The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses - Ko, Chun‐Jung; Zhang, Lingyun; Jie, Zuliang; Zhu, Lele; Zhou, Xiaofei; Xie, Xiaoping; Gao, Tianxiao; Yang, Jin‐Young; Cheng, Xuhong; Sun, Shao‐Cong (The EMBO journal, 2021)
Keywords: Ablation; Animals; Antitumor activity; CD4 antigen; CD4-Positive T-Lymphocytes - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell activation; Cell Line; Cell Line, Tumor; Dimerization; Effector cells; EMBO19; EMBO21; EMBO31; Glycolysis; Glycolysis - physiology; Growth factors; HEK293 Cells; Humans; Immunity; Kinases; Lymphocytes; Lymphocytes T; Mechanistic Target of Rapamycin Complex 1 - metabolism; Metabolic rate; Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; mTORC1; Nuclear Proteins - metabolism; Peli1; Proteins; Receptors, Antigen, T-Cell - metabolism; Signal transduction; T cell metabolism; antitumor immunity; T cell receptors; Tuberous Sclerosis Complex 1; Tuberous Sclerosis Complex 1 Protein - metabolism; Tuberous Sclerosis Complex 2; Tuberous Sclerosis Complex 2 Protein - metabolism; Tumorigenesis; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Peli1; T cell metabolism; antitumor immunity; ubiquitination; mTORC1