminophen (APAP)-exposed liver injury in mice, and elucidate the underlying hepatoprotective mechanism. Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1β and TNF-α in serum and hepatic in a dose-dependent manner. It also dose-dependently reduced the hepatic malondialdehyde (MDA) concentration, as well as the depletion of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH) and hepatic catalase (CAT). Moreover, pretreatment with baicalein significantly ameliorated APAP-exposed liver damage and histological hepatocyte changes. Baicalein also relieved APAP-induced autophagy by regulating AKT/mTOR pathway, LC3B and P62 expression. Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway. Taken together, our findings suggested that baicalein exhibits the ability to prevent liver from APAP-induced liver injury and provided an underlying molecular basis for potential applications of baicalein to cure liver injuries. |
| Author | Zong, Ying Du, Rui Wang, Hui Li, Jian-Ming Zhou, Hong-Chao Shi, Kun |
| AuthorAffiliation | College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; zhouhongchao813716@126.com (H.-C.Z.); wanghui813716@126.com (H.W.); sk1981521@jlau.edu.cn (K.S.); lijianming4773@163.com (J.-M.L.) |
| AuthorAffiliation_xml | – name: College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; zhouhongchao813716@126.com (H.-C.Z.); wanghui813716@126.com (H.W.); sk1981521@jlau.edu.cn (K.S.); lijianming4773@163.com (J.-M.L.) |
| Author_xml | – sequence: 1 givenname: Hong-Chao surname: Zhou fullname: Zhou, Hong-Chao – sequence: 2 givenname: Hui surname: Wang fullname: Wang, Hui – sequence: 3 givenname: Kun surname: Shi fullname: Shi, Kun – sequence: 4 givenname: Jian-Ming surname: Li fullname: Li, Jian-Ming – sequence: 5 givenname: Ying surname: Zong fullname: Zong, Ying – sequence: 6 givenname: Rui surname: Du fullname: Du, Rui |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30602693$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41598-018-35817-2 10.1016/j.molp.2017.08.009 10.1093/toxsci/kfy002 10.1016/j.intimp.2018.05.011 10.1002/ptr.1216 10.1016/j.ymeth.2014.11.021 10.1016/j.taap.2011.03.001 10.1002/hep.21095 10.1016/j.cell.2016.09.030 10.1142/S0192415X17500318 10.1016/j.bcp.2009.12.019 10.3389/fimmu.2016.00163 10.1007/s11434-016-1136-5 10.1159/000493655 10.1016/j.intimp.2017.12.002 10.1124/jpet.110.176321 10.1038/s41598-017-15521-3 10.1016/j.cgh.2017.11.042 10.1080/14740338.2018.1491547 10.1111/liv.13866 10.1006/phrs.2000.0761 10.1002/jat.3609 10.1016/j.jhep.2014.05.033 10.1016/j.jhep.2016.11.017 10.7150/thno.25798 10.1016/j.biopha.2018.10.160 10.1136/gutjnl-2015-310341 10.1016/j.tox.2016.01.004 10.1002/hep.25982 10.1158/0008-5472.CAN-03-3959 10.1021/acs.jafc.7b00610 10.1016/j.biopha.2018.08.082 10.1111/eci.12141 10.1016/j.redox.2018.04.019 10.1002/hep.26625 10.1158/1078-0432.CCR-12-2777 10.1080/15563650.2017.1408812 10.1016/j.jhep.2016.04.025 10.1016/j.tiv.2011.04.022 10.1016/j.redox.2016.10.001 10.1016/j.bbcan.2018.04.010 10.1016/j.cbi.2017.09.007 10.1016/j.toxlet.2016.11.012 10.1016/j.taap.2012.08.015 10.1016/j.cellsig.2014.04.009 10.3109/03602532.2011.602688 10.1080/15563650802665587 10.1016/j.jep.2016.10.078 10.1016/j.biopha.2017.12.076 10.1007/s00011-013-0639-7 10.4103/0973-1482.235356 10.1016/j.dld.2017.08.023 |
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| Copyright | 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 by the authors. 2018 |
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| Keywords | acetaminophen liver injury baicalein autophagy inflammation |
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| References | McGreal (ref_8) 2018; 162 Rahimian (ref_24) 2013; 43 Qi (ref_38) 2013; 62 Yin (ref_44) 2019; 109 Lee (ref_10) 2018; 38 Bochorakova (ref_16) 2003; 17 Agarwal (ref_32) 2010; 337 Chao (ref_28) 2018; 38 Hoofnagle (ref_2) 2015; 63 McGill (ref_26) 2012; 264 Jaeschke (ref_13) 2012; 44 Moscat (ref_48) 2016; 167 Woolbright (ref_25) 2016; 66 Duan (ref_53) 2016; 341–343 Li (ref_35) 2018; 16 Silver (ref_36) 2004; 64 Yim (ref_57) 2016; 194 Ni (ref_50) 2016; 65 McNulty (ref_14) 2018; 56 Gao (ref_19) 2001; 43 Xu (ref_30) 2017; 65 Xu (ref_39) 2017; 7 Formica (ref_1) 2018; 17 Liang (ref_33) 2018; 98 Mo (ref_52) 2018; 8 Nguyen (ref_42) 2017; 277 Huang (ref_9) 2018; 50 Yan (ref_4) 2018; 17 Watkins (ref_7) 2006; 43 He (ref_23) 2018; 14 Yang (ref_41) 2018; 15 Muhl (ref_37) 2016; 7 Rubin (ref_6) 2018; 16 Zhao (ref_18) 2018; 11 Wang (ref_34) 2013; 57 Morgillo (ref_21) 2013; 19 Uchida (ref_31) 2017; 45 Getachew (ref_3) 2010; 79 Gong (ref_20) 2018; 8 Wang (ref_40) 2017; 265 Li (ref_43) 2018; 16 Saberi (ref_55) 2014; 59 Lin (ref_51) 2014; 61 Du (ref_12) 2016; 10 Zhao (ref_17) 2016; 61 Yin (ref_22) 2018; 55 Herndon (ref_5) 2014; 28 Letelier (ref_11) 2011; 25 Fan (ref_54) 2018; 49 Whelan (ref_46) 2017; 66 Xu (ref_56) 2014; 26 Sandilands (ref_15) 2009; 47 Fu (ref_45) 2018; 107 Wang (ref_29) 2018; 61 Jiang (ref_47) 2015; 75 Shelton (ref_49) 2018; 1870 Williams (ref_27) 2011; 252 |
| References_xml | – volume: 8 start-page: 17412 year: 2018 ident: ref_20 article-title: Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages publication-title: Sci. Rep. doi: 10.1038/s41598-018-35817-2 – volume: 11 start-page: 135 year: 2018 ident: ref_18 article-title: Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4′-Deoxyflavones in Scutellaria baicalensis publication-title: Mol. Plant doi: 10.1016/j.molp.2017.08.009 – volume: 162 start-page: 599 year: 2018 ident: ref_8 article-title: Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfy002 – volume: 61 start-page: 20 year: 2018 ident: ref_29 article-title: Inhibition of acetaminophen-induced hepatotoxicity in mice by exogenous thymosinbeta4 treatment publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2018.05.011 – volume: 17 start-page: 640 year: 2003 ident: ref_16 article-title: Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties publication-title: Phytother. Res. doi: 10.1002/ptr.1216 – volume: 75 start-page: 13 year: 2015 ident: ref_47 article-title: LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells publication-title: Methods doi: 10.1016/j.ymeth.2014.11.021 – volume: 252 start-page: 2892 year: 2011 ident: ref_27 article-title: Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2011.03.001 – volume: 43 start-page: 618 year: 2006 ident: ref_7 article-title: Drug-induced liver injury: Summary of a single topic clinical research conference publication-title: Hepatology doi: 10.1002/hep.21095 – volume: 167 start-page: 606 year: 2016 ident: ref_48 article-title: p62 in Cancer: Signaling Adaptor Beyond Autophagy publication-title: Cell doi: 10.1016/j.cell.2016.09.030 – volume: 45 start-page: 515 year: 2017 ident: ref_31 article-title: Protective Effect of Cymbopogon citratus Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury publication-title: Am. J. Chin. Med. doi: 10.1142/S0192415X17500318 – volume: 79 start-page: 1363 year: 2010 ident: ref_3 article-title: Susceptibility to acetaminophen (apap) toxicity unexpectedly is decreased during acute viral hepatitis in mice publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2009.12.019 – volume: 7 start-page: 163 year: 2016 ident: ref_37 article-title: STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation—The Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00163 – volume: 61 start-page: 1391 year: 2016 ident: ref_17 article-title: Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants publication-title: Sci. Bull. doi: 10.1007/s11434-016-1136-5 – volume: 63 start-page: 590 year: 2015 ident: ref_2 article-title: Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports publication-title: Hepatology – volume: 49 start-page: 1943 year: 2018 ident: ref_54 article-title: Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3beta Pathway publication-title: Cell Physiol. Biochem. doi: 10.1159/000493655 – volume: 55 start-page: 55 year: 2018 ident: ref_22 article-title: Baicalein improves liver inflammation in diabetic db/db mice by regulating HMGB1/TLR4/NF-kappaB signaling pathway publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2017.12.002 – volume: 337 start-page: 110 year: 2010 ident: ref_32 article-title: Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase publication-title: J. Pharmacol. Exper. Ther. doi: 10.1124/jpet.110.176321 – volume: 7 start-page: 15175 year: 2017 ident: ref_39 article-title: The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: Focusing MAPK pathway activity publication-title: Sci. Rep. doi: 10.1038/s41598-017-15521-3 – volume: 16 start-page: 936 year: 2018 ident: ref_6 article-title: Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2017.11.042 – volume: 17 start-page: 681 year: 2018 ident: ref_1 article-title: The economic burden of preventable adverse drug reactions: A systematic review of observational studies publication-title: Expert Opin. Drug Saf. doi: 10.1080/14740338.2018.1491547 – volume: 38 start-page: 1363 year: 2018 ident: ref_28 article-title: Role and mechanisms of autophagy in acetaminophen-induced liver injury publication-title: Liver Int. doi: 10.1111/liv.13866 – volume: 43 start-page: 173 year: 2001 ident: ref_19 article-title: Protective effects of flavonoids in the roots of scutellaria baicalensis georgi against hydrogen peroxide-induced oxidative stress in hs-sy5y cells publication-title: Pharmacol. Res. doi: 10.1006/phrs.2000.0761 – volume: 38 start-page: 1008 year: 2018 ident: ref_10 article-title: Exogenous recombinant human thioredoxin-1 prevents acetaminophen-induced liver injury by scavenging oxidative stressors, restoring the thioredoxin-1 system and inhibiting receptor interacting protein-3 overexpression publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3609 – volume: 61 start-page: 825 year: 2014 ident: ref_51 article-title: Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice publication-title: J. Hepatol. doi: 10.1016/j.jhep.2014.05.033 – volume: 66 start-page: 836 year: 2016 ident: ref_25 article-title: Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.11.017 – volume: 15 start-page: 2228 year: 2018 ident: ref_41 article-title: Hepatoprotective effect of methyl ferulic acid against carbon tetrachloride-induced acute liver injury in rats publication-title: Exp. Ther. Med. – volume: 8 start-page: 4170 year: 2018 ident: ref_52 article-title: Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury publication-title: Theranostics doi: 10.7150/thno.25798 – volume: 109 start-page: 493 year: 2019 ident: ref_44 article-title: Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice publication-title: Biomed. Pharmacothr. doi: 10.1016/j.biopha.2018.10.160 – volume: 66 start-page: 1197 year: 2017 ident: ref_46 article-title: Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis publication-title: Gut doi: 10.1136/gutjnl-2015-310341 – volume: 341–343 start-page: 28 year: 2016 ident: ref_53 article-title: 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways publication-title: Toxicology doi: 10.1016/j.tox.2016.01.004 – volume: 57 start-page: 373 year: 2013 ident: ref_34 article-title: High-mobility group box 1 (hmgb1)-toll-like receptor (tlr)4-interleukin (il)-23-il-17a axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ t cells with macrophages publication-title: Hepatology doi: 10.1002/hep.25982 – volume: 64 start-page: 3550 year: 2004 ident: ref_36 article-title: Activated signal transducer and activator of transcription (STAT) 3: Localization in focal adhesions and function in ovarian cancer cell motility publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-03-3959 – volume: 65 start-page: 3684 year: 2017 ident: ref_30 article-title: Saponins (Ginsenosides) from the Leaves of Panax quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice publication-title: J. Agric. Food. Chem. doi: 10.1021/acs.jafc.7b00610 – volume: 107 start-page: 867 year: 2018 ident: ref_45 article-title: Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.08.082 – volume: 28 start-page: 109 year: 2014 ident: ref_5 article-title: Patient perception and knowledge of acetaminophen in a large family medicine service. J. Pain Palliat publication-title: Care Pharmacother. – volume: 43 start-page: 1039 year: 2013 ident: ref_24 article-title: Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats publication-title: Eur. J. Clin. Investig. doi: 10.1111/eci.12141 – volume: 17 start-page: 274 year: 2018 ident: ref_4 article-title: Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions publication-title: Redox Biol. doi: 10.1016/j.redox.2018.04.019 – volume: 59 start-page: 1543 year: 2014 ident: ref_55 article-title: Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways publication-title: Hepatology doi: 10.1002/hep.26625 – volume: 19 start-page: 3508 year: 2013 ident: ref_21 article-title: Synergistic effects of metformin treatment in combination with gefitinib, a selective egfr tyrosine kinase inhibitor, in lkb1 wild-type nsclc cell lines publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-2777 – volume: 56 start-page: 618 year: 2018 ident: ref_14 article-title: Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose publication-title: Clin. Toxicol. doi: 10.1080/15563650.2017.1408812 – volume: 65 start-page: 354 year: 2016 ident: ref_50 article-title: Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.04.025 – volume: 25 start-page: 1310 year: 2011 ident: ref_11 article-title: Microsomal oxidative damage promoted by acetaminophen metabolism publication-title: Toxicol. Vitro doi: 10.1016/j.tiv.2011.04.022 – volume: 10 start-page: 148 year: 2016 ident: ref_12 article-title: Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential publication-title: Redox Biol. doi: 10.1016/j.redox.2016.10.001 – volume: 16 start-page: 2013 year: 2018 ident: ref_35 article-title: Effect of JAK2/STAT3 signaling pathway on liver injury associated with severe acute pancreatitis in rats publication-title: Exp. Ther. Med. – volume: 1870 start-page: 88 year: 2018 ident: ref_49 article-title: Metabolic reprogramming of the tumor microenvironment by p62 and its partners publication-title: Biochem. Biophys. Acta Rev. Cancer doi: 10.1016/j.bbcan.2018.04.010 – volume: 277 start-page: 129 year: 2017 ident: ref_42 article-title: Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2017.09.007 – volume: 265 start-page: 38 year: 2017 ident: ref_40 article-title: Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2016.11.012 – volume: 264 start-page: 387 year: 2012 ident: ref_26 article-title: Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2012.08.015 – volume: 26 start-page: 1680 year: 2014 ident: ref_56 article-title: Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson’s disease publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2014.04.009 – volume: 44 start-page: 88 year: 2012 ident: ref_13 article-title: Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity publication-title: Drug Metab. Rev. doi: 10.3109/03602532.2011.602688 – volume: 47 start-page: 81 year: 2009 ident: ref_15 article-title: Adverse reactions associated with acetylcysteine publication-title: Clin. Toxicol. doi: 10.1080/15563650802665587 – volume: 194 start-page: 1060 year: 2016 ident: ref_57 article-title: A platycoside-rich fraction from the root of Platycodon grandiflorum enhances cell death in A549 human lung carcinoma cells via mainly AMPK/mTOR/AKT signal-mediated autophagy induction publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2016.10.078 – volume: 98 start-page: 916 year: 2018 ident: ref_33 article-title: Simvastatin protects against acetaminophen-induced liver injury in mice publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.12.076 – volume: 62 start-page: 845 year: 2013 ident: ref_38 article-title: Baicalein reduces lipopolysaccharide-induced inflammation via suppressing jak/stats activation and ros production publication-title: Inflamm. Res. doi: 10.1007/s00011-013-0639-7 – volume: 14 start-page: S519 year: 2018 ident: ref_23 article-title: Baicalein and Ly294002 induces liver cancer cells apoptosis via regulating phosphatidyl inositol 3-kinase/Akt signaling pathway publication-title: J. Cancer Res. Ther. doi: 10.4103/0973-1482.235356 – volume: 50 start-page: 175 year: 2018 ident: ref_9 article-title: Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice publication-title: Dig. Liver Dis. doi: 10.1016/j.dld.2017.08.023 – volume: 16 start-page: 700 year: 2018 ident: ref_43 article-title: Protective effects of extracts of Schisandra chinensis stems against acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways publication-title: Chin. J. Nat. Med. |
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| SubjectTerms | acetaminophen Analgesics Autophagy baicalein Cytokines Drug dosages Drug overdose Inflammation Kidneys Kinases Liver liver injury Metabolism Metabolites Oxidative stress Phosphorylation Proteins |
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| Title | Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice |
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