Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double‐blind, randomised, controlled trial

• Published in: The Journal of physiology Vol. 592; no. 8; pp. 1887 - 1901
• Main Authors: Paulsen, Gøran, Cumming, Kristoffer T., Holden, Geir, Hallén, Jostein, Rønnestad, Bent Ronny, Sveen, Ole, Skaug, Arne, Paur, Ingvild, Bastani, Nasser E., Østgaard, Hege Nymo, Buer, Charlotte, Midttun, Magnus, Freuchen, Fredrik, Wiig, Håvard, Ulseth, Elisabeth Tallaksen, Garthe, Ina, Blomhoff, Rune, Benestad, Haakon B., Raastad, Truls
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 15.04.2014; BlackWell Publishing Ltd
• Subjects: Adaptation, Physiological; Adult; Ascorbic Acid - administration & dosage; Ascorbic Acid - pharmacology; Biosynthesis; cdc42 GTP-Binding Protein - genetics; cdc42 GTP-Binding Protein - metabolism; Dietary Supplements; Double-Blind Method; Electron Transport Complex IV - genetics; Electron Transport Complex IV - metabolism; Exercise; Female; Humans; Integrative; Kinases; Male; Mitogen-Activated Protein Kinase 1 - genetics; Mitogen-Activated Protein Kinase 1 - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Oxygen Consumption - drug effects; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Endurance - drug effects; Transcription Factors - genetics; Transcription Factors - metabolism; Vitamin C; Vitamin E - administration & dosage; Vitamin E - pharmacology; Vitamins - administration & dosage; Vitamins - pharmacology

Key points Recent studies have indicated that antioxidant supplementation may blunt adaptations to exercise, such as mitochondrial biogenesis induced by endurance training. However, studies in humans are sparse and results are conflicting. Isolated vitamin C and E supplements are widely used, and un...