Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury

• Published in: Hepatology (Baltimore, Md.) Vol. 55; no. 4; pp. 1204 - 1214
• Main Authors: Dibra, Denada, Cutrera, Jeffry, Xia, Xueqing, Kallakury, Bhaskar, Mishra, Lopa, Li, Shulin
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2012; Wiley; Wolters Kluwer Health, Inc
• Subjects: Animals; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chemical and Drug Induced Liver Injury - prevention & control; Chemical and Drug Induced Liver Injury - therapy; Concanavalin A - adverse effects; Cytokines; Cytokines - adverse effects; Disease Models, Animal; Gastroenterology. Liver. Pancreas. Abdomen; Genetic Therapy; Hepatology; Humans; In Vitro Techniques; Inflammation; Interferon-gamma - adverse effects; Interferon-gamma - metabolism; Interleukin-12 - adverse effects; Interleukin-12 - genetics; Interleukin-12 - metabolism; Interleukins - genetics; Interleukins - metabolism; Liver; Liver - metabolism; Liver - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Minor Histocompatibility Antigens; Pharmacology. Drug treatments; Receptors, Cytokine - deficiency; Receptors, Cytokine - genetics; Receptors, Interleukin; STAT1 Transcription Factor - deficiency; STAT1 Transcription Factor - genetics; Prevention; Treatment; Liver; Interleukin; Antiinflammatory agent; Cytokine; Gastroenterology

The liver is the major metabolic organ and is subjected to constant attacks from chronic viral infection, uptake of therapeutic drugs, life behavior (alcoholic), and environmental contaminants, all of which result in chronic inflammation, fibrosis, and, ultimately, cancer. Therefore, there is an urg...