Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy

• Published in: Journal of gastroenterology and hepatology Vol. 28; no. S1; pp. 77 - 84
• Main Authors: Orman, Eric S, Odena, Gemma, Bataller, Ramon
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.08.2013
• Subjects: alcoholic liver diseases; Animals; Chemokines, CXC; Diazomethane - analogs & derivatives; Disease Models, Animal; Endocannabinoids; Fatty Acids; fibrosis; Humans; Inflammasomes; inflammation; Interleukin-22; Interleukins; Intestines - microbiology; Lipopolysaccharides; Liver Diseases, Alcoholic - etiology; Liver Diseases, Alcoholic - genetics; Liver Diseases, Alcoholic - therapy; Molecular Targeted Therapy; Osteopontin; Receptors, Tumor Necrosis Factor; STAT3 Transcription Factor; translational research; Translational Research, Biomedical; fibrosis; translational research; inflammation; alcoholic liver diseases

Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirr...