NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in Han Chinese

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 64; no. 3; pp. 647 - 654
• Main Authors: Sui, Jiangdong, Li, Hua, Fang, Yongfei, Liu, Yang, Li, Minhui, Zhong, Bing, Yang, Fei, Zou, Qiang, Wu, Yuzhang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2012; Wiley; Wiley Subscription Services, Inc
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Apoptosis Regulatory Proteins - genetics; Arthritis, Rheumatoid - ethnology; Arthritis, Rheumatoid - genetics; Asian Continental Ancestry Group - genetics; Autoimmune diseases; Binding sites; Biological and medical sciences; China - epidemiology; Diseases of the osteoarticular system; Female; Genes; Genetic Predisposition to Disease; Genotype; HeLa Cells; Humans; Inflammatory joint diseases; Linkage Disequilibrium; Male; Medical research; Medical sciences; Polymorphism, Single Nucleotide; Rheumatoid arthritis; Transcription, Genetic; Up-Regulation; China; Immunopathology; Chronic; Rheumatoid arthritis; Diseases of the osteoarticular system; Risk factor; Rheumatology; Autoimmune disease; Inflammatory joint disease; Transcription factor; Polymorphism

Objective The inflammasome‐related protein NLRP1/NALP1 has been implicated in the onset and progression of some autoimmune diseases. This study was undertaken to determine whether a polymorphism in the NLRP1 gene is associated with susceptibility to rheumatoid arthritis (RA) in Han Chinese and to as...