Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid

• Published in: British journal of clinical pharmacology Vol. 69; no. 2; pp. 167 - 178
• Main Authors: Landersdorfer, Cornelia B., Kirkpatrick, Carl M. J., Kinzig, Martina, Bulitta, Jürgen B., Holzgrabe, Ulrike, Jaehde, Ulrich, Reiter, Andreas, Naber, Kurt G., Rodamer, Michael, Sörgel, Fritz
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2010; Blackwell; Blackwell Science Inc
• Subjects: Adjuvants, Pharmaceutic - administration & dosage; Adjuvants, Pharmaceutic - metabolism; Adjuvants, Pharmaceutic - pharmacokinetics; Administration, Oral; Analysis of Variance; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - metabolism; Anti-Infective Agents - pharmacokinetics; Biological and medical sciences; ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - metabolism; Ciprofloxacin - pharmacokinetics; competitive inhibition; Cross-Over Studies; Drug Interactions; Female; Humans; Injections, Intravenous; Kidney Function Tests; Kidney Tubules - metabolism; Male; Medical sciences; Metabolic Clearance Rate - drug effects; metabolite formation; modelling of pharmacokinetic interaction; Models, Biological; Pharmacokinetics; Pharmacology. Drug treatments; probenecid; Probenecid - administration & dosage; Probenecid - metabolism; Probenecid - pharmacokinetics; Statistics as Topic; Metabolite; Secretion; Interaction; Competitive inhibition; modelling of pharmacokinetic interaction; Uricosuric agent; Kidney; Fluoroquinolone derivatives; Renal tubule; metabolite formation; Urinary system; Sulfonamides; Antibacterial agent; Ciprofloxacin; Pharmacokinetics; Quinolone derivatives; Probenecid

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Probenecid inhibits the active transport of both anionic and cationic drug molecules at various sites in the body. • Probenecid has been reported to decrease the elimination of several quinolones. • We are not aware of any reports where a mechanism‐based mo...