Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of in...

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Bibliographic Details
Published inImmunological reviews Vol. 266; no. 1; pp. 56 - 71
Main Authors Yang, Xiao-Dong, Sun, Shao-Cong
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.07.2015
Subjects
Animals
cIAP
Humans
inflammation
NF-kappa B - metabolism
NF-kappaB-Inducing Kinase
NIK
non-canonical NF-κB
Protein Serine-Threonine Kinases - metabolism
Proteolysis
Signal Transduction
TNF Receptor-Associated Factor 2 - metabolism
TNF Receptor-Associated Factor 3 - metabolism
TRAF2
TRAF3
NIK
TRAF2
cIAP
TRAF3
inflammation
non-canonical NF-κB
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Abstract Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well‐recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin‐dependent degradation of nuclear factor‐κB (NF‐κB)‐inducing kinase (NIK), an action required for the control of NIK‐regulated non‐canonical NF‐κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK‐binding adapter. Recent evidence suggests that the cIAP‐TRAF2‐TRAF3 E3 complex also targets additional signaling factors for ubiquitin‐dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
AbstractList Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well-recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin-dependent degradation of nuclear factor-κB (NF-κB)-inducing kinase (NIK), an action required for the control of NIK-regulated non-canonical NF-κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK-binding adapter. Recent evidence suggests that the cIAP-TRAF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well-recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin-dependent degradation of nuclear factor-κB (NF-κB)-inducing kinase (NIK), an action required for the control of NIK-regulated non-canonical NF-κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK-binding adapter. Recent evidence suggests that the cIAP-TRAF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well-recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin-dependent degradation of nuclear factor-κB (NF-κB)-inducing kinase (NIK), an action required for the control of NIK-regulated non-canonical NF-κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK-binding adapter. Recent evidence suggests that the cIAP-TRAF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well‐recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin‐dependent degradation of nuclear factor‐κB (NF‐κB)‐inducing kinase (NIK), an action required for the control of NIK‐regulated non‐canonical NF‐κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK‐binding adapter. Recent evidence suggests that the cIAP‐TRAF2‐TRAF3 E3 complex also targets additional signaling factors for ubiquitin‐dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However, emerging evidence suggests that TRAF proteins, particularly TRAF2 and TRAF3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well-recognized function of TRAF2 and TRAF3 in this aspect is to mediate ubiquitin-dependent degradation of NF-κB-inducing kinase (NIK), an action required for the control of NIK-regulated noncanonical NF-κB signaling pathway. TRAF2 and TRAF3 form a complex with the E3 ubiquitin ligase cIAP (cIAP1 or cIAP2), in which TRAF3 serves as the NIK-binding adapter. Recent evidence suggests that the cIAP-TRAF2-TRAF3 E3 complex also targets additional signaling factors for ubiquitin-dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
Tumor necrosis factor receptor ( TNFR )‐associated factors ( TRAF s) form a family of proteins that are best known as signaling adapters of TNFR s. However, emerging evidence suggests that TRAF proteins, particularly TRAF 2 and TRAF 3, also regulate signal transduction by controlling the fate of intracellular signaling factors. A well‐recognized function of TRAF 2 and TRAF 3 in this aspect is to mediate ubiquitin‐dependent degradation of nuclear factor‐κB ( NF ‐κB)‐inducing kinase ( NIK ), an action required for the control of NIK ‐regulated non‐canonical NF ‐κB signaling pathway. TRAF 2 and TRAF 3 form a complex with the E3 ubiquitin ligase cIAP ( cIAP 1 or cIAP 2), in which TRAF 3 serves as the NIK ‐binding adapter. Recent evidence suggests that the cIAP ‐ TRAF 2‐ TRAF 3 E3 complex also targets additional signaling factors for ubiquitin‐dependent degradation, thereby regulating important aspects of immune and inflammatory responses. This review provides both historical aspects and new insights into the signaling functions of this ubiquitination system.
Author Sun, Shao-Cong
Yang, Xiao-Dong
AuthorAffiliation 3 The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
1 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
AuthorAffiliation_xml – name: 1 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
– name: 3 The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
– name: 2 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Author_xml – sequence: 1
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  surname: Yang
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  organization: Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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  surname: Sun
  fullname: Sun, Shao-Cong
  email: ssun@mdanderson.org
  organization: Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26085207$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords NIK
TRAF2
cIAP
TRAF3
inflammation
non-canonical NF-κB
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Notes US National Institutes of Health - No. AI057555; No. AI064639; No. GM84459; No. AI104519
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PublicationTitle Immunological reviews
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Snippet Summary Tumor necrosis factor receptor (TNFR)‐associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However,...
Tumor necrosis factor receptor ( TNFR )‐associated factors ( TRAF s) form a family of proteins that are best known as signaling adapters of TNFR s. However,...
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) form a family of proteins that are best known as signaling adapters of TNFRs. However,...
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StartPage 56
SubjectTerms Animals
cIAP
Humans
inflammation
NF-kappa B - metabolism
NF-kappaB-Inducing Kinase
NIK
non-canonical NF-κB
Protein Serine-Threonine Kinases - metabolism
Proteolysis
Signal Transduction
TNF Receptor-Associated Factor 2 - metabolism
TNF Receptor-Associated Factor 3 - metabolism
TRAF2
TRAF3
Title Targeting signaling factors for degradation, an emerging mechanism for TRAF functions
URI https://api.istex.fr/ark:/67375/WNG-T3BVBPC2-S/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fimr.12311
https://www.ncbi.nlm.nih.gov/pubmed/26085207
https://www.proquest.com/docview/1690210493
https://pubmed.ncbi.nlm.nih.gov/PMC4473799
Volume 266
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