Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants

• Published in: Transplantation Vol. 99; no. 2; p. 288
• Main Authors: Leventhal, Joseph R, Elliott, Mary J, Yolcu, Esma S, Bozulic, Larry D, Tollerud, David J, Mathew, James M, Konieczna, Iwona, Ison, Michael G, Galvin, John, Mehta, Jayesh, Badder, Mark D, Abecassis, Michael M I, Miller, Joshua, Gallon, Lorenzo, Ildstad, Suzanne T
• Format: Journal Article
• Language: English
• Published: United States 01.02.2015
• Subjects: Adolescent; Adult; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Chicago; Communicable Diseases - immunology; Female; Graft Rejection - immunology; Graft Rejection - prevention & control; Graft Survival; Hematopoietic Stem Cell Transplantation; Histocompatibility; HLA Antigens - immunology; Humans; Immunocompromised Host; Immunologic Memory; Immunosuppressive Agents - administration & dosage; Isoantibodies - blood; Kentucky; Kidney Diseases - blood; Kidney Diseases - diagnosis; Kidney Diseases - immunology; Kidney Diseases - surgery; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Living Donors; Male; Middle Aged; Prospective Studies; Recurrence; Risk Factors; Time Factors; Transplantation Chimera; Transplantation Conditioning - methods; Transplantation Tolerance - drug effects; Treatment Outcome; Vaccination; Young Adult; Chicago; Kentucky

Nineteen subjects have more than 18 months' follow-up in a phase IIb tolerance protocol in HLA-mismatched recipients of living donor kidney plus facilitating cell enriched hematopoietic stem cell allografts (FCRx). Reduced intensity conditioning preceded a kidney allograft, followed the next da...