Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels

• Published in: The Journal of physiology Vol. 591; no. 8; pp. 2139 - 2156
• Main Authors: Scallan, Joshua P., Davis, Michael J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2013; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Acetylcholine; Animals; Cardiovascular; Enzyme Inhibitors - pharmacology; Hypotheses; Lymphatic Vessels - physiology; Male; Metastasis; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester - pharmacology; Nitric oxide; Nitric Oxide - physiology; Nitric Oxide Synthase Type II - deficiency; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type III - antagonists & inhibitors; Nitric Oxide Synthase Type III - deficiency; Nitric Oxide Synthase Type III - genetics; Rodents

Key points •  Stimulation of nitric oxide (NO) production by lymphatic endothelium was originally thought to inhibit lymphatic contractile function. •  However, recent studies have suggested that basal NO paradoxically increases the strength of contractions as a consequence of decreasing contraction...