Cobalt-Catalyzed CH Cyanation of Arenes and Heteroarenes

• Published in: Angewandte Chemie International Edition Vol. 54; no. 12; pp. 3635 - 3638
• Main Authors: Li, Jie, Ackermann, Lutz
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 16.03.2015; WILEY‐VCH Verlag; Wiley
• Subjects: Activation; Aromatic compounds; Benzene Derivatives - chemistry; Carbon - chemistry; Carboxylates; Catalysis; Catalysts; Cationic; Cations - chemistry; Chemistry; Chemistry, Multidisciplinary; Cobalt; Cobalt - chemistry; cyanides; Cyanides - chemistry; CH activation; heterocycles; Hydrogen - chemistry; Indoles - chemistry; Nitriles; Physical Sciences; Science & Technology; Synthesis; synthetic methods; COMPLEX; ACTIVATION; DIRECT ARYLATION; cyanides; BOND FUNCTIONALIZATIONS; cobalt; ALKYNES; CARBON-HYDROGEN; ARYL BROMIDES; MILD; N,N-DIMETHYLFORMAMIDE; C-H activation; heterocycles; synthetic methods; HYDROARYLATION; CH activation

Carboxylate assistance proved to be the key for the success of efficient cobalt(III)‐catalyzed CH cyanations. Thus, an in situ generated cationic cobalt complex was identified as a versatile catalyst for the site‐selective synthesis of various aromatic and heteroaromatic nitriles with ample substra...