Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol

• Published in: TheScientificWorld Vol. 2016; no. 2016; pp. 1 - 4
• Main Authors: Almeida, Jackson Roberto Guedes da Silva, Carvalho, Ferdinando Oliveira, Rolim-Neto, Pedro José, Rolim, Larissa Araújo, Damasceno, Camila Mahara Dias, Reis, Silvio Alan Gonçalves Bomfim, Dantas, Milla Gabriela Belarmino, Quintans-Júnior, Lucindo José
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2016; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analgesics; Animals; Bioavailability; Bornanes - chemistry; Centrifugation; Chemical properties; Chemistry, Pharmaceutical; Colloids in medicine; Conductivity; Drug dosages; Drug Stability; Essential oils; Freezing; Gels; Herbal medicine; Hydrogen-Ion Concentration; Medicinal plants; Mice; Monoterpenes - chemistry; Nonsteroidal anti-inflammatory drugs; Production processes; Skin; Skin diseases; Software; Terpenoids; Viscosity; Brazil
• ISSN: 2356-6140; 1537-744X; 1537-744X
• DOI: 10.1155/2016/7394685

Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.