The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates

• Published in: The Journal of experimental medicine Vol. 207; no. 11; pp. 2313 - 2322
• Main Authors: Tazi, Asmaa, Disson, Olivier, Bellais, Samuel, Bouaboud, Abdelouhab, Dmytruk, Nicolas, Dramsi, Shaynoor, Mistou, Michel-Yves, Khun, Huot, Mechler, Charlotte, Tardieux, Isabelle, Trieu-Cuot, Patrick, Lecuit, Marc, Poyart, Claire
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 25.10.2010; The Rockefeller University Press
• Subjects: Adhesins, Bacterial; Adhesins, Bacterial - genetics; Adhesins, Bacterial - metabolism; Animals; Bacterial Adhesion; Bacterial Adhesion - physiology; Bacterial Translocation; Bacterial Translocation - physiology; Bacteriology; Blood-Brain Barrier; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - microbiology; Brief Definitive Report; Female; HeLa Cells; Human health and pathology; Humans; Infant; Infant, Newborn; Infectious diseases; Intestinal Mucosa; Intestines; Intestines - metabolism; Intestines - microbiology; Life Sciences; Male; Meninges; Meninges - metabolism; Meninges - microbiology; Meningitis, Bacterial; Meningitis, Bacterial - genetics; Meningitis, Bacterial - metabolism; Meningitis, Bacterial - microbiology; Mice; Microbiology and Parasitology; Organ Specificity; Streptococcal Infections; Streptococcal Infections - genetics; Streptococcal Infections - metabolism; Streptococcal Infections - microbiology; Streptococcus agalactiae; Streptococcus agalactiae - pathogenicity; Streptococcus agalactiae - physiology

Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis. A single clone, GBS ST-17, is strongly associated with a deadly form of the infection called late-onset disease (LOD), which is characterized b...