Stabilization of TM Trimer Interactions during Activation of Moloney Murine Leukemia Virus Env

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 82; no. 5; pp. 2358 - 2366
Main Authors Sjöberg, Mathilda, Lindqvist, Birgitta, Garoff, Henrik
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.03.2008
American Society for Microbiology (ASM)
Subjects
Biological and medical sciences
Biopolymers - metabolism
Cell Line
Disulfides - metabolism
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Gene Products, env - chemistry
Gene Products, env - metabolism
Isomerism
Medicin och hälsovetenskap
Microbiology
Miscellaneous
Moloney murine leukemia virus
Moloney murine leukemia virus - metabolism
Protein Conformation
Protein Folding
Retrovirus
Virology
Virus-Cell Interactions
Virus
Retroviridae
Gammaretrovirus
Interaction
Moloney murine leukemia virus
Virology
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList The transmembrane subunit (TM) of the trimeric retrovirus Env complex is thought to direct virus-cell membrane fusion by refolding into a cell membrane-interacting, extended form that subsequently folds back on itself into a very stable trimer of hairpin-like TM polypeptides. However, so far there is only limited evidence for the formation of a stable TM trimer during Env activation. Here we have studied the oligomer composition and stability of an intermediate and the fully activated form of Moloney murine leukemia virus (Mo-MLV) Env. Activation of Mo-MLV Env is controlled by isomerization of its intersubunit disulfide. This results in surface subunit (SU) dissociation and TM refolding. If activation is done in the presence of an alkylator, this will modify the isomerization-active thiol in the SU of Env and arrest Env at an intermediate stage, the isomerization-arrested state (IAS) of its activation pathway. We generated IAS and fully activated Envs in vitro and in vivo and studied their states of oligomerization by two-dimensional blue native polyacrylamide gel electrophoresis (PAGE) and nonreducing sodium dodecyl sulfate (SDS)-PAGE. The IAS Env was composed of trimers of SU-TM complexes, whereas the activated Env consisted of SU monomers and TM trimers. When the oligomers were subjected to mild SDS treatment the TM trimer was found to be 3.5 times more resistant than the IAS oligomer. Thus, this demonstrates that a structural conversion of TM takes place during activation, which results in the formation of a stable TM trimer.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
ABSTRACT The transmembrane subunit (TM) of the trimeric retrovirus Env complex is thought to direct virus-cell membrane fusion by refolding into a cell membrane-interacting, extended form that subsequently folds back on itself into a very stable trimer of hairpin-like TM polypeptides. However, so far there is only limited evidence for the formation of a stable TM trimer during Env activation. Here we have studied the oligomer composition and stability of an intermediate and the fully activated form of Moloney murine leukemia virus (Mo-MLV) Env. Activation of Mo-MLV Env is controlled by isomerization of its intersubunit disulfide. This results in surface subunit (SU) dissociation and TM refolding. If activation is done in the presence of an alkylator, this will modify the isomerization-active thiol in the SU of Env and arrest Env at an intermediate stage, the isomerization-arrested state (IAS) of its activation pathway. We generated IAS and fully activated Envs in vitro and in vivo and studied their states of oligomerization by two-dimensional blue native polyacrylamide gel electrophoresis (PAGE) and nonreducing sodium dodecyl sulfate (SDS)-PAGE. The IAS Env was composed of trimers of SU-TM complexes, whereas the activated Env consisted of SU monomers and TM trimers. When the oligomers were subjected to mild SDS treatment the TM trimer was found to be 3.5 times more resistant than the IAS oligomer. Thus, this demonstrates that a structural conversion of TM takes place during activation, which results in the formation of a stable TM trimer.
Author Henrik Garoff
Birgitta Lindqvist
Mathilda Sjöberg
AuthorAffiliation Department of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden
AuthorAffiliation_xml – name: Department of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden
Author_xml – sequence: 1
  givenname: Mathilda
  surname: Sjöberg
  fullname: Sjöberg, Mathilda
  organization: Department of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden
– sequence: 2
  givenname: Birgitta
  surname: Lindqvist
  fullname: Lindqvist, Birgitta
– sequence: 3
  givenname: Henrik
  surname: Garoff
  fullname: Garoff, Henrik
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20192352$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18094169$$D View this record in MEDLINE/PubMed
http://kipublications.ki.se/Default.aspx?queryparsed=id:116652144$$DView record from Swedish Publication Index
BookMark eNqFkU1vEzEQhi1URNPCjTMyBzixxR9rx75UqqoCQYk4ECpOWF7vbOJ2P4q9m6r8erxkFeiJg2WP55nXM35P0FHbtYDQS0rOKGXq_efrxRmhmtOMzJ-gGSVaZULQ_AjNCGEsE1x9P0YnMd4QQvNc5s_QMVVE51TqGfrxtbeFr_0v2_uuxV2F1yu8Dr6BgBdtD8G6MRFxOQTfbvBFCncHdtXVqZkHvBqTgJcw3ELjLb72YYj4qt09R08rW0d4Me2n6NuHq_Xlp2z55ePi8mKZOUF1n1FdKU6klqRQDoSyoC0oUnBlZVHygueqyAtZcCC5LS3XJKdQVdLZkinnCn6K9F433sPdUJi7NIEND6azPp270kz3t35cJoKhVErB0oek2vN9bQIaKB20fbD1Y4lHmdZvzabbGcaESi0ngbeTQOh-DhB70_jooK5tC90QzZwwpbVk_wUZEVwQPYLv9qALXYwBqkM3lJjRdZNcN39cN2Se8Ff_TvAXnmxOwJsJsNHZugq2dT4eOJaUGBfju6_33NZvtvc-gLGxMTc7bxQzwiRG8d_25sTR
CitedBy_id crossref_primary_10_1080_15592324_2019_1596719
crossref_primary_10_1016_j_virusres_2013_04_014
crossref_primary_10_1128_JVI_00748_09
crossref_primary_10_1074_jbc_M806725200
crossref_primary_10_3390_v11060497
crossref_primary_10_1073_pnas_1118125109
crossref_primary_10_1073_pnas_1617264114
crossref_primary_10_1038_emboj_2008_187
crossref_primary_10_1080_21645515_2019_1649532
crossref_primary_10_1128_JVI_02500_10
Cites_doi 10.1099/0022-1317-69-11-2785
10.1016/S0092-8674(00)00170-7
10.1083/jcb.139.6.1455
10.1073/pnas.94.26.14306
10.1128/JVI.78.15.8201-8209.2004
10.1016/0042-6822(74)90187-1
10.1128/jvi.71.10.8073-8077.1997
10.1128/JVI.80.5.2515-2528.2006
10.1128/jvi.66.8.4940-4950.1992
10.1146/annurev.biochem.69.1.531
10.1073/pnas.92.26.12205
10.1128/jvi.64.3.1233-1240.1990
10.1002/j.1460-2075.1992.tb05305.x
10.1128/JVI.78.3.1403-1410.2004
10.1006/viro.1995.1250
10.1016/S0960-9822(95)00275-2
10.1038/nature04322
10.1073/pnas.96.8.4319
10.1038/289366a0
10.1128/JVI.79.3.1678-1685.2005
10.1128/JVI.00380-06
10.1073/pnas.0409178102
10.1016/0092-8674(92)90140-8
10.1128/jvi.68.4.2772-2776.1994
10.1128/JVI.72.8.6537-6545.1998
10.1016/0003-2697(91)90094-A
10.1006/viro.1996.0315
10.1128/jvi.66.2.865-874.1992
10.1016/S0092-8674(00)80205-6
10.1038/nsb0596-465
10.1038/371037a0
10.1038/nsb0498-276
10.1128/JVI.73.11.9683-9689.1999
10.1128/JVI.78.24.13430-13439.2004
10.1038/sj.emboj.7600012
10.1038/360358a0
10.1128/JVI.79.22.13856-13864.2005
10.1128/JVI.01851-05
ContentType Journal Article
Copyright 2008 INIST-CNRS
Copyright © 2008, American Society for Microbiology
Copyright_xml – notice: 2008 INIST-CNRS
– notice: Copyright © 2008, American Society for Microbiology
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7U9
H94
7X8
5PM
ADTPV
AOWAS
D8T
ZZAVC
DOI 10.1128/JVI.01931-07
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
SwePub
SwePub Articles
SWEPUB Freely available online
SwePub Articles full text
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
AIDS and Cancer Research Abstracts
Virology and AIDS Abstracts
MEDLINE - Academic
DatabaseTitleList AIDS and Cancer Research Abstracts

MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 2366
ExternalDocumentID oai_prod_swepub_kib_ki_se_116652144
10_1128_JVI_01931_07
18094169
20192352
jvi_82_5_2358
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.GJ
08R
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAUGY
AAYJJ
ABPPZ
ABPTK
ACGFO
ACNCT
ADBBV
AENEX
AFDAS
AFFNX
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
D0S
DIK
E3Z
EBS
EJD
F20
F5P
FRP
GX1
H13
HYE
HZ~
IH2
IQODW
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UCJ
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
XFK
Y6R
YQT
ZA5
ZGI
ZXP
~02
~KM
AGVNZ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7U9
H94
7X8
5PM
ADTPV
AOWAS
D8T
ZZAVC
ID FETCH-LOGICAL-c519t-19f8306960b8ce58ae9ae80b38a6bd3b348b4b6b3e04ada39041eff6cad28ccb3
IEDL.DBID RPM
ISSN 0022-538X
1098-5514
IngestDate Sun Oct 27 03:39:07 EDT 2024
Tue Sep 17 21:22:31 EDT 2024
Fri Oct 25 22:55:07 EDT 2024
Fri Oct 25 03:24:52 EDT 2024
Thu Sep 12 17:35:51 EDT 2024
Sat Sep 28 07:52:37 EDT 2024
Sun Oct 22 16:05:51 EDT 2023
Wed May 18 15:25:37 EDT 2016
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Virus
Retroviridae
Gammaretrovirus
Interaction
Moloney murine leukemia virus
Virology
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c519t-19f8306960b8ce58ae9ae80b38a6bd3b348b4b6b3e04ada39041eff6cad28ccb3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Corresponding author. Mailing address: Department of Biosciences and Nutrition, Karolinska Institute, S-141 57 Huddinge, Sweden. Phone: 46-8-6089125. Fax: 46-8-7745538. E-mail: henrik.garoff@cbt.ki.se
OpenAccessLink http://kipublications.ki.se/Default.aspx?queryparsed=id:116652144
PMID 18094169
PQID 20535092
PQPubID 23462
PageCount 9
ParticipantIDs proquest_miscellaneous_70289962
pubmed_primary_18094169
pubmedcentral_primary_oai_pubmedcentral_nih_gov_2258960
proquest_miscellaneous_20535092
crossref_primary_10_1128_JVI_01931_07
highwire_asm_jvi_82_5_2358
pascalfrancis_primary_20192352
swepub_primary_oai_prod_swepub_kib_ki_se_116652144
PublicationCentury 2000
PublicationDate 2008-03-01
PublicationDateYYYYMMDD 2008-03-01
PublicationDate_xml – month: 03
  year: 2008
  text: 2008-03-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2008
Publisher American Society for Microbiology
American Society for Microbiology (ASM)
Publisher_xml – name: American Society for Microbiology
– name: American Society for Microbiology (ASM)
References 11106737 - Cell. 2000 Nov 10;103(4):679-89
1812789 - Anal Biochem. 1991 Dec;199(2):223-31
3183628 - J Gen Virol. 1988 Nov;69 ( Pt 11):2785-95
9546217 - Nat Struct Biol. 1998 Apr;5(4):276-9
15650193 - J Virol. 2005 Feb;79(3):1678-85
16973599 - J Virol. 2006 Oct;80(19):9921-5
15774580 - Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4729-34
9108481 - Cell. 1997 Apr 18;89(2):263-73
1360148 - Nature. 1992 Nov 26;360(6402):358-61
16397490 - Nature. 2006 Jan 5;439(7072):38-44
8139055 - J Virol. 1994 Apr;68(4):2772-6
8612078 - Nat Struct Biol. 1996 May;3(5):465-9
10966468 - Annu Rev Biochem. 2000;69:531-69
9396751 - J Cell Biol. 1997 Dec 15;139(6):1455-64
9405608 - Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14306-13
2304141 - J Virol. 1990 Mar;64(3):1233-40
15564453 - J Virol. 2004 Dec;78(24):13430-9
8072525 - Nature. 1994 Sep 1;371(6492):37-43
8749390 - Curr Biol. 1995 Dec 1;5(12):1377-83
4361457 - Virology. 1974 Feb;57(2):475-90
1370559 - J Virol. 1992 Feb;66(2):865-74
8661378 - Virology. 1996 Jun 15;220(2):274-84
16254321 - J Virol. 2005 Nov;79(22):13856-64
16474158 - J Virol. 2006 Mar;80(5):2515-28
14685283 - EMBO J. 2004 Jan 14;23(1):54-65
1739972 - Cell. 1992 Feb 21;68(4):635-45
7747476 - Virology. 1995 May 10;209(1):242-9
10200260 - Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4319-24
7464906 - Nature. 1981 Jan 29;289(5796):366-73
16699035 - J Virol. 2006 Jun;80(11):5540-51
9658097 - J Virol. 1998 Aug;72(8):6537-45
10516085 - J Virol. 1999 Nov;73(11):9683-9
8618870 - Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12205-9
9311907 - J Virol. 1997 Oct;71(10):8073-7
14722295 - J Virol. 2004 Feb;78(3):1403-10
1629960 - J Virol. 1992 Aug;66(8):4940-50
1628614 - EMBO J. 1992 Jul;11(7):2407-14
15254191 - J Virol. 2004 Aug;78(15):8201-9
e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
(e_1_3_2_14_2) 1997
e_1_3_2_40_2
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_24_2
e_1_3_2_25_2
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_2_2
e_1_3_2_35_2
References_xml – ident: e_1_3_2_27_2
  doi: 10.1099/0022-1317-69-11-2785
– ident: e_1_3_2_22_2
  doi: 10.1016/S0092-8674(00)00170-7
– ident: e_1_3_2_13_2
  doi: 10.1083/jcb.139.6.1455
– ident: e_1_3_2_3_2
  doi: 10.1073/pnas.94.26.14306
– ident: e_1_3_2_20_2
  doi: 10.1128/JVI.78.15.8201-8209.2004
– ident: e_1_3_2_29_2
  doi: 10.1016/0042-6822(74)90187-1
– ident: e_1_3_2_26_2
  doi: 10.1128/jvi.71.10.8073-8077.1997
– ident: e_1_3_2_21_2
  doi: 10.1128/JVI.80.5.2515-2528.2006
– ident: e_1_3_2_16_2
  doi: 10.1128/jvi.66.8.4940-4950.1992
– ident: e_1_3_2_31_2
  doi: 10.1146/annurev.biochem.69.1.531
– ident: e_1_3_2_5_2
  doi: 10.1073/pnas.92.26.12205
– ident: e_1_3_2_18_2
  doi: 10.1128/jvi.64.3.1233-1240.1990
– ident: e_1_3_2_33_2
  doi: 10.1002/j.1460-2075.1992.tb05305.x
– ident: e_1_3_2_32_2
  doi: 10.1128/JVI.78.3.1403-1410.2004
– ident: e_1_3_2_38_2
  doi: 10.1006/viro.1995.1250
– ident: e_1_3_2_8_2
  doi: 10.1016/S0960-9822(95)00275-2
– ident: e_1_3_2_40_2
  doi: 10.1038/nature04322
– ident: e_1_3_2_17_2
  doi: 10.1073/pnas.96.8.4319
– start-page: 71
  year: 1997
  ident: e_1_3_2_14_2
  publication-title: Retroviruses
– ident: e_1_3_2_39_2
  doi: 10.1038/289366a0
– ident: e_1_3_2_34_2
  doi: 10.1128/JVI.79.3.1678-1685.2005
– ident: e_1_3_2_36_2
  doi: 10.1128/JVI.00380-06
– ident: e_1_3_2_9_2
  doi: 10.1073/pnas.0409178102
– ident: e_1_3_2_11_2
  doi: 10.1016/0092-8674(92)90140-8
– ident: e_1_3_2_25_2
  doi: 10.1128/jvi.68.4.2772-2776.1994
– ident: e_1_3_2_24_2
  doi: 10.1128/JVI.72.8.6537-6545.1998
– ident: e_1_3_2_28_2
  doi: 10.1016/0003-2697(91)90094-A
– ident: e_1_3_2_19_2
  doi: 10.1006/viro.1996.0315
– ident: e_1_3_2_6_2
  doi: 10.1128/jvi.66.2.865-874.1992
– ident: e_1_3_2_4_2
  doi: 10.1016/S0092-8674(00)80205-6
– ident: e_1_3_2_7_2
  doi: 10.1038/nsb0596-465
– ident: e_1_3_2_2_2
  doi: 10.1038/371037a0
– ident: e_1_3_2_10_2
  doi: 10.1038/nsb0498-276
– ident: e_1_3_2_15_2
  doi: 10.1128/JVI.73.11.9683-9689.1999
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.78.24.13430-13439.2004
– ident: e_1_3_2_35_2
  doi: 10.1038/sj.emboj.7600012
– ident: e_1_3_2_12_2
  doi: 10.1038/360358a0
– ident: e_1_3_2_37_2
  doi: 10.1128/JVI.79.22.13856-13864.2005
– ident: e_1_3_2_30_2
  doi: 10.1128/JVI.01851-05
SSID ssj0014464
Score 1.9786937
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
The transmembrane subunit (TM) of the trimeric retrovirus Env complex is thought to direct virus-cell membrane fusion by refolding into a cell...
ABSTRACT The transmembrane subunit (TM) of the trimeric retrovirus Env complex is thought to direct virus-cell membrane fusion by refolding into a cell...
SourceID swepub
pubmedcentral
proquest
crossref
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 2358
SubjectTerms Biological and medical sciences
Biopolymers - metabolism
Cell Line
Disulfides - metabolism
Electrophoresis, Polyacrylamide Gel
Fundamental and applied biological sciences. Psychology
Gene Products, env - chemistry
Gene Products, env - metabolism
Isomerism
Medicin och hälsovetenskap
Microbiology
Miscellaneous
Moloney murine leukemia virus
Moloney murine leukemia virus - metabolism
Protein Conformation
Protein Folding
Retrovirus
Virology
Virus-Cell Interactions
Title Stabilization of TM Trimer Interactions during Activation of Moloney Murine Leukemia Virus Env
URI http://jvi.asm.org/content/82/5/2358.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18094169
https://search.proquest.com/docview/20535092
https://search.proquest.com/docview/70289962
https://pubmed.ncbi.nlm.nih.gov/PMC2258960
http://kipublications.ki.se/Default.aspx?queryparsed=id:116652144
Volume 82
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEF21lZC4IL5xKWEPcHTi7IczPlZVq7YQxCGtcmK1a6-FKXGrOKnUf9_ZXW_BAnHgkEs8sZOZWe172TczhHyAvJQ11CKdmqpORcHKFIRlqbB1rZktkJB5le-X_PRCnC_lcofIWAvjRfulacbtz9W4bb57beXNqpxEndjk6_wIcxAQeU92ye6M80jR-6MD5DcitgjH1byMancGk_PLszFCGo4E2g_fA-Q2Uyd1_n1Lim2CnUpSd-ioOky4-BsE_VNJOeg36veok6fkSQ8u6WH4Ec_Ijm2fk0dh3OTdC_INkaXTwobKS3pd08WcLlx__zX1_wyGIoeOhtpFeljG2WfOdo53ae0dnbuLln622yu7ajS9bNbbjh63ty_Jxcnx4ug07ecrpCXitk06LWpAxoCeNFBaCdoW2kJmOOjcVNxwAUaY3HCbCV1pXmRiiiHMS10xKEvDX5G9Fp_8hlAEJRVzbDqzIAojCzAawGEJbiSYWUI-Rherm9BGQ3n6wUBhVJSPisrQbj_6X-lupX7cNgqYkspV9CZkNIjIw52Yx6mSJeR9DJHCVeKOPnRrr7cdWkiO0OgfFjN35FrkaPE6hPTX9-zTJCGzQbAfDFyH7uEVTFzfqbtP1ISwkBbDj-AOqfr3rxr3Up1Fl-S5dH3s9v_7cW_J46BqcUq5A7K3WW_tO4ROGzNC0nD2aeQXzD3GMhup
link.rule.ids 230,315,733,786,790,891,27946,27947,53816,53818
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfGEIIL3x8ZsPkAx6SpY6fOcZo2daOZOHRVT1i244hQmk1NO2n89Tzb8aCAkOCQS_ziOH7P8u_Fv_ceQu94rlnNaxoPVVXHtCA65tSQmJq6lsQU4JA5lu95Pr6gZ3M230EsxMI40r5WTdJ-XSZt89lxK6-WehB4YoOP5RHYIAfkPbiD7jJ78BWc9P7wADwcGpKEQ_s88N0JH5zNThMANRm40K78HgfvZmjJzj9vSiFRsOVJyg6mqvY1Lv4EQn_nUm5lHHW71MkjNAvf58kpi2SzVon-9kvqx3-egMfoYY9b8aFvfoJ2TPsU3fOVLG-eoU8AWi3N1gd14ssaT0s8taUDVtj9dPTxEx32YZH4UIeyala2hF5ac4NL22jwxGwWZtlIPGtWmw4ft9fP0cXJ8fRoHPelG2INkHAdD4uagzMCY1RcG8alKaThqcq4zFWVqYxyRVWuMpNSWcmsSOkQrCPXsiJca5W9QLstvPkVwoB3KmId9dRwWihWcCU5tzAlU4yrUYTeB92JK5-hQzjPhnAB6hZO3SIFub2gWCG7pfhy3QhOBBM2WDhC-1uqvu2JOAjMSIQOgu4FLEB7qiJbc7npQIJlgLr-IjGyp7lFDhIvva38GGdvfxEabVnRrYBN_r3dAibhkoD3JhAh4u1t-xHYfEV_f9HYS3QGpiTPmU2Rt_ffrztA98fTciImp-cfXqMHnjxjCXlv0O56tTFvAaGt1b5bj98BcfQ8pg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWgCMSlfBZSoPUBjslmHTvrHKvSVVu6VQ_basUBy3YcEZZNV5tNpfbXM7aT0gDi0EMu8cRxPGP5TfxmBqGPPNWs4AUNhyovQpoRHXJqSEhNUUhiMnDIHMv3ND08p8czNrtT6suR9rUqo-rnIqrK745buVzoQccTG5xN9sEGOSDvwTIvBg_RI2Z3nc5Rbw8QwMuhXaJwaJ91nHfCB8cXRxEAmwTcaFeCj4OHM7SE57sbU5cs2HIlZQ3TVfg6F_8Con_zKXtZR91ONX6Gvnbf6Akq86hZq0jf_JH-8V6T8BxttvgV73mRF-iBqV6ix76i5fUr9A3Aq6Xb-uBOfFng6QRPbQmBFXY_H30cRY19eCTe0115NSs7gV4qc40nttHgE9PMzaKU-KJcNTU-qK5eo_PxwXT_MGxLOIQaoOE6HGYFB6cExqm4NoxLk0nDY5Vwmao8UQnliqpUJSamMpdJFtMhWEmqZU641irZQhsVvPktwoB7cmId9thwmimWcSU5t3AlUYyrUYA-dfoTS5-pQzgPh3ABKhdO5SIGue1OuULWC_HjqhScCCZs0HCAdnrqvu2JOCjMSIB2O_0LWIj2dEVW5rKpQYIlgL7-IzGyp7pZChJvvL38HmdrgwEa9SzpVsAmAe-3gFm4ZOCtGQSIeJvrPwKbsGjvz0t7idrAlKQps6nytu_9ul305OzzWJwcnX55h556Do3l5b1HG-tVYz4AUFurHbckfwE5sD8m
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stabilization+of+TM+Trimer+Interactions+during+Activation+of+Moloney+Murine+Leukemia+Virus+Env&rft.jtitle=Journal+of+virology&rft.au=Sjoeberg%2C+Mathilda&rft.au=Lindqvist%2C+Birgitta&rft.au=Garoff%2C+Henrik&rft.date=2008-03-01&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=82&rft.issue=5&rft.spage=2358&rft.epage=2366&rft_id=info:doi/10.1128%2FJVI.01931-07&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon