Direct Borylation of Primary CH Bonds in Functionalized Molecules by Palladium Catalysis

• Published in: Angewandte Chemie International Edition Vol. 53; no. 15; pp. 3899 - 3903
• Main Authors: Zhang, Li-Sheng, Chen, Guihua, Wang, Xin, Guo, Qing-Yun, Zhang, Xi-Sha, Pan, Fei, Chen, Kang, Shi, Zhang-Jie
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 07.04.2014; WILEY‐VCH Verlag; Wiley
• Subjects: Additives; Alcohols; Amines; Amino acids; borylation; Chemistry; Chemistry, Multidisciplinary; Conversion; CH functionalization; directing groups; Esters; Ligands; palladium; Physical Sciences; Science & Technology; Terminals; C(SP)-H BONDS; ACTIVATION; OXYGENATION; ALKYLATION; amino acids; borylation; ARYLATION; COMPLEXES; PINACOLBORANE; UNACTIVATED C(SP)-H BONDS; AMINATION; CH functionalization; palladium; directing groups; ALKANES; CH functionalization

Organoborane compounds are among the most commonly employed intermediates in organic synthesis and serve as crucial precursors to alcohols, amines, and various functionalized molecules. A simple palladium‐based system catalyzes the conversion of primary C(sp3)H bonds in functionalized complex organ...