Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conf...

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Published inNature communications Vol. 14; no. 1; p. 6804
Main Authors Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.10.2023
Nature Publishing Group
Nature Portfolio
Subjects
101/28
13
13/106
13/109
13/95
631/45
631/535/1258
631/535/1266
631/57
631/80/82/2344
82/16
82/58
82/83
Assembly
Cell death
Conformation
Dimerization
Electron microscopy
Humanities and Social Sciences
Inflammation
Kinases
Lung diseases
multidisciplinary
Necroptosis
Nucleation
Oligomerization
Phosphorylation
Science
Science (multidisciplinary)
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Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conformation change and oligomerization of the terminal pathway effector, MLKL, are only emerging. Here, we structurally identify RIPK3-mediated phosphorylation of the human MLKL activation loop as a cue for MLKL pseudokinase domain dimerization. MLKL pseudokinase domain dimerization subsequently drives formation of elongated homotetramers. Negative stain electron microscopy and modelling support nucleation of the MLKL tetramer assembly by a central coiled coil formed by the extended, ~80 Å brace helix that connects the pseudokinase and executioner four-helix bundle domains. Mutational data assert MLKL tetramerization as an essential prerequisite step to enable the release and reorganization of four-helix bundle domains for membrane permeabilization and cell death. How the necroptosis executioner, MLKL, converts to a killer form has been mysterious. Here, authors show RIPK3-mediated phosphorylation of human MLKL is the cue for pseudokinase domain dimerization before assembly of pro-necroptotic MLKL tetramers.
AbstractList The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conformation change and oligomerization of the terminal pathway effector, MLKL, are only emerging. Here, we structurally identify RIPK3-mediated phosphorylation of the human MLKL activation loop as a cue for MLKL pseudokinase domain dimerization. MLKL pseudokinase domain dimerization subsequently drives formation of elongated homotetramers. Negative stain electron microscopy and modelling support nucleation of the MLKL tetramer assembly by a central coiled coil formed by the extended, ~80 Å brace helix that connects the pseudokinase and executioner four-helix bundle domains. Mutational data assert MLKL tetramerization as an essential prerequisite step to enable the release and reorganization of four-helix bundle domains for membrane permeabilization and cell death. How the necroptosis executioner, MLKL, converts to a killer form has been mysterious. Here, authors show RIPK3-mediated phosphorylation of human MLKL is the cue for pseudokinase domain dimerization before assembly of pro-necroptotic MLKL tetramers.
The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conformation change and oligomerization of the terminal pathway effector, MLKL, are only emerging. Here, we structurally identify RIPK3-mediated phosphorylation of the human MLKL activation loop as a cue for MLKL pseudokinase domain dimerization. MLKL pseudokinase domain dimerization subsequently drives formation of elongated homotetramers. Negative stain electron microscopy and modelling support nucleation of the MLKL tetramer assembly by a central coiled coil formed by the extended, ~80 Å brace helix that connects the pseudokinase and executioner four-helix bundle domains. Mutational data assert MLKL tetramerization as an essential prerequisite step to enable the release and reorganization of four-helix bundle domains for membrane permeabilization and cell death.
The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conformation change and oligomerization of the terminal pathway effector, MLKL, are only emerging. Here, we structurally identify RIPK3-mediated phosphorylation of the human MLKL activation loop as a cue for MLKL pseudokinase domain dimerization. MLKL pseudokinase domain dimerization subsequently drives formation of elongated homotetramers. Negative stain electron microscopy and modelling support nucleation of the MLKL tetramer assembly by a central coiled coil formed by the extended, ~80 Å brace helix that connects the pseudokinase and executioner four-helix bundle domains. Mutational data assert MLKL tetramerization as an essential prerequisite step to enable the release and reorganization of four-helix bundle domains for membrane permeabilization and cell death.How the necroptosis executioner, MLKL, converts to a killer form has been mysterious. Here, authors show RIPK3-mediated phosphorylation of human MLKL is the cue for pseudokinase domain dimerization before assembly of pro-necroptotic MLKL tetramers.
Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway, where the RIPK3 kinase phosphorylates and triggers a conformation change and oligomerization of the terminal pathway effector, MLKL, are only emerging. Here, we structurally identify RIPK3-mediated phosphorylation of the human MLKL activation loop as a cue for MLKL pseudokinase domain dimerization. MLKL pseudokinase domain dimerization subsequently drives formation of elongated homotetramers. Negative stain electron microscopy and modelling support nucleation of the MLKL tetramer assembly by a central coiled coil formed by the extended, ~80 Å brace helix that connects the pseudokinase and executioner four-helix bundle domains. Mutational data assert MLKL tetramerization as an essential prerequisite step to enable the release and reorganization of four-helix bundle domains for membrane permeabilization and cell death.
ArticleNumber 6804
Author Fitzgibbon, Cheree
Garnish, Sarah E.
Hildebrand, Joanne M.
Dite, Toby
Murphy, James M.
Black, Katrina A.
Leis, Andrew P.
Horne, Christopher R.
Koide, Akiko
Venkat, Aarya
Dagley, Laura F.
Czabotar, Peter E.
Glukhova, Alisa
Davies, Katherine A.
Meng, Yanxiang
Kannan, Natarajan
Young, Samuel N.
Koide, Shohei
Hoblos, Hanadi
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Cites_doi 10.1016/j.immuni.2013.06.018
10.1021/acs.jmedchem.1c00686
10.1107/S0907444910007493
10.1038/s41467-018-04714-7
10.1107/S0021889807021206
10.1073/pnas.1707531114
10.1073/pnas.1408987111
10.1016/j.cell.2009.05.037
10.1038/nmicrobiol.2016.258
10.1126/scisignal.abc6178
10.1021/ct500864r
10.1371/journal.pone.0063090
10.1038/cr.2016.26
10.1016/j.chembiol.2019.03.010
10.1042/BJ20131270
10.1038/s41419-021-03859-6
10.1074/jbc.M601553200
10.1038/s41467-020-16819-z
10.1016/j.cell.2018.03.032
10.1371/journal.pone.0059004
10.1021/acschembio.0c00482
10.1107/S0907444909042073
10.1107/S0907444909047374
10.1107/S2059798316017174
10.1038/s41581-022-00658-w
10.1107/S1600576720013412
10.1038/82732
10.1016/j.immuni.2020.11.020
10.1016/j.tcb.2022.05.008
10.1107/S1600576717017101
10.1038/s41467-020-16823-3
10.1016/j.tibs.2018.12.002
10.1016/j.cell.2012.06.019
10.1042/BCJ20210604
10.1016/j.tibs.2018.11.002
10.1073/pnas.0607656103
10.1016/j.molcel.2016.01.011
10.1016/bs.mie.2022.03.029
10.1016/j.cell.2007.10.037
10.1371/journal.pone.0165983
10.1093/protein/11.9.739
10.1038/s41596-018-0068-8
10.1038/s41418-022-00965-6
10.1107/S0907444910026582
10.1038/nature13608
10.1073/pnas.1919960117
10.1038/cdd.2015.169
10.1038/nbt.1511
10.1038/s41418-021-00742-x
10.1074/mcp.TIR118.001209
10.1074/jbc.M113.462341
10.1038/s41467-021-22400-z
10.1073/pnas.2017406117
10.1107/S0907444913000061
10.1021/pr101065j
10.1038/s41419-022-05009-y
10.1016/j.celrep.2019.08.055
10.1038/s41418-020-00722-7
10.1016/j.molcel.2019.03.028
10.1038/s41418-022-01042-8
10.1038/ajg.2013.403
10.1007/s00018-017-2547-4
10.1038/ncb2883
10.1038/nprot.2007.261
10.1038/s41418-018-0061-3
10.1016/j.celrep.2014.04.026
10.1016/j.jmb.2007.05.022
10.1016/j.kint.2019.02.009
10.1164/rccm.202009-3442OC
10.1016/j.molcel.2014.03.003
10.1038/s41467-020-16887-1
10.1016/j.str.2014.07.014
10.1038/s41592-022-01488-1
10.1038/nature20558
10.1107/S1600577518003120
10.1016/j.celrep.2016.07.039
10.1038/nature20559
10.1073/pnas.2001887117
10.1042/BCJ20210606
10.1128/MCB.00497-16
10.1371/journal.ppat.1008473
10.1038/s41467-021-27032-x
10.1016/j.str.2013.01.016
10.1002/pro.3943
10.1016/j.cell.2011.11.031
10.1016/j.celrep.2013.08.044
10.3390/biom11060803
10.1038/s41467-023-41724-6
10.1084/jem.20191259
10.1016/j.jbc.2023.104792
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springer_journals_10_1038_s41467_023_42255_w
PublicationCentury 2000
PublicationDate 2023-10-26
PublicationDateYYYYMMDD 2023-10-26
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-26
  day: 26
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Gógl, Kornev, Reményi, Taylor (CR57) 2019; 44
Nivon, Moretti, Baker (CR61) 2013; 8
Xie (CR54) 2013; 5
Meng (CR29) 2021; 12
Murphy (CR42) 2014; 457
Rübbelke (CR65) 2021; 64
Afonine (CR74) 2010; 66
Kaiser (CR23) 2013; 288
Xie (CR45) 2013; 21
Steain (CR8) 2020; 16
Pefanis, Ierino, Murphy, Cowan (CR19) 2019; 96
Vince (CR27) 2007; 131
Hildebrand (CR10) 2020; 11
Garnish (CR33) 2021; 12
Dondelinger (CR48) 2014; 7
Bossen (CR90) 2006; 281
Pettersen (CR77) 2021; 30
Davies (CR36) 2020; 11
Petrie, Czabotar, Murphy (CR39) 2019; 44
Sethi (CR50) 2022; 29
Sun (CR30) 2012; 148
Mirdita (CR60) 2022; 19
Quarato (CR49) 2016; 61
Petrie (CR59) 2020; 117
Tanzer (CR41) 2016; 23
CR7
Samson (CR34) 2020; 11
Horne, Samson, Murphy (CR26) 2023; 33
McNamara (CR64) 2019; 26
CR9
Cho (CR1) 2009; 137
Kabsch (CR71) 2010; 66
Fitzgibbon, Meng, Murphy (CR69) 2022; 667
Manalastas-Cantos (CR80) 2021; 54
Dannappel (CR13) 2014; 513
Newton (CR24) 2016; 540
Meng (CR66) 2022; 13
Liu (CR68) 2017; 114
O’Meara (CR88) 2015; 11
Lin (CR16) 2016; 540
Kornev, Haste, Taylor, Ten Eyck (CR53) 2006; 103
Iacobucci (CR83) 2018; 13
Kolbrink, von Samson-Himmelstjerna, Murphy, Krautwald (CR17) 2023; 19
Rubbelke (CR63) 2020; 117
Holler (CR21) 2000; 1
Samson, Garnish, Hildebrand, Murphy (CR22) 2021; 14
Aragao (CR70) 2018; 25
Shindyalov, Bourne (CR86) 1998; 11
Pierotti (CR56) 2020; 15
Bader (CR12) 2023; 30
Cox (CR84) 2011; 10
Ryan (CR79) 2018; 51
Stein, Kortemme (CR87) 2013; 8
Pearson (CR5) 2017; 2
CR11
Cai (CR47) 2014; 16
Huang (CR58) 2017; 37
Nakano, Murai, Moriwaki (CR35) 2022; 479
Cox, Mann (CR82) 2008; 26
McCoy (CR73) 2007; 40
Mompean (CR44) 2018; 173
Hildebrand (CR38) 2014; 111
Su (CR43) 2014; 22
Chen (CR76) 2010; 66
Brademan, Riley, Kwiecien, Coon (CR85) 2019; 18
Anderton, Alqudah (CR15) 2022; 479
Ding (CR46) 2019; 74
Samson (CR89) 2021; 28
Li (CR25) 2012; 150
Petrie (CR40) 2018; 9
Ma (CR55) 2016; 11
Kirby (CR78) 2016; 72
Emsley, Lohkamp, Scott, Cowtan (CR75) 2010; 66
Liu (CR4) 2021; 54
CR28
Rappsilber, Mann, Ishihama (CR81) 2007; 2
Krissinel, Henrick (CR51) 2007; 372
Murphy (CR32) 2013; 39
Kitur (CR3) 2016; 16
Lu (CR20) 2021; 204
Wang (CR67) 2014; 54
Fletcher-Etherington (CR2) 2020; 117
Muller (CR18) 2017; 74
Meng, Sandow, Czabotar, Murphy (CR31) 2021; 28
Zhang (CR52) 2021; 12
Petrie (CR6) 2019; 28
Davies (CR37) 2018; 25
Pierdomenico (CR14) 2014; 109
Evans, Murshudov (CR72) 2013; 69
Xia (CR62) 2016; 26
DR Brademan (42255_CR85) 2019; 18
SM Bader (42255_CR12) 2023; 30
Z Lu (42255_CR20) 2021; 204
Y Meng (42255_CR29) 2021; 12
Y Dondelinger (42255_CR48) 2014; 7
EF Pettersen (42255_CR77) 2021; 30
Z Liu (42255_CR4) 2021; 54
Y Meng (42255_CR66) 2022; 13
JM Hildebrand (42255_CR10) 2020; 11
AL Samson (42255_CR22) 2021; 14
EJ Petrie (42255_CR6) 2019; 28
DE McNamara (42255_CR64) 2019; 26
K Kitur (42255_CR3) 2016; 16
M Mompean (42255_CR44) 2018; 173
M Dannappel (42255_CR13) 2014; 513
JE Vince (42255_CR27) 2007; 131
E Krissinel (42255_CR51) 2007; 372
YS Cho (42255_CR1) 2009; 137
42255_CR7
JM Murphy (42255_CR42) 2014; 457
Z Cai (42255_CR47) 2014; 16
G Quarato (42255_CR49) 2016; 61
42255_CR9
CL Pierotti (42255_CR56) 2020; 15
TM Ryan (42255_CR79) 2018; 51
42255_CR11
EJ Petrie (42255_CR39) 2019; 44
N Kirby (42255_CR78) 2016; 72
C Iacobucci (42255_CR83) 2018; 13
Y Zhang (42255_CR52) 2021; 12
L Su (42255_CR43) 2014; 22
L Sun (42255_CR30) 2012; 148
VB Chen (42255_CR76) 2010; 66
PR Evans (42255_CR72) 2013; 69
JM Murphy (42255_CR32) 2013; 39
W Kabsch (42255_CR71) 2010; 66
N Holler (42255_CR21) 2000; 1
T Xie (42255_CR45) 2013; 21
H Wang (42255_CR67) 2014; 54
C Bossen (42255_CR90) 2006; 281
M Pierdomenico (42255_CR14) 2014; 109
Y Meng (42255_CR31) 2021; 28
PV Afonine (42255_CR74) 2010; 66
B Ma (42255_CR55) 2016; 11
K Newton (42255_CR24) 2016; 540
J Cox (42255_CR84) 2011; 10
G Gógl (42255_CR57) 2019; 44
SE Garnish (42255_CR33) 2021; 12
KA Davies (42255_CR36) 2020; 11
T Xie (42255_CR54) 2013; 5
EJ Petrie (42255_CR40) 2018; 9
D Huang (42255_CR58) 2017; 37
IN Shindyalov (42255_CR86) 1998; 11
A Sethi (42255_CR50) 2022; 29
EJ Petrie (42255_CR59) 2020; 117
K Manalastas-Cantos (42255_CR80) 2021; 54
A Stein (42255_CR87) 2013; 8
JS Pearson (42255_CR5) 2017; 2
S Liu (42255_CR68) 2017; 114
CR Horne (42255_CR26) 2023; 33
H Anderton (42255_CR15) 2022; 479
AL Samson (42255_CR89) 2021; 28
WJ Kaiser (42255_CR23) 2013; 288
J Lin (42255_CR16) 2016; 540
M Rübbelke (42255_CR65) 2021; 64
C Fitzgibbon (42255_CR69) 2022; 667
MJ O’Meara (42255_CR88) 2015; 11
AP Kornev (42255_CR53) 2006; 103
A Fletcher-Etherington (42255_CR2) 2020; 117
LG Nivon (42255_CR61) 2013; 8
MC Tanzer (42255_CR41) 2016; 23
M Steain (42255_CR8) 2020; 16
AL Samson (42255_CR34) 2020; 11
T Muller (42255_CR18) 2017; 74
B Xia (42255_CR62) 2016; 26
B Kolbrink (42255_CR17) 2023; 19
D Aragao (42255_CR70) 2018; 25
M Mirdita (42255_CR60) 2022; 19
J Cox (42255_CR82) 2008; 26
M Rubbelke (42255_CR63) 2020; 117
A Pefanis (42255_CR19) 2019; 96
H Nakano (42255_CR35) 2022; 479
KA Davies (42255_CR37) 2018; 25
J Rappsilber (42255_CR81) 2007; 2
JM Hildebrand (42255_CR38) 2014; 111
J Li (42255_CR25) 2012; 150
AJ McCoy (42255_CR73) 2007; 40
42255_CR28
J Ding (42255_CR46) 2019; 74
P Emsley (42255_CR75) 2010; 66
References_xml – volume: 39
  start-page: 443
  year: 2013
  end-page: 453
  ident: CR32
  article-title: The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
  contributor:
    fullname: Murphy
– volume: 64
  start-page: 15629
  year: 2021
  end-page: 15638
  ident: CR65
  article-title: Discovery and structure-based optimization of fragments binding the mixed lineage kinase domain-like protein executioner domain
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.1c00686
  contributor:
    fullname: Rübbelke
– volume: 66
  start-page: 486
  year: 2010
  end-page: 501
  ident: CR75
  article-title: Features and development of Coot
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444910007493
  contributor:
    fullname: Cowtan
– volume: 9
  year: 2018
  ident: CR40
  article-title: Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04714-7
  contributor:
    fullname: Petrie
– volume: 40
  start-page: 658
  year: 2007
  end-page: 674
  ident: CR73
  article-title: Phaser crystallographic software
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S0021889807021206
  contributor:
    fullname: McCoy
– volume: 114
  start-page: E7450
  year: 2017
  end-page: E7459
  ident: CR68
  article-title: MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707531114
  contributor:
    fullname: Liu
– volume: 111
  start-page: 15072
  year: 2014
  end-page: 15077
  ident: CR38
  article-title: Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1408987111
  contributor:
    fullname: Hildebrand
– volume: 137
  start-page: 1112
  year: 2009
  end-page: 1123
  ident: CR1
  article-title: Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
  publication-title: Cell
  doi: 10.1016/j.cell.2009.05.037
  contributor:
    fullname: Cho
– volume: 2
  start-page: 16258
  year: 2017
  ident: CR5
  article-title: EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2016.258
  contributor:
    fullname: Pearson
– volume: 14
  start-page: eabc6178
  year: 2021
  ident: CR22
  article-title: Location, location, location: a compartmentalized view of TNF-induced necroptotic signaling
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.abc6178
  contributor:
    fullname: Murphy
– volume: 11
  start-page: 609
  year: 2015
  end-page: 622
  ident: CR88
  article-title: Combined covalent-electrostatic model of hydrogen bonding improves structure prediction with Rosetta
  publication-title: J. Chem. Theory Comput.
  doi: 10.1021/ct500864r
  contributor:
    fullname: O’Meara
– volume: 8
  start-page: e63090
  year: 2013
  ident: CR87
  article-title: Improvements to robotics-inspired conformational sampling in rosetta
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0063090
  contributor:
    fullname: Kortemme
– volume: 26
  start-page: 517
  year: 2016
  end-page: 528
  ident: CR62
  article-title: MLKL forms cation channels
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.26
  contributor:
    fullname: Xia
– volume: 26
  start-page: 863.e7
  year: 2019
  end-page: 877.e7
  ident: CR64
  article-title: Direct activation of human MLKL by a select repertoire of inositol phosphate metabolites
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.03.010
  contributor:
    fullname: McNamara
– volume: 457
  start-page: 369
  year: 2014
  end-page: 377
  ident: CR42
  article-title: Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
  publication-title: Biochem. J.
  doi: 10.1042/BJ20131270
  contributor:
    fullname: Murphy
– volume: 12
  year: 2021
  ident: CR52
  article-title: The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-021-03859-6
  contributor:
    fullname: Zhang
– volume: 281
  start-page: 13964
  year: 2006
  end-page: 13971
  ident: CR90
  article-title: Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M601553200
  contributor:
    fullname: Bossen
– volume: 11
  year: 2020
  ident: CR10
  article-title: A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16819-z
  contributor:
    fullname: Hildebrand
– volume: 173
  start-page: 1244.e10
  year: 2018
  end-page: 1253.e10
  ident: CR44
  article-title: The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.032
  contributor:
    fullname: Mompean
– volume: 8
  start-page: e59004
  year: 2013
  ident: CR61
  article-title: A Pareto-optimal refinement method for protein design scaffolds
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0059004
  contributor:
    fullname: Baker
– volume: 15
  start-page: 2702
  year: 2020
  end-page: 2713
  ident: CR56
  article-title: Potent inhibition of necroptosis by simultaneously targeting multiple effectors of the pathway
  publication-title: ACS Chem. Biol.
  doi: 10.1021/acschembio.0c00482
  contributor:
    fullname: Pierotti
– volume: 66
  start-page: 12
  year: 2010
  end-page: 21
  ident: CR76
  article-title: MolProbity: all-atom structure validation for macromolecular crystallography
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909042073
  contributor:
    fullname: Chen
– volume: 66
  start-page: 133
  year: 2010
  end-page: 144
  ident: CR71
  article-title: Integration, scaling, space-group assignment and post-refinement
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909047374
  contributor:
    fullname: Kabsch
– volume: 72
  start-page: 1254
  year: 2016
  end-page: 1266
  ident: CR78
  article-title: Improved radiation dose efficiency in solution SAXS using a sheath flow sample environment
  publication-title: Acta Crystallogr. D Struct. Biol.
  doi: 10.1107/S2059798316017174
  contributor:
    fullname: Kirby
– volume: 19
  start-page: 300
  year: 2023
  end-page: 314
  ident: CR17
  article-title: Role of necroptosis in kidney health and disease
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-022-00658-w
  contributor:
    fullname: Krautwald
– volume: 54
  start-page: 343
  year: 2021
  end-page: 355
  ident: CR80
  article-title: ATSAS 3.0: expanded functionality and new tools for small-angle scattering data analysis
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S1600576720013412
  contributor:
    fullname: Manalastas-Cantos
– volume: 1
  start-page: 489
  year: 2000
  end-page: 495
  ident: CR21
  article-title: Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
  publication-title: Nat. Immunol.
  doi: 10.1038/82732
  contributor:
    fullname: Holler
– volume: 54
  start-page: 247.e7
  year: 2021
  end-page: 258.e7
  ident: CR4
  article-title: A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.11.020
  contributor:
    fullname: Liu
– ident: CR11
– volume: 33
  start-page: 162
  year: 2023
  end-page: 174
  ident: CR26
  article-title: The web of death: the expanding complexity of necroptotic signaling
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2022.05.008
  contributor:
    fullname: Murphy
– ident: CR9
– volume: 51
  start-page: 97
  year: 2018
  end-page: 111
  ident: CR79
  article-title: An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S1600576717017101
  contributor:
    fullname: Ryan
– volume: 11
  year: 2020
  ident: CR36
  article-title: Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16823-3
  contributor:
    fullname: Davies
– volume: 44
  start-page: 300
  year: 2019
  end-page: 311
  ident: CR57
  article-title: Disordered protein kinase regions in regulation of kinase domain cores
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2018.12.002
  contributor:
    fullname: Taylor
– volume: 150
  start-page: 339
  year: 2012
  end-page: 350
  ident: CR25
  article-title: The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
  publication-title: Cell
  doi: 10.1016/j.cell.2012.06.019
  contributor:
    fullname: Li
– volume: 479
  start-page: 677
  year: 2022
  end-page: 685
  ident: CR35
  article-title: Regulation of the release of damage-associated molecular patterns from necroptotic cells
  publication-title: Biochem. J.
  doi: 10.1042/BCJ20210604
  contributor:
    fullname: Moriwaki
– volume: 44
  start-page: 53
  year: 2019
  end-page: 63
  ident: CR39
  article-title: The structural basis of necroptotic cell death signaling
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2018.11.002
  contributor:
    fullname: Murphy
– volume: 103
  start-page: 17783
  year: 2006
  end-page: 17788
  ident: CR53
  article-title: Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0607656103
  contributor:
    fullname: Ten Eyck
– volume: 61
  start-page: 589
  year: 2016
  end-page: 601
  ident: CR49
  article-title: Sequential engagement of distinct MLKL phosphatidylinositol-binding sites executes necroptosis
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.01.011
  contributor:
    fullname: Quarato
– volume: 667
  start-page: 183
  year: 2022
  end-page: 227
  ident: CR69
  article-title: Co-expression of recombinant RIPK3:MLKL complexes using the baculovirus-insect cell system
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2022.03.029
  contributor:
    fullname: Murphy
– volume: 131
  start-page: 682
  year: 2007
  end-page: 693
  ident: CR27
  article-title: IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
  publication-title: Cell
  doi: 10.1016/j.cell.2007.10.037
  contributor:
    fullname: Vince
– volume: 11
  start-page: e0165983
  year: 2016
  ident: CR55
  article-title: ATP-competitive MLKL binders have no functional impact on necroptosis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0165983
  contributor:
    fullname: Ma
– volume: 11
  start-page: 739
  year: 1998
  end-page: 747
  ident: CR86
  article-title: Protein structure alignment by incremental combinatorial extension (CE) of the optimal path
  publication-title: Protein Eng.
  doi: 10.1093/protein/11.9.739
  contributor:
    fullname: Bourne
– volume: 13
  start-page: 2864
  year: 2018
  end-page: 2889
  ident: CR83
  article-title: A cross-linking/mass spectrometry workflow based on MS-cleavable cross-linkers and the MeroX software for studying protein structures and protein-protein interactions
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-018-0068-8
  contributor:
    fullname: Iacobucci
– volume: 29
  start-page: 1804
  year: 2022
  end-page: 1815
  ident: CR50
  article-title: Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-022-00965-6
  contributor:
    fullname: Sethi
– volume: 66
  start-page: 1153
  year: 2010
  end-page: 1163
  ident: CR74
  article-title: Joint X-ray and neutron refinement with phenix.refine
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444910026582
  contributor:
    fullname: Afonine
– volume: 513
  start-page: 90
  year: 2014
  end-page: 94
  ident: CR13
  article-title: RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
  publication-title: Nature
  doi: 10.1038/nature13608
  contributor:
    fullname: Dannappel
– volume: 117
  start-page: 8468
  year: 2020
  end-page: 8475
  ident: CR59
  article-title: Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1919960117
  contributor:
    fullname: Petrie
– volume: 23
  start-page: 1185
  year: 2016
  end-page: 1197
  ident: CR41
  article-title: Evolutionary divergence of the necroptosis effector MLKL
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2015.169
  contributor:
    fullname: Tanzer
– volume: 26
  start-page: 1367
  year: 2008
  end-page: 1372
  ident: CR82
  article-title: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
  contributor:
    fullname: Mann
– volume: 28
  start-page: 2126
  year: 2021
  end-page: 2144
  ident: CR89
  article-title: A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-021-00742-x
  contributor:
    fullname: Samson
– volume: 18
  start-page: S193
  year: 2019
  end-page: S201
  ident: CR85
  article-title: Interactive peptide spectral annotator: a versatile web-based tool for proteomic applications
  publication-title: Mol. Cell. Proteomics
  doi: 10.1074/mcp.TIR118.001209
  contributor:
    fullname: Coon
– volume: 288
  start-page: 31268
  year: 2013
  end-page: 31279
  ident: CR23
  article-title: Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.462341
  contributor:
    fullname: Kaiser
– volume: 12
  year: 2021
  ident: CR33
  article-title: Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22400-z
  contributor:
    fullname: Garnish
– volume: 117
  start-page: 33272
  year: 2020
  end-page: 33281
  ident: CR63
  article-title: Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2017406117
  contributor:
    fullname: Rubbelke
– volume: 69
  start-page: 1204
  year: 2013
  end-page: 1214
  ident: CR72
  article-title: How good are my data and what is the resolution?
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444913000061
  contributor:
    fullname: Murshudov
– volume: 10
  start-page: 1794
  year: 2011
  end-page: 1805
  ident: CR84
  article-title: Andromeda: a peptide search engine integrated into the MaxQuant environment
  publication-title: J. Proteome Res.
  doi: 10.1021/pr101065j
  contributor:
    fullname: Cox
– volume: 13
  start-page: 565
  year: 2022
  ident: CR66
  article-title: Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-05009-y
  contributor:
    fullname: Meng
– volume: 28
  start-page: 3309.e5
  year: 2019
  end-page: 3319.e5
  ident: CR6
  article-title: Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.08.055
  contributor:
    fullname: Petrie
– volume: 28
  start-page: 861
  year: 2021
  end-page: 883
  ident: CR31
  article-title: The regulation of necroptosis by post-translational modifications
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-020-00722-7
  contributor:
    fullname: Murphy
– volume: 74
  start-page: 922.e6
  year: 2019
  end-page: 935.e6
  ident: CR46
  article-title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2019.03.028
  contributor:
    fullname: Ding
– volume: 30
  start-page: 27
  year: 2023
  end-page: 36
  ident: CR12
  article-title: Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-022-01042-8
  contributor:
    fullname: Bader
– volume: 109
  start-page: 279
  year: 2014
  end-page: 287
  ident: CR14
  article-title: Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2013.403
  contributor:
    fullname: Pierdomenico
– volume: 74
  start-page: 3631
  year: 2017
  end-page: 3645
  ident: CR18
  article-title: Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-017-2547-4
  contributor:
    fullname: Muller
– volume: 16
  start-page: 55
  year: 2014
  end-page: 65
  ident: CR47
  article-title: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2883
  contributor:
    fullname: Cai
– volume: 2
  start-page: 1896
  year: 2007
  end-page: 1906
  ident: CR81
  article-title: Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.261
  contributor:
    fullname: Ishihama
– volume: 25
  start-page: 1567
  year: 2018
  end-page: 1580
  ident: CR37
  article-title: The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-018-0061-3
  contributor:
    fullname: Davies
– volume: 7
  start-page: 971
  year: 2014
  end-page: 981
  ident: CR48
  article-title: MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.04.026
  contributor:
    fullname: Dondelinger
– volume: 372
  start-page: 774
  year: 2007
  end-page: 797
  ident: CR51
  article-title: Inference of macromolecular assemblies from crystalline state
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2007.05.022
  contributor:
    fullname: Henrick
– volume: 96
  start-page: 291
  year: 2019
  end-page: 301
  ident: CR19
  article-title: Regulated necrosis in kidney ischemia-reperfusion injury
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2019.02.009
  contributor:
    fullname: Cowan
– volume: 204
  start-page: 667
  year: 2021
  end-page: 681
  ident: CR20
  article-title: Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.202009-3442OC
  contributor:
    fullname: Lu
– volume: 54
  start-page: 133
  year: 2014
  end-page: 146
  ident: CR67
  article-title: Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.03.003
  contributor:
    fullname: Wang
– volume: 11
  year: 2020
  ident: CR34
  article-title: MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16887-1
  contributor:
    fullname: Samson
– volume: 22
  start-page: 1489
  year: 2014
  end-page: 1500
  ident: CR43
  article-title: A plug release mechanism for membrane permeation by MLKL
  publication-title: Structure
  doi: 10.1016/j.str.2014.07.014
  contributor:
    fullname: Su
– volume: 19
  start-page: 679
  year: 2022
  end-page: 682
  ident: CR60
  article-title: ColabFold: making protein folding accessible to all
  publication-title: Nat. Methods
  doi: 10.1038/s41592-022-01488-1
  contributor:
    fullname: Mirdita
– volume: 540
  start-page: 124
  year: 2016
  end-page: 128
  ident: CR16
  article-title: RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation
  publication-title: Nature
  doi: 10.1038/nature20558
  contributor:
    fullname: Lin
– volume: 25
  start-page: 885
  year: 2018
  end-page: 891
  ident: CR70
  article-title: MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron
  publication-title: J. Synchrotron Radiat.
  doi: 10.1107/S1600577518003120
  contributor:
    fullname: Aragao
– volume: 16
  start-page: 2219
  year: 2016
  end-page: 2230
  ident: CR3
  article-title: Necroptosis promotes clearance by inhibiting excessive inflammatory signaling
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.07.039
  contributor:
    fullname: Kitur
– volume: 540
  start-page: 129
  year: 2016
  end-page: 133
  ident: CR24
  article-title: RIPK1 inhibits ZBP1-driven necroptosis during development
  publication-title: Nature
  doi: 10.1038/nature20559
  contributor:
    fullname: Newton
– volume: 117
  start-page: 18771
  year: 2020
  end-page: 18779
  ident: CR2
  article-title: Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2001887117
  contributor:
    fullname: Fletcher-Etherington
– volume: 479
  start-page: 1621
  year: 2022
  end-page: 1651
  ident: CR15
  article-title: Cell death in skin function, inflammation, and disease
  publication-title: Biochem. J.
  doi: 10.1042/BCJ20210606
  contributor:
    fullname: Alqudah
– volume: 37
  start-page: e00497-16
  year: 2017
  ident: CR58
  article-title: The MLKL channel in necroptosis is an octamer formed by tetramers in a dyadic process
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00497-16
  contributor:
    fullname: Huang
– volume: 16
  start-page: e1008473
  year: 2020
  ident: CR8
  article-title: Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1008473
  contributor:
    fullname: Steain
– ident: CR7
– volume: 12
  year: 2021
  ident: CR29
  article-title: Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27032-x
  contributor:
    fullname: Meng
– volume: 21
  start-page: 493
  year: 2013
  end-page: 499
  ident: CR45
  article-title: Structural basis of RIP1 inhibition by necrostatins
  publication-title: Structure
  doi: 10.1016/j.str.2013.01.016
  contributor:
    fullname: Xie
– volume: 30
  start-page: 70
  year: 2021
  end-page: 82
  ident: CR77
  article-title: UCSF ChimeraX: Structure visualization for researchers, educators, and developers
  publication-title: Protein Sci.
  doi: 10.1002/pro.3943
  contributor:
    fullname: Pettersen
– ident: CR28
– volume: 148
  start-page: 213
  year: 2012
  end-page: 227
  ident: CR30
  article-title: Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
  contributor:
    fullname: Sun
– volume: 5
  start-page: 70
  year: 2013
  end-page: 78
  ident: CR54
  article-title: Structural insights into RIP3-mediated necroptotic signaling
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.08.044
  contributor:
    fullname: Xie
– volume: 30
  start-page: 27
  year: 2023
  ident: 42255_CR12
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-022-01042-8
  contributor:
    fullname: SM Bader
– volume: 479
  start-page: 1621
  year: 2022
  ident: 42255_CR15
  publication-title: Biochem. J.
  doi: 10.1042/BCJ20210606
  contributor:
    fullname: H Anderton
– volume: 66
  start-page: 133
  year: 2010
  ident: 42255_CR71
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909047374
  contributor:
    fullname: W Kabsch
– volume: 23
  start-page: 1185
  year: 2016
  ident: 42255_CR41
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2015.169
  contributor:
    fullname: MC Tanzer
– volume: 11
  year: 2020
  ident: 42255_CR10
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16819-z
  contributor:
    fullname: JM Hildebrand
– volume: 12
  year: 2021
  ident: 42255_CR33
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22400-z
  contributor:
    fullname: SE Garnish
– volume: 66
  start-page: 12
  year: 2010
  ident: 42255_CR76
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909042073
  contributor:
    fullname: VB Chen
– volume: 11
  start-page: e0165983
  year: 2016
  ident: 42255_CR55
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0165983
  contributor:
    fullname: B Ma
– volume: 11
  start-page: 609
  year: 2015
  ident: 42255_CR88
  publication-title: J. Chem. Theory Comput.
  doi: 10.1021/ct500864r
  contributor:
    fullname: MJ O’Meara
– volume: 540
  start-page: 129
  year: 2016
  ident: 42255_CR24
  publication-title: Nature
  doi: 10.1038/nature20559
  contributor:
    fullname: K Newton
– volume: 11
  start-page: 739
  year: 1998
  ident: 42255_CR86
  publication-title: Protein Eng.
  doi: 10.1093/protein/11.9.739
  contributor:
    fullname: IN Shindyalov
– volume: 117
  start-page: 33272
  year: 2020
  ident: 42255_CR63
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2017406117
  contributor:
    fullname: M Rubbelke
– volume: 540
  start-page: 124
  year: 2016
  ident: 42255_CR16
  publication-title: Nature
  doi: 10.1038/nature20558
  contributor:
    fullname: J Lin
– volume: 1
  start-page: 489
  year: 2000
  ident: 42255_CR21
  publication-title: Nat. Immunol.
  doi: 10.1038/82732
  contributor:
    fullname: N Holler
– volume: 64
  start-page: 15629
  year: 2021
  ident: 42255_CR65
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.1c00686
  contributor:
    fullname: M Rübbelke
– volume: 16
  start-page: 2219
  year: 2016
  ident: 42255_CR3
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.07.039
  contributor:
    fullname: K Kitur
– volume: 117
  start-page: 18771
  year: 2020
  ident: 42255_CR2
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2001887117
  contributor:
    fullname: A Fletcher-Etherington
– volume: 288
  start-page: 31268
  year: 2013
  ident: 42255_CR23
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.462341
  contributor:
    fullname: WJ Kaiser
– volume: 9
  year: 2018
  ident: 42255_CR40
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04714-7
  contributor:
    fullname: EJ Petrie
– volume: 18
  start-page: S193
  year: 2019
  ident: 42255_CR85
  publication-title: Mol. Cell. Proteomics
  doi: 10.1074/mcp.TIR118.001209
  contributor:
    fullname: DR Brademan
– volume: 25
  start-page: 1567
  year: 2018
  ident: 42255_CR37
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-018-0061-3
  contributor:
    fullname: KA Davies
– volume: 150
  start-page: 339
  year: 2012
  ident: 42255_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2012.06.019
  contributor:
    fullname: J Li
– volume: 21
  start-page: 493
  year: 2013
  ident: 42255_CR45
  publication-title: Structure
  doi: 10.1016/j.str.2013.01.016
  contributor:
    fullname: T Xie
– volume: 173
  start-page: 1244.e10
  year: 2018
  ident: 42255_CR44
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.032
  contributor:
    fullname: M Mompean
– volume: 28
  start-page: 2126
  year: 2021
  ident: 42255_CR89
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-021-00742-x
  contributor:
    fullname: AL Samson
– volume: 19
  start-page: 679
  year: 2022
  ident: 42255_CR60
  publication-title: Nat. Methods
  doi: 10.1038/s41592-022-01488-1
  contributor:
    fullname: M Mirdita
– volume: 40
  start-page: 658
  year: 2007
  ident: 42255_CR73
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S0021889807021206
  contributor:
    fullname: AJ McCoy
– volume: 26
  start-page: 517
  year: 2016
  ident: 42255_CR62
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.26
  contributor:
    fullname: B Xia
– volume: 103
  start-page: 17783
  year: 2006
  ident: 42255_CR53
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0607656103
  contributor:
    fullname: AP Kornev
– volume: 2
  start-page: 1896
  year: 2007
  ident: 42255_CR81
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.261
  contributor:
    fullname: J Rappsilber
– volume: 14
  start-page: eabc6178
  year: 2021
  ident: 42255_CR22
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.abc6178
  contributor:
    fullname: AL Samson
– volume: 12
  year: 2021
  ident: 42255_CR29
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27032-x
  contributor:
    fullname: Y Meng
– volume: 11
  year: 2020
  ident: 42255_CR34
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16887-1
  contributor:
    fullname: AL Samson
– volume: 28
  start-page: 861
  year: 2021
  ident: 42255_CR31
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-020-00722-7
  contributor:
    fullname: Y Meng
– volume: 69
  start-page: 1204
  year: 2013
  ident: 42255_CR72
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444913000061
  contributor:
    fullname: PR Evans
– volume: 667
  start-page: 183
  year: 2022
  ident: 42255_CR69
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2022.03.029
  contributor:
    fullname: C Fitzgibbon
– volume: 131
  start-page: 682
  year: 2007
  ident: 42255_CR27
  publication-title: Cell
  doi: 10.1016/j.cell.2007.10.037
  contributor:
    fullname: JE Vince
– volume: 12
  year: 2021
  ident: 42255_CR52
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-021-03859-6
  contributor:
    fullname: Y Zhang
– ident: 42255_CR9
  doi: 10.3390/biom11060803
– volume: 457
  start-page: 369
  year: 2014
  ident: 42255_CR42
  publication-title: Biochem. J.
  doi: 10.1042/BJ20131270
  contributor:
    fullname: JM Murphy
– volume: 39
  start-page: 443
  year: 2013
  ident: 42255_CR32
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
  contributor:
    fullname: JM Murphy
– volume: 15
  start-page: 2702
  year: 2020
  ident: 42255_CR56
  publication-title: ACS Chem. Biol.
  doi: 10.1021/acschembio.0c00482
  contributor:
    fullname: CL Pierotti
– ident: 42255_CR11
  doi: 10.1038/s41467-023-41724-6
– volume: 16
  start-page: e1008473
  year: 2020
  ident: 42255_CR8
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1008473
  contributor:
    fullname: M Steain
– volume: 13
  start-page: 565
  year: 2022
  ident: 42255_CR66
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-05009-y
  contributor:
    fullname: Y Meng
– volume: 29
  start-page: 1804
  year: 2022
  ident: 42255_CR50
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-022-00965-6
  contributor:
    fullname: A Sethi
– volume: 11
  year: 2020
  ident: 42255_CR36
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-16823-3
  contributor:
    fullname: KA Davies
– volume: 2
  start-page: 16258
  year: 2017
  ident: 42255_CR5
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2016.258
  contributor:
    fullname: JS Pearson
– volume: 148
  start-page: 213
  year: 2012
  ident: 42255_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
  contributor:
    fullname: L Sun
– volume: 44
  start-page: 53
  year: 2019
  ident: 42255_CR39
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2018.11.002
  contributor:
    fullname: EJ Petrie
– volume: 54
  start-page: 133
  year: 2014
  ident: 42255_CR67
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.03.003
  contributor:
    fullname: H Wang
– volume: 28
  start-page: 3309.e5
  year: 2019
  ident: 42255_CR6
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.08.055
  contributor:
    fullname: EJ Petrie
– volume: 61
  start-page: 589
  year: 2016
  ident: 42255_CR49
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.01.011
  contributor:
    fullname: G Quarato
– volume: 10
  start-page: 1794
  year: 2011
  ident: 42255_CR84
  publication-title: J. Proteome Res.
  doi: 10.1021/pr101065j
  contributor:
    fullname: J Cox
– volume: 30
  start-page: 70
  year: 2021
  ident: 42255_CR77
  publication-title: Protein Sci.
  doi: 10.1002/pro.3943
  contributor:
    fullname: EF Pettersen
– volume: 26
  start-page: 1367
  year: 2008
  ident: 42255_CR82
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1511
  contributor:
    fullname: J Cox
– volume: 5
  start-page: 70
  year: 2013
  ident: 42255_CR54
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.08.044
  contributor:
    fullname: T Xie
– ident: 42255_CR7
  doi: 10.1084/jem.20191259
– volume: 13
  start-page: 2864
  year: 2018
  ident: 42255_CR83
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-018-0068-8
  contributor:
    fullname: C Iacobucci
– volume: 74
  start-page: 3631
  year: 2017
  ident: 42255_CR18
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-017-2547-4
  contributor:
    fullname: T Muller
– volume: 117
  start-page: 8468
  year: 2020
  ident: 42255_CR59
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1919960117
  contributor:
    fullname: EJ Petrie
– volume: 33
  start-page: 162
  year: 2023
  ident: 42255_CR26
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2022.05.008
  contributor:
    fullname: CR Horne
– volume: 26
  start-page: 863.e7
  year: 2019
  ident: 42255_CR64
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.03.010
  contributor:
    fullname: DE McNamara
– volume: 96
  start-page: 291
  year: 2019
  ident: 42255_CR19
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2019.02.009
  contributor:
    fullname: A Pefanis
– volume: 281
  start-page: 13964
  year: 2006
  ident: 42255_CR90
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M601553200
  contributor:
    fullname: C Bossen
– volume: 19
  start-page: 300
  year: 2023
  ident: 42255_CR17
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-022-00658-w
  contributor:
    fullname: B Kolbrink
– volume: 54
  start-page: 343
  year: 2021
  ident: 42255_CR80
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S1600576720013412
  contributor:
    fullname: K Manalastas-Cantos
– volume: 513
  start-page: 90
  year: 2014
  ident: 42255_CR13
  publication-title: Nature
  doi: 10.1038/nature13608
  contributor:
    fullname: M Dannappel
– volume: 66
  start-page: 1153
  year: 2010
  ident: 42255_CR74
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444910026582
  contributor:
    fullname: PV Afonine
– volume: 37
  start-page: e00497-16
  year: 2017
  ident: 42255_CR58
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00497-16
  contributor:
    fullname: D Huang
– volume: 109
  start-page: 279
  year: 2014
  ident: 42255_CR14
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2013.403
  contributor:
    fullname: M Pierdomenico
– volume: 8
  start-page: e59004
  year: 2013
  ident: 42255_CR61
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0059004
  contributor:
    fullname: LG Nivon
– volume: 479
  start-page: 677
  year: 2022
  ident: 42255_CR35
  publication-title: Biochem. J.
  doi: 10.1042/BCJ20210604
  contributor:
    fullname: H Nakano
– volume: 204
  start-page: 667
  year: 2021
  ident: 42255_CR20
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.202009-3442OC
  contributor:
    fullname: Z Lu
– volume: 137
  start-page: 1112
  year: 2009
  ident: 42255_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2009.05.037
  contributor:
    fullname: YS Cho
– volume: 8
  start-page: e63090
  year: 2013
  ident: 42255_CR87
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0063090
  contributor:
    fullname: A Stein
– volume: 51
  start-page: 97
  year: 2018
  ident: 42255_CR79
  publication-title: J. Appl. Crystallogr.
  doi: 10.1107/S1600576717017101
  contributor:
    fullname: TM Ryan
– volume: 74
  start-page: 922.e6
  year: 2019
  ident: 42255_CR46
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2019.03.028
  contributor:
    fullname: J Ding
– volume: 25
  start-page: 885
  year: 2018
  ident: 42255_CR70
  publication-title: J. Synchrotron Radiat.
  doi: 10.1107/S1600577518003120
  contributor:
    fullname: D Aragao
– volume: 54
  start-page: 247.e7
  year: 2021
  ident: 42255_CR4
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.11.020
  contributor:
    fullname: Z Liu
– volume: 16
  start-page: 55
  year: 2014
  ident: 42255_CR47
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2883
  contributor:
    fullname: Z Cai
– volume: 111
  start-page: 15072
  year: 2014
  ident: 42255_CR38
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1408987111
  contributor:
    fullname: JM Hildebrand
– volume: 22
  start-page: 1489
  year: 2014
  ident: 42255_CR43
  publication-title: Structure
  doi: 10.1016/j.str.2014.07.014
  contributor:
    fullname: L Su
– volume: 7
  start-page: 971
  year: 2014
  ident: 42255_CR48
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.04.026
  contributor:
    fullname: Y Dondelinger
– volume: 114
  start-page: E7450
  year: 2017
  ident: 42255_CR68
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1707531114
  contributor:
    fullname: S Liu
– volume: 66
  start-page: 486
  year: 2010
  ident: 42255_CR75
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444910007493
  contributor:
    fullname: P Emsley
– ident: 42255_CR28
  doi: 10.1016/j.jbc.2023.104792
– volume: 44
  start-page: 300
  year: 2019
  ident: 42255_CR57
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2018.12.002
  contributor:
    fullname: G Gógl
– volume: 372
  start-page: 774
  year: 2007
  ident: 42255_CR51
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2007.05.022
  contributor:
    fullname: E Krissinel
– volume: 72
  start-page: 1254
  year: 2016
  ident: 42255_CR78
  publication-title: Acta Crystallogr. D Struct. Biol.
  doi: 10.1107/S2059798316017174
  contributor:
    fullname: N Kirby
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Snippet The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin...
Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut...
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Assembly
Cell death
Conformation
Dimerization
Electron microscopy
Humanities and Social Sciences
Inflammation
Kinases
Lung diseases
multidisciplinary
Necroptosis
Nucleation
Oligomerization
Phosphorylation
Science
Science (multidisciplinary)
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Title Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
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