Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

• Published in: Immunological reviews Vol. 266; no. 1; pp. 56 - 71
• Main Authors: Yang, Xiao-Dong, Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2015
• Subjects: Animals; cIAP; Humans; inflammation; NF-kappa B - metabolism; NF-kappaB-Inducing Kinase; NIK; non-canonical NF-κB; Protein Serine-Threonine Kinases - metabolism; Proteolysis; Signal Transduction; TNF Receptor-Associated Factor 2 - metabolism; TNF Receptor-Associated Factor 3 - metabolism; TRAF2; TRAF3; NIK; TRAF2; cIAP; TRAF3; inflammation; non-canonical NF-κB

Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of in...