Neonatal intrahippocampal gp120 injection: An examination early in development

• Published in: Neurotoxicology (Park Forest South) Vol. 28; no. 1; pp. 101 - 107
• Main Authors: Fitting, Sylvia, Booze, Rosemarie M., Mactutus, Charles F.
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier B.V 01.01.2007; Elsevier
• Subjects: Animals; Animals, Newborn - physiology; Behavior, Animal - drug effects; Biological and medical sciences; Body Weight - drug effects; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Gp120; Hippocampus; Hippocampus - drug effects; Hippocampus - growth & development; HIV Envelope Protein gp120 - administration & dosage; HIV Envelope Protein gp120 - pharmacology; HIV-1; Human immunodeficiency virus 1; Human viral diseases; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Injections; Male; Medical sciences; Postural Balance - drug effects; Preattentive processes; Pregnancy; Prepulse inhibition; Psychomotor Performance - drug effects; Rats; Rats, Sprague-Dawley; Reflex - drug effects; Reflex, Startle - drug effects; Sensory-motor system; Toxicology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; HIV-1; Sensory-motor system; Gp120; Preattentive processes; Hippocampus; Prepulse inhibition; Immunopathology; Neonatal; HIV-1 virus; Central nervous system; Retroviridae; AIDS; Injection; Immune deficiency; Lentivirus; Encephalon; Infection; Virus; Viral disease; Development; Early; Inhibitor; Human immunodeficiency virus; Inhibition; Gpl20

The presence of human immunodeficiency virus type 1 (HIV-1) in the brain is believed to be responsible for mediating the pathogenesis of neurological abnormalities through the viral toxins gp120 and Tat. Numerous studies indicate neurotoxic effects of the HIV-1-protein Tat, with demonstrated neurobe...