The folate pathway is a target for resistance to the drug para‐aminosalicylic acid (PAS) in mycobacteria

• Published in: Molecular microbiology Vol. 53; no. 1; pp. 275 - 282
• Main Authors: Rengarajan, Jyothi, Sassetti, Christopher M., Naroditskaya, Vera, Sloutsky, Alexander, Bloom, Barry R., Rubin, Eric J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2004; Blackwell Science; Blackwell Publishing Ltd
• Subjects: Aminosalicylic Acid - administration & dosage; Aminosalicylic Acid - blood; Aminosalicylic Acid - pharmacology; Biological and medical sciences; Drug Resistance, Bacterial - genetics; Drug Resistance, Multiple - genetics; Folic Acid - metabolism; Folic Acid Antagonists; Fundamental and applied biological sciences. Psychology; Microbial Sensitivity Tests; Microbiology; Mutation; Mycobacterium bovis; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Tuberculosis, Multidrug-Resistant - microbiology; Resistance; Mycobacterium; Microbiology; Mycobacteriales; Mycobacteriaceae; Bacteria; Aminosalicylic acid; Actinomycetes; Antituberculous agent; Antibacterial agent; Folate

Summary The increasing rate of multidrug‐resistant tuberculosis has led to more use of second‐line antibiotics such as para‐aminosalicylic acid (PAS). The mode of action of PAS remains unclear, and mechanisms of resistance to this drug are undefined. We have isolated PAS‐resistant transposon mutants...