Proliferation of myogenic stem cells in human skeletal muscle in response to low‐load resistance training with blood flow restriction
Key points In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass. The cellular mechanisms responsible f...
Saved in:
| Published in | The Journal of physiology Vol. 590; no. 17; pp. 4351 - 4361 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.09.2012
Wiley Subscription Services, Inc Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Key points
In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass.
The cellular mechanisms responsible for the muscular adaptations induced by this training paradigm are not fully understood.
This study shows that 3 weeks of high‐frequency, low‐intensity muscle exercise with partial blood flow restriction induces increases in maximal muscle strength accompanied by highly marked gains in muscle fibre size.
Furthermore, the results indicate that these muscular adaptations rely on a considerable upregulation in myogenic satellite cells number, resulting in nuclear addition to the exercised myofibres.
The results contribute to a better understanding of the physiological mechanisms underlying the gain in muscle strength and muscle mass observed with blood flow restricted low‐intensity resistance exercise.
Low‐load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work‐matched controls (21.9 ± 3.0 years) trained without BFR (control, CON). Twenty‐three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre‐ and post‐training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35–37% (Post3) and 31–32% (Post10) (P < 0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) (P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22 (Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), (P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short‐term low‐load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. |
|---|---|
| AbstractList | Key points
In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass.
The cellular mechanisms responsible for the muscular adaptations induced by this training paradigm are not fully understood.
This study shows that 3 weeks of high‐frequency, low‐intensity muscle exercise with partial blood flow restriction induces increases in maximal muscle strength accompanied by highly marked gains in muscle fibre size.
Furthermore, the results indicate that these muscular adaptations rely on a considerable upregulation in myogenic satellite cells number, resulting in nuclear addition to the exercised myofibres.
The results contribute to a better understanding of the physiological mechanisms underlying the gain in muscle strength and muscle mass observed with blood flow restricted low‐intensity resistance exercise.
Low‐load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work‐matched controls (21.9 ± 3.0 years) trained without BFR (control, CON). Twenty‐three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre‐ and post‐training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35–37% (Post3) and 31–32% (Post10) (P < 0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) (P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22 (Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), (P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short‐term low‐load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. Low-load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9 ± 3.0 years) trained without BFR (control, CON). Twenty-three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre- and post-training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) ( P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35–37% (Post3) and 31–32% (Post10) ( P < 0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) ( P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22 (Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), ( P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short-term low-load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. Low-load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years)performed four sets of knee extensor exercise (20% 1RM) to concentric failure during bloodflow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls(21.9 ± 3.0 years) trained without BFR (control, CON). Twenty-three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre- and post-training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention(Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12)(P <0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35 – 37%(Post3) and 31 – 32% (Post10) (P <0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) (P <0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22(Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), (P<0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short-term low-load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. times In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass. Abstract Low-load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 plus or minus 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9 plus or minus 3.0 years) trained without BFR (control, CON). Twenty-three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre- and post-training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35-37% (Post3) and 31-32% (Post10) (P < 0.001). MSCs per myofibre increased with BFR training from 0.10 plus or minus 0.01 (Pre) to 0.38 plus or minus 0.02 (Mid8), 0.36 plus or minus 0.04 (Post3) and 0.25 plus or minus 0.02 (Post10) (P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 plus or minus 0.07 (Pre) to 3.30 plus or minus 0.22 (Mid8), 3.20 plus or minus 0.16 (Post3) and 3.11 plus or minus 0.11 (Post10), (P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short-term low-load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. Key points In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass. The cellular mechanisms responsible for the muscular adaptations induced by this training paradigm are not fully understood. This study shows that 3 weeks of high‐frequency, low‐intensity muscle exercise with partial blood flow restriction induces increases in maximal muscle strength accompanied by highly marked gains in muscle fibre size. Furthermore, the results indicate that these muscular adaptations rely on a considerable upregulation in myogenic satellite cells number, resulting in nuclear addition to the exercised myofibres. The results contribute to a better understanding of the physiological mechanisms underlying the gain in muscle strength and muscle mass observed with blood flow restricted low‐intensity resistance exercise. Abstract Low‐load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work‐matched controls (21.9 ± 3.0 years) trained without BFR (control, CON). Twenty‐three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre‐ and post‐training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) ( P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35–37% (Post3) and 31–32% (Post10) ( P < 0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) ( P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22 (Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), ( P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short‐term low‐load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. Key points In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has gained increasing interest, since it leads to significant gains in muscle strength and muscle mass. The cellular mechanisms responsible for the muscular adaptations induced by this training paradigm are not fully understood. This study shows that 3 weeks of high-frequency, low-intensity muscle exercise with partial blood flow restriction induces increases in maximal muscle strength accompanied by highly marked gains in muscle fibre size. Furthermore, the results indicate that these muscular adaptations rely on a considerable upregulation in myogenic satellite cells number, resulting in nuclear addition to the exercised myofibres. The results contribute to a better understanding of the physiological mechanisms underlying the gain in muscle strength and muscle mass observed with blood flow restricted low-intensity resistance exercise. Abstract Low-load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect on myogenic stem cells (MSCs) and myonuclei number remains unexplored. Ten male subjects (22.8 ± 2.3 years) performed four sets of knee extensor exercise (20% 1RM) to concentric failure during blood flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9 ± 3.0 years) trained without BFR (control, CON). Twenty-three training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre- and post-training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P < 0.001) with BFR training, while type I and II MFA increased by 38% (Mid8), 35-37% (Post3) and 31-32% (Post10) (P < 0.001). MSCs per myofibre increased with BFR training from 0.10 ± 0.01 (Pre) to 0.38 ± 0.02 (Mid8), 0.36 ± 0.04 (Post3) and 0.25 ± 0.02 (Post10) (P < 0.001). Likewise, myonuclei per myofibre increased from 2.49 ± 0.07 (Pre) to 3.30 ± 0.22 (Mid8), 3.20 ± 0.16 (Post3) and 3.11 ± 0.11 (Post10), (P < 0.01). Although MFA increased in CON at Mid8, it returned to baseline at Post3. No changes in MSC or myonuclei number were observed in CON. This study is the first to show that short-term low-load resistance exercise performed with partial blood flow restriction leads to marked proliferation of myogenic stem cells and resulting myonuclei addition in human skeletal muscle, which is accompanied by substantial myofibre hypertrophy. |
| Author | Aagaard, Per Frandsen, Ulrik Bech, Rune Dueholm Wernbom, Mathias Suetta, Charlotte Nielsen, Jakob Lindberg Hvid, Lars Grøndahl Nygaard, Tobias |
| Author_xml | – sequence: 1 givenname: Jakob Lindberg surname: Nielsen fullname: Nielsen, Jakob Lindberg – sequence: 2 givenname: Per surname: Aagaard fullname: Aagaard, Per – sequence: 3 givenname: Rune Dueholm surname: Bech fullname: Bech, Rune Dueholm – sequence: 4 givenname: Tobias surname: Nygaard fullname: Nygaard, Tobias – sequence: 5 givenname: Lars Grøndahl surname: Hvid fullname: Hvid, Lars Grøndahl – sequence: 6 givenname: Mathias surname: Wernbom fullname: Wernbom, Mathias – sequence: 7 givenname: Charlotte surname: Suetta fullname: Suetta, Charlotte – sequence: 8 givenname: Ulrik surname: Frandsen fullname: Frandsen, Ulrik |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22802591$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkrtuFDEUhi0URDaBN0DIEg3NLL6Mx-MGCUVcFYkUoba8vux68diLPZPVdnS0PCNPgkebREADlaXzf-f3OUf_GTiJKVoAnmK0xBjTl9vd5lB8CkuCMFkSyhHqH4AFbjvRcC7oCVggREhDOcOn4KyULUKYIiEegVNCekSYwAvw_Sqn4J3NavQpwuTgcEhrG72GZbQD1DaEAn2Em2lQEZYvNthRBThMRQc7C9mWXYrFwjHBkPY_v_0ISZm57Muooq5CVj76uIZ7P27gKqRkoKvozIzZ6_nnx-ChU6HYJ7fvOfj89s31xfvm8tO7DxevLxvNsOga0bdUCNt2rXOUdVphvBJ8ZTpOjEZY9R3CPTHCGUot4doYptnKcdN1xPWY0HPw6ui7m1aDNdrGOl2Qu-wHlQ8yKS__VKLfyHW6kbTllAhUDV7cGuT0daoLyMGX-Uoq2jQViXvKK4t7_m8U0WpY-dn1-V_oNk051ktIzFpGWyQYrVR7pHROpWTr7ufGSM6hkHehkHMo5DEUte3Z7zvfN92loALiCOx9sIf_MpXXH68Y6Tv6CzeJzSA |
| CODEN | JPHYA7 |
| CitedBy_id | crossref_primary_10_1016_j_redox_2023_102894 crossref_primary_10_1152_japplphysiol_00257_2019 crossref_primary_10_1080_17461391_2023_2201813 crossref_primary_10_1093_gerona_glu084 crossref_primary_10_1016_j_ptsp_2021_01_014 crossref_primary_10_1080_03009742_2017_1423109 crossref_primary_10_15758_ajk_2024_26_2_65 crossref_primary_10_3389_fphys_2022_838004 crossref_primary_10_3389_fphys_2020_00556 crossref_primary_10_1016_j_pmr_2016_07_002 crossref_primary_10_3390_ijms19113649 crossref_primary_10_1016_j_asmr_2020_09_009 crossref_primary_10_2106_JBJS_RVW_22_00062 crossref_primary_10_1249_MSS_0000000000002824 crossref_primary_10_1152_japplphysiol_01055_2014 crossref_primary_10_1186_s12891_023_06483_x crossref_primary_10_3389_fphys_2018_01376 crossref_primary_10_3390_biology10101056 crossref_primary_10_5812_asjsm_38458 crossref_primary_10_1152_japplphysiol_00529_2022 crossref_primary_10_1007_s00421_014_2864_3 crossref_primary_10_1007_s00421_020_04337_1 crossref_primary_10_1007_s40279_014_0288_1 crossref_primary_10_1139_apnm_2016_0224 crossref_primary_10_1016_j_nmd_2022_04_006 crossref_primary_10_1113_JP273907 crossref_primary_10_1152_ajpregu_00061_2020 crossref_primary_10_1249_MSS_0000000000001208 crossref_primary_10_1111_sms_13952 crossref_primary_10_1007_s00421_017_3690_1 crossref_primary_10_1016_j_tcm_2014_12_014 crossref_primary_10_1152_japplphysiol_00789_2022 crossref_primary_10_3389_fspor_2021_798902 crossref_primary_10_1016_j_asmr_2021_09_025 crossref_primary_10_1113_EP089280 crossref_primary_10_1016_j_tem_2020_11_010 crossref_primary_10_1152_japplphysiol_00754_2019 crossref_primary_10_1249_MSS_0000000000001071 crossref_primary_10_4081_ejtm_2020_9311 crossref_primary_10_1152_japplphysiol_00501_2016 crossref_primary_10_1519_JSC_0000000000004034 crossref_primary_10_3389_fphys_2015_00283 crossref_primary_10_1080_17461391_2022_2039781 crossref_primary_10_1177_0363546520901539 crossref_primary_10_26862_jkpts_2022_06_29_2_48 crossref_primary_10_1002_mus_25488 crossref_primary_10_3389_fphys_2017_00190 crossref_primary_10_1016_j_arthro_2018_06_022 crossref_primary_10_1111_sms_12210 crossref_primary_10_1371_journal_pone_0283309 crossref_primary_10_3389_fphys_2020_00817 crossref_primary_10_1111_sms_14079 crossref_primary_10_1007_s00421_017_3622_0 crossref_primary_10_1007_s00421_017_3770_2 crossref_primary_10_1152_japplphysiol_00602_2019 crossref_primary_10_1007_s00421_020_04378_6 crossref_primary_10_1152_japplphysiol_01012_2020 crossref_primary_10_1007_s40279_015_0407_7 crossref_primary_10_1007_s40279_014_0264_9 crossref_primary_10_1152_ajpregu_00497_2014 crossref_primary_10_1186_s13063_022_06017_1 crossref_primary_10_1007_s40279_018_0994_1 crossref_primary_10_14814_phy2_15480 crossref_primary_10_1152_ajpheart_00027_2018 crossref_primary_10_1519_JSC_0000000000002384 crossref_primary_10_1113_jphysiol_2012_242859 crossref_primary_10_1371_journal_pone_0148236 crossref_primary_10_1152_japplphysiol_00464_2021 crossref_primary_10_1249_MSS_0000000000002156 crossref_primary_10_1519_JSC_0000000000004553 crossref_primary_10_1097_JSM_0000000000000377 crossref_primary_10_1007_s00113_020_00779_6 crossref_primary_10_1152_japplphysiol_00171_2020 crossref_primary_10_1113_JP275149 crossref_primary_10_1519_JSC_0000000000003628 crossref_primary_10_1136_bmjopen_2019_034376 crossref_primary_10_26603_001c_68143 crossref_primary_10_1155_2024_4413113 crossref_primary_10_1249_JES_0000000000000234 crossref_primary_10_1007_s12178_020_09610_6 crossref_primary_10_3357_AMHP_5855_2021 crossref_primary_10_1249_JES_0000000000000231 crossref_primary_10_18632_oncotarget_9564 crossref_primary_10_1152_ajpheart_00208_2015 crossref_primary_10_1152_japplphysiol_00917_2018 crossref_primary_10_1186_s13075_019_2036_2 crossref_primary_10_3389_fphys_2020_00243 crossref_primary_10_2478_hukin_2022_0095 crossref_primary_10_5812_jamm_106779 crossref_primary_10_1053_j_jfas_2017_11_008 crossref_primary_10_1556_APhysiol_101_2014_2_4 crossref_primary_10_3390_jfmk8020051 crossref_primary_10_1152_japplphysiol_00235_2022 crossref_primary_10_1016_j_mehy_2014_02_023 crossref_primary_10_1097_BTO_0000000000000265 crossref_primary_10_1111_apha_13302 crossref_primary_10_3390_rheumato3010003 crossref_primary_10_1152_japplphysiol_00397_2018 crossref_primary_10_1016_j_arthro_2022_06_027 crossref_primary_10_1519_JSC_0000000000001218 crossref_primary_10_1007_s40279_014_0177_7 crossref_primary_10_1177_2151458515583088 crossref_primary_10_1152_japplphysiol_00704_2022 crossref_primary_10_1007_s40520_014_0208_0 crossref_primary_10_1249_MSS_0000000000001775 crossref_primary_10_1016_j_jsams_2015_04_014 crossref_primary_10_1111_sms_12396 crossref_primary_10_1249_MSS_0000000000000722 crossref_primary_10_1111_cpf_12509 crossref_primary_10_3390_ijms22052741 crossref_primary_10_1038_s41598_020_62456_3 crossref_primary_10_1134_S0362119713050162 crossref_primary_10_1097_BTO_0000000000000252 crossref_primary_10_1007_s00421_015_3304_8 crossref_primary_10_1016_j_arthro_2018_05_038 crossref_primary_10_1016_j_eats_2018_06_010 crossref_primary_10_1111_sms_13516 crossref_primary_10_1111_sms_13632 crossref_primary_10_1007_s00421_021_04862_7 crossref_primary_10_1007_s40279_017_0795_y crossref_primary_10_1371_journal_pone_0158860 crossref_primary_10_1519_JSC_0b013e3182874721 crossref_primary_10_3389_fphys_2017_00383 crossref_primary_10_1016_j_asmr_2022_04_002 crossref_primary_10_52082_jssm_2024_326 crossref_primary_10_1007_s12603_013_0362_7 crossref_primary_10_1016_j_jsams_2015_09_005 crossref_primary_10_1093_ptj_pzz062 crossref_primary_10_1177_26350254231202532 crossref_primary_10_1152_japplphysiol_00506_2019 crossref_primary_10_1177_0031512518776847 crossref_primary_10_1111_cpf_12259 crossref_primary_10_1152_ajpregu_00038_2021 crossref_primary_10_1519_JSC_0000000000004079 crossref_primary_10_3390_sports12060171 crossref_primary_10_1007_s00421_019_04217_3 crossref_primary_10_1177_03635465211027296 crossref_primary_10_3390_biomedicines11061601 crossref_primary_10_1177_1941738118821929 crossref_primary_10_17338_trainology_1_2_36 crossref_primary_10_1007_s40279_023_01900_6 crossref_primary_10_1519_JSC_0000000000001478 crossref_primary_10_1371_journal_pone_0279811 crossref_primary_10_1210_clinem_dgad432 crossref_primary_10_2478_hukin_2018_0101 crossref_primary_10_1111_sms_12259 crossref_primary_10_1152_japplphysiol_00115_2020 crossref_primary_10_3389_fphys_2019_00649 crossref_primary_10_1002_jcsm_12397 crossref_primary_10_7600_jpfsm_4_43 crossref_primary_10_1016_j_jse_2020_02_003 crossref_primary_10_1152_ajpendo_00600_2013 crossref_primary_10_17338_trainology_3_1_1 crossref_primary_10_18857_jkpt_2017_29_2_69 crossref_primary_10_1186_s12891_023_06693_3 crossref_primary_10_1055_a_2152_0015 crossref_primary_10_1152_japplphysiol_00015_2020 crossref_primary_10_1152_japplphysiol_00261_2014 crossref_primary_10_1371_journal_pone_0295666 crossref_primary_10_3389_fphys_2019_00533 crossref_primary_10_1111_apha_14030 crossref_primary_10_1177_23259671231209694 crossref_primary_10_3390_jcm11164881 crossref_primary_10_1519_JSC_0000000000000680 crossref_primary_10_4085_1062_6050_463_16 crossref_primary_10_1111_apha_12243 crossref_primary_10_1519_JSC_0000000000003148 crossref_primary_10_1152_ajpregu_00243_2019 crossref_primary_10_1186_s40634_022_00533_4 crossref_primary_10_1177_15563316241245700 crossref_primary_10_1519_SSC_0000000000000553 crossref_primary_10_14814_phy2_12449 crossref_primary_10_1111_sms_12087 crossref_primary_10_1177_23259671231213034 crossref_primary_10_1007_s00421_013_2733_5 crossref_primary_10_1519_SSC_0000000000000556 |
| Cites_doi | 10.1152/ajpcell.00513.2005 10.1113/jphysiol.2006.107359 10.1249/MSS.0b013e318160ff84 10.1016/j.freeradbiomed.2004.06.026 10.1007/s004180050012 10.1111/j.1600-0838.2009.01044.x 10.1007/s004210050663 10.1016/0735-1097(96)00218-5 10.1111/j.1600-0838.2010.01178.x 10.1113/jphysiol.2004.065904 10.1002/mus.21369 10.1152/japplphysiol.00195.2007 10.1123/jab.22.2.112 10.1111/j.1748-1716.2010.02172.x 10.1073/pnas.0913935107 10.1161/01.RES.57.4.599 10.1152/japplphysiol.90538.2008 10.1002/mus.20461 10.1152/japplphysiol.01267.2005 10.1091/mbc.10.4.1247 10.1371/journal.pone.0012033 10.1083/jcb.9.2.493 10.1152/japplphysiol.01266.2009 10.1139/Y10-012 10.1111/j.1469-7793.2001.t01-1-00613.x 10.1113/jphysiol.2004.061846 10.1249/MSS.0b013e318233b4bc 10.1152/japplphysiol.00307.2012 10.1152/japplphysiol.01215.2007 10.1007/s00421-001-0561-5 |
| ContentType | Journal Article |
| Copyright | 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society 2012 |
| Copyright_xml | – notice: 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society – notice: 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society 2012 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7QR 7TK 7TS 8FD FR3 P64 7X8 5PM |
| DOI | 10.1113/jphysiol.2012.237008 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Physical Education Index Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Technology Research Database Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Physical Education Index Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Physical Education Index CrossRef Technology Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1469-7793 |
| EndPage | 4361 |
| ExternalDocumentID | 3374396271 10_1113_jphysiol_2012_237008 22802591 TJP5286 |
| Genre | rapidPublication Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -DZ -~X .3N .55 .GA .GJ .Y3 05W 0R~ 0YM 10A 123 18M 1OB 1OC 24P 29L 2WC 31~ 33P 36B 3EH 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAFWJ AAHHS AANLZ AAONW AASGY AAXRX AAYJJ AAZKR ABCQN ABCUV ABEML ABITZ ABIVO ABJNI ABOCM ABPPZ ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFO ACGFS ACGOF ACIWK ACMXC ACNCT ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AI. AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C1A C45 CAG CHEAL COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM E3Z EBS EJD EMOBN EX3 F00 F01 F04 F5P FA8 FIJ FUBAC G-S G.N GODZA GX1 H.X H13 HF~ HGLYW HZI HZ~ H~9 IHE IPNFZ IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MVM MXFUL MXMAN MXSTM N04 N05 N9A NEJ NF~ O66 O9- OHT OIG OK1 OVD P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 R.K RIG ROL RPM RX1 SAMSI SUPJJ TEORI TLM TN5 TR2 UB1 UKR UPT V8K VH1 W8F W8V W99 WBKPD WH7 WHG WIH WIJ WIK WIN WNSPC WOHZO WOQ WOW WQJ WRC WXI WXSBR WYISQ X7M XG1 XOL YBU YHG YKV YQT YSK YXB YYP YZZ ZGI ZXP ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7QR 7TK 7TS 8FD FR3 P64 7X8 5PM |
| ID | FETCH-LOGICAL-c5196-984399e464ff356ca11b97bd672dc01a860182d9fd33e27cdd5c5bf7d662f8123 |
| IEDL.DBID | RPM |
| ISSN | 0022-3751 |
| IngestDate | Tue Sep 17 20:58:20 EDT 2024 Sat Aug 17 02:34:52 EDT 2024 Fri Aug 16 12:05:19 EDT 2024 Fri Sep 13 05:59:49 EDT 2024 Fri Aug 23 00:48:44 EDT 2024 Tue Aug 27 13:46:10 EDT 2024 Sat Aug 24 00:46:26 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 17 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5196-984399e464ff356ca11b97bd672dc01a860182d9fd33e27cdd5c5bf7d662f8123 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473290 |
| PMID | 22802591 |
| PQID | 1545340953 |
| PQPubID | 1086388 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3473290 proquest_miscellaneous_1837347187 proquest_miscellaneous_1039038370 proquest_journals_1545340953 crossref_primary_10_1113_jphysiol_2012_237008 pubmed_primary_22802591 wiley_primary_10_1113_jphysiol_2012_237008_TJP5286 |
| PublicationCentury | 2000 |
| PublicationDate | September 2012 |
| PublicationDateYYYYMMDD | 2012-09-01 |
| PublicationDate_xml | – month: 09 year: 2012 text: September 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England – name: London |
| PublicationTitle | The Journal of physiology |
| PublicationTitleAlternate | J Physiol |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc Blackwell Science Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc – name: Blackwell Science Inc |
| References | 2007; 103 2009; 40 2010; 107 2000; 113 2010; 108 2006; 33 2008; 105 2008; 104 2006; 290 2006; 573 2010; 88 2010; 21 2011; 201 1996; 28 2012; 113 2002; 86 2006; 22 2004; 37 1999; 10 2011; 21 2000; 82 1961; 9 2008; 40 2010; 5 2004; 558 2012; 44 2006; 100 1985; 57 2001; 534 28949007 - J Physiol. 2017 Nov 15;595(22):6817-6818 23118067 - J Physiol. 2012 Nov 1;590(21):5271 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – volume: 57 start-page: 599 year: 1985 end-page: 609 article-title: The role of oxygen‐derived free radicals in ischemia‐induced increases in canine skeletal muscle vascular permeability publication-title: Circ Res – volume: 22 start-page: 112 year: 2006 end-page: 119 article-title: Effects of low‐load resistance training with vascular occlusion on the mechanical properties of muscle and tendon publication-title: J Appl Biomech – volume: 103 start-page: 903 year: 2007 end-page: 910 article-title: Blood flow restriction during low‐intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis publication-title: J Appl Physiol – volume: 113 start-page: 71 year: 2012 end-page: 77 article-title: Resistance exercise load does not determine training‐mediated hypertrophic gains in young men publication-title: J Appl Physiol – volume: 100 start-page: 1460 year: 2006 end-page: 1466 article-title: Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu‐walk training publication-title: J Appl Physiol – volume: 44 start-page: 406 year: 2012 end-page: 412 article-title: Strength training with blood flow restriction diminishes myostatin gene expression publication-title: Med Sci Sports Exerc – volume: 558 start-page: 1005 year: 2004 end-page: 1012 article-title: The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles publication-title: J Physiol – volume: 88 start-page: 388 year: 2010 end-page: 397 article-title: Ischemia‐reperfusion‐induced changes in sarcolemmal Na /K ‐ATPase are due to the activation of calpain in the heart publication-title: Can J Physiol Pharmacol – volume: 290 start-page: C1487 year: 2006 end-page: 1494 article-title: Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor publication-title: Am J Physiol Cell Physiol – volume: 40 start-page: 691 year: 2008 end-page: 698 article-title: Human muscle gene expression following resistance exercise and blood flow restriction publication-title: Med Sci Sports Exerc – volume: 10 start-page: 1247 year: 1999 end-page: 1257 article-title: Temporary disruption of the plasma membrane is required for c‐fos expression in response to mechanical stress publication-title: Mol Biol Cell – volume: 108 start-page: 1199 year: 2010 end-page: 1209 article-title: Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men publication-title: J Appl Physiol – volume: 104 start-page: 1736 year: 2008 end-page: 1742 article-title: Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell‐mediated myonuclear addition: a cluster analysis publication-title: J Appl Physiol – volume: 28 start-page: 591 year: 1996 end-page: 596 article-title: Endothelium‐derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans publication-title: J Am Coll Cardiol – volume: 5 start-page: e12033 year: 2010 article-title: Low‐load high volume resistance exercise stimulates muscle protein synthesis more than high‐load low volume resistance exercise in young men publication-title: PLoS One – volume: 534 start-page: 613 year: 2001 end-page: 623 article-title: A mechanism for increased contractile strength of human pennate muscle in response to strength training: changes in muscle architecture publication-title: J Physiol – volume: 21 start-page: 773 year: 2010 end-page: 782 article-title: Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity publication-title: Scand J Med Sci Sports – volume: 105 start-page: 1454 year: 2008 end-page: 1461 article-title: Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity publication-title: J Appl Physiol – volume: 40 start-page: 455 year: 2009 end-page: 465 article-title: Assessment of satellite cell number and activity status in human skeletal muscle biopsies publication-title: Muscle Nerve – volume: 113 start-page: 99 year: 2000 end-page: 103 article-title: Concomitant increases in myonuclear and satellite cell content in female trapezius muscle following strength training publication-title: Histochem Cell Biol – volume: 86 start-page: 308 year: 2002 end-page: 314 article-title: Effects of resistance exercise combined with vascular occlusion on muscle function in athletes publication-title: Eur J Appl Physiol – volume: 21 start-page: 215 year: 2011 end-page: 223 article-title: Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining publication-title: Scand J Med Sci Sports – volume: 37 start-page: 1064 year: 2004 end-page: 1072 article-title: Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells publication-title: Free Radic Biol Med – volume: 82 start-page: 137 year: 2000 end-page: 141 article-title: Effects of dynamic ischaemic training on human skeletal muscle dimensions publication-title: Eur J Appl Physiol – volume: 573 start-page: 525 year: 2006 end-page: 534 article-title: Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training publication-title: J Physiol – volume: 558 start-page: 333 year: 2004 end-page: 340 article-title: Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise publication-title: J Physiol – volume: 9 start-page: 493 year: 1961 end-page: 495 article-title: Satellite cell of skeletal muscle fibers publication-title: J Biophys Biochem Cytol – volume: 107 start-page: 15111 year: 2010 end-page: 15116 article-title: Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining publication-title: Proc Natl Acad Sci U S A – volume: 33 start-page: 242 year: 2006 end-page: 253 article-title: Satellite cell numbers in young and older men 24 hours after eccentric exercise publication-title: Muscle Nerve – volume: 201 start-page: 255 year: 2011 end-page: 263 article-title: Myogenic and proteolytic mRNA expression following blood flow restricted exercise publication-title: Acta Physiol (Oxf) – ident: e_1_2_6_31_1 doi: 10.1152/ajpcell.00513.2005 – ident: e_1_2_6_26_1 doi: 10.1113/jphysiol.2006.107359 – ident: e_1_2_6_9_1 doi: 10.1249/MSS.0b013e318160ff84 – ident: e_1_2_6_27_1 doi: 10.1016/j.freeradbiomed.2004.06.026 – ident: e_1_2_6_16_1 doi: 10.1007/s004180050012 – ident: e_1_2_6_14_1 doi: 10.1111/j.1600-0838.2009.01044.x – ident: e_1_2_6_25_1 doi: 10.1007/s004210050663 – ident: e_1_2_6_4_1 doi: 10.1016/0735-1097(96)00218-5 – ident: e_1_2_6_20_1 doi: 10.1111/j.1600-0838.2010.01178.x – ident: e_1_2_6_15_1 doi: 10.1113/jphysiol.2004.065904 – ident: e_1_2_6_21_1 doi: 10.1002/mus.21369 – ident: e_1_2_6_11_1 doi: 10.1152/japplphysiol.00195.2007 – ident: e_1_2_6_18_1 doi: 10.1123/jab.22.2.112 – ident: e_1_2_6_22_1 doi: 10.1111/j.1748-1716.2010.02172.x – ident: e_1_2_6_5_1 doi: 10.1073/pnas.0913935107 – ident: e_1_2_6_17_1 doi: 10.1161/01.RES.57.4.599 – ident: e_1_2_6_13_1 doi: 10.1152/japplphysiol.90538.2008 – ident: e_1_2_6_8_1 doi: 10.1002/mus.20461 – ident: e_1_2_6_3_1 doi: 10.1152/japplphysiol.01267.2005 – ident: e_1_2_6_12_1 doi: 10.1091/mbc.10.4.1247 – ident: e_1_2_6_6_1 doi: 10.1371/journal.pone.0012033 – ident: e_1_2_6_23_1 doi: 10.1083/jcb.9.2.493 – ident: e_1_2_6_10_1 doi: 10.1152/japplphysiol.01266.2009 – ident: e_1_2_6_29_1 doi: 10.1139/Y10-012 – ident: e_1_2_6_2_1 doi: 10.1111/j.1469-7793.2001.t01-1-00613.x – ident: e_1_2_6_7_1 doi: 10.1113/jphysiol.2004.061846 – ident: e_1_2_6_19_1 doi: 10.1249/MSS.0b013e318233b4bc – ident: e_1_2_6_24_1 doi: 10.1152/japplphysiol.00307.2012 – ident: e_1_2_6_28_1 doi: 10.1152/japplphysiol.01215.2007 – ident: e_1_2_6_30_1 doi: 10.1007/s00421-001-0561-5 |
| SSID | ssj0013099 |
| Score | 2.5188313 |
| Snippet | Key points
In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb... Low-load resistance training with blood flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however, the effect... Key points In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb... times In the last decade muscle training performed using a combination of low external loads and partial restriction of blood flow to the exercising limb has... |
| SourceID | pubmedcentral proquest crossref pubmed wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 4351 |
| SubjectTerms | Adult Stem Cells - cytology Adult Stem Cells - physiology Cell Proliferation Exercise - physiology Humans Hypertrophy - pathology Male Muscle Strength - physiology Muscle, Skeletal - blood supply Muscle, Skeletal - pathology Muscle, Skeletal - physiology Myoblasts, Skeletal - cytology Myoblasts, Skeletal - physiology Regional Blood Flow - physiology Resistance Training Satellite Cells, Skeletal Muscle - cytology Satellite Cells, Skeletal Muscle - physiology Skeletal Muscle and Exercise Young Adult |
| SummonAdditionalLinks | – databaseName: Wiley Online Library - Core collection (SURFmarket) dbid: DR2 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaqnrjwKo9AQUZC3LIkduzExwqxqiqBVqiVeouc2C5Lu3HV3RVaTty48hv5JczYSWApQgiu8cSJnZn4-_z4hpDnrgEQIMOxD1GlhdFtqo1VqbQaBeKcFEFn9s1beXhSHJ2K0x0yHc7CRH2IccINIyP8rzHAddNnIclRbOBDoP4elw9yNmG8jGd-UVMPsdE79mMxIVNqFA0vRd6foINqXv6uku0R6hrsvL578mdUG4al6S1yNjQo7kY5n6xXzaT99IvW4_-3-Da52SNXehBd7Q7Zsd1dsnfQAWtfbOgLOou3-bPNHvkyw2RAzkb3ot7RxcaDq85bisLRFJcLlnTe0ZAikC7PYfADFkAX6yXUjQVXce-upStPL_zHb5-_Xnht8DICXvBUOiS3oDiVTMMGfOrAFG0w7QA--R45mb4-fnWY9ikf0hagpExVhfzIFrJwjgvZ6jxvVNkYWTLTZrmugD9WzChnOLesbI0RrWhcaaRkDrAKv092O9_Zh4QKpy2wVWGAAhZa20ZL7axQqrFAaplOSDp85voyKnvUkRHxeujpGnu6jj2dkP3BF-o-zpc1AlBeoGZfQp6NxRCh2I-6s34NNhlXGU4EZH-wgWKOOKFMyIPoXuNLoWARkNQ8IeWW440GqBC-XdLN3welcKiSMwXPZcGv_qqd9fHRTLBKPvqXmx6TG3g1bsLbJ7urq7V9Aqht1TwNMfkd6OhCaw priority: 102 providerName: Wiley-Blackwell |
| Title | Proliferation of myogenic stem cells in human skeletal muscle in response to low‐load resistance training with blood flow restriction |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1113%2Fjphysiol.2012.237008 https://www.ncbi.nlm.nih.gov/pubmed/22802591 https://www.proquest.com/docview/1545340953/abstract/ https://search.proquest.com/docview/1039038370 https://search.proquest.com/docview/1837347187 https://pubmed.ncbi.nlm.nih.gov/PMC3473290 |
| Volume | 590 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9swEBZtn_YytnU_vHVFg7E3J7ZkSdZjKetKoSOMFvJmZEvassVWaRJG_oD937uT7bBQGGMveYgOW_aduO-TT98R8t7XAAJkPPYhyrSwpkmNdTqVzqBAnJci6sxef5aXt8XVXMwPiBjPwsSi_aZeTLplO-kW32Jt5V3bTMc6sens-pwXijOdTQ_JoeJ8pOjjp4NM651EuBL5cF4uz_n0e9wtCPjFIWcTxhUkQFQDZiVkfp3vp6YHePNh2eSfcDbmo4sn5PEAJOlZP-Gn5MB1z8jxWQckut3SD3TWTyJ83R6TXzPszeNd720aPG23ASJn0VDUcaa4e7-ii47Gjn109QNyEYBy2m5WcG0cuO9LaR1dB7oMP9NlMBb_RPQJYUPHThMU93VprIanHgzRBnsA4H2fk9uLjzfnl-nQfyFtANfJVJdIVlwhC--5kI3J81qr2krFbJPlpgQyVzKrveXcMdVYKxpRe2WlZB6AA39BjrrQuVeECm8cUEdhgY8VxrjaSOOd0Lp2wDCZSUg6vvrqrpfZqHp6wqvRaxV6req9lpCT0T_VsOhWFaJBXqCAXkLe7YZhueBbNJ0LG7DJuM6QlWd_sYFhjklbJeRl7_LdpMZYSYjaC4adAcp1749AFEfZ7iFqE8Ji2PzTc1Y3VzPBSvn6v2_3hjzC6_VlcSfkaH2_cW8BR63rU2AQXxj8fprnp3EN_QbrICEU |
| link.rule.ids | 230,315,733,786,790,891,1382,27957,27958,46329,46753,53827,53829 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLamcYALv8aPwAAjIW4pjR078XFCjDK2qUKdtFvkxPZWtiZobYXKiRtX_kb-Et6zk0AZQghxrV-c2n2v_j77-XuEPHMlgADpr32IPE6NrmJtrIql1SgQ56TwOrMHh3J0lO4di-MN8rq7CxP0IfoNN4wM_3-NAY4b0m2Uo9rAe8_9Gzw_SNiA8cxf-r0CkS88t3rHfhwnDJXqZcMzkbR36KCfF7_rZX2NugQ8L-dP_oxr_cK0e4OcdkMK-Shng-WiHFSfflF7_A9jvkmut-CV7gRvu0U2bH2bbO3UQNxnK_qcjsNjzclqi3wZYz0gZ4OH0cbR2aoBb51WFLWjKZ4YzOm0pr5KIJ2fwfoHRIDOlnPoGxsuQvqupYuGnjcfv33-et5ogx8j5gVnpV19C4q7ydTn4FMHpmiDlQfwzXfI0e6ryctR3FZ9iCtAkzJWOVIkm8rUOS5kpZOkVFlpZMZMNUx0DhQyZ0Y5w7llWWWMqETpMiMlcwBX-F2yWTe1vU-ocNoCYRUGWGCqtS211M4KpUoLvJbpiMTd71x8COIeRSBFvOhmusCZLsJMR2S7c4aiDfV5gRiUpyjbF5GnfTMEKc6jrm2zBJshV0PcCxj-wQaaOUKFLCL3gn_1Xwo1i4CnJhHJ1jyvN0CR8PWWenrqxcKhS84UvJd5x_qrcRaTvbFguXzwLw89IVdHk4P9Yv_N4duH5BpahJy8bbK5uFjaRwDiFuVjH6DfAep1Ro0 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Pb9MwFLamISEu_BqwwAZGQtxSEjt2kuPEqMaAqUKbtFvkxPbWbU2mtRXqTrtx5W_kL9l7dhIoQwjBtX5xave9-vvs5-8R8sqWAAKku_YhsjDRqgqVNnkojUKBOCuF05n9tCd3DpLdQ3G4QobdXRivD9FvuGFkuP9rDPBzbdsgR7GBE0f9Gzw-iNmA8dTd-b2VSM7Qu7c_sx-nCVGe96rhqYjbK3TQz5vf9bK8RN3AnTfTJ3-GtW5dGt4jR92IfDrK6WA-KwfV5S9ij_8_5Pvkbgtd6Zb3tQdkxdQPydpWDbR9sqCv6cg_1hwt1sjXEVYDssb7F20snSwa8NVxRVE5muJ5wZSOa-pqBNLpKax-QAPoZD6FvrHhwifvGjpr6Fnz5fvVt7NGafwYES-4Ku2qW1DcS6YuA59aMEUbrDuAb35EDobv9t_uhG3Nh7ACLCnDPEOCZBKZWMuFrFQcl3laapkyXUWxyoBAZkznVnNuWFppLSpR2lRLySyAFf6YrNZNbdYJFVYZoKtCAwdMlDKlksoakeelAVbLVEDC7mcuzr20R-EpES-6mS5wpgs_0wHZ6HyhaAN9WiAC5QmK9gXkZd8MIYrzqGrTzMEm4nmEOwHRH2ygmSNQSAPyxLtX_6VQsQhYahyQdMnxegOUCF9uqcfHTiocuoRwgPcy51d_Nc5if3ckWCaf_stDL8jt0faw-Ph-78MzcgcNfELeBlmdXczNJiC4Wfnchec182lFPA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Proliferation+of+myogenic+stem+cells+in+human+skeletal+muscle+in+response+to+low-load+resistance+training+with+blood+flow+restriction&rft.jtitle=The+Journal+of+physiology&rft.au=Nielsen%2C+Jakob+Lindberg&rft.au=Aagaard%2C+Per&rft.au=Bech%2C+Rune+Dueholm&rft.au=Nygaard%2C+Tobias&rft.date=2012-09-01&rft.eissn=1469-7793&rft.volume=590&rft.issue=17&rft.spage=4351&rft.epage=4361&rft_id=info:doi/10.1113%2Fjphysiol.2012.237008&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3751&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3751&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3751&client=summon |