Centrosome function is critical during terminal erythroid differentiation

• Published in: The EMBO journal Vol. 41; no. 14; pp. e108739 - n/a
• Main Authors: Tátrai, Péter, Gergely, Fanni
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2022; Blackwell Publishing Ltd; John Wiley and Sons Inc
• Subjects: Anemia; Anemia, Macrocytic; Animals; blood; Cell Cycle Proteins - genetics; Cell differentiation; Centrosome; Centrosomes; Chemotherapy; Chromosome Segregation; Chromosomes; Depletion; Differentiation; EMBO06; EMBO11; EMBO18; Embryo fibroblasts; Enucleation; Erythroblasts; Erythrocytes; Erythroid cells; Erythropoiesis; Fetuses; Fibroblasts; Liver; Mice; Microtubules; Mitosis; mitotic spindle; Morphology; Nutrient deficiency; p53 Protein; Progenitor cells; Reticulocytes; Spindle Apparatus - genetics; Spindles; Tetraploidy; erythropoiesis; centrosome; blood; enucleation; mitotic spindle

Red blood cells are produced by terminal erythroid differentiation, which involves the dramatic morphological transformation of erythroblasts into enucleated reticulocytes. Microtubules are important for enucleation, but it is not known if the centrosome, a key microtubule‐organizing center, is requ...