Expression of Phosphodiesterase 4B cAMP-Specific Gene in Subjects With Cryptorchidism and Down's Syndrome

• Published in: Journal of clinical laboratory analysis Vol. 30; no. 3; pp. 196 - 199
• Main Authors: Salemi, Michele, Condorelli, Rosita A., La Vignera, Sandro, Castiglione, Roberto, Salluzzo, Maria Grazia, Bonaccorso, Carmela M., Vinci, Mirella, Bosco, Paolo, Romano, Carmelo, Campagna, Cristina, Romano, Corrado, Calogero, Aldo E.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2016; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adult; Birth defects; Case-Control Studies; cryptorchidism; Cryptorchidism - complications; Cryptorchidism - enzymology; Cryptorchidism - genetics; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics; Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism; Down syndrome; Down Syndrome - complications; Down Syndrome - enzymology; Down Syndrome - genetics; Down's syndrome; Enzymes; Gene expression; Humans; Male; mRNA expression; PDE4B gene; qRT-PCR; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Down's syndrome; cryptorchidism; qRT-PCR; PDE4B gene; mRNA expression

Cryptorchidism represents a risk factor for infertility and germ cell testicular neoplasia. An increased rate of cryptorchidism has been reported in subjects with Down's syndrome. Cyclic nucleotide phosphodiesterases (PDEs) are important messengers that regulate and mediate a number of cellular...