Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer

• Published in: Bioactive materials Vol. 6; no. 1; pp. 273 - 284
• Main Authors: Liu, Jia, Deng, Yan, Fu, Daan, Yuan, Ye, Li, Qilin, Shi, Lin, Wang, Guobin, Wang, Zheng, Wang, Lin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Doxorubicin; Metal organic networks; Metastatic lung cancer; Pulmonary delivery system; Sericin microparticles; Pulmonary delivery system; Sericin microparticles; Doxorubicin; Metal organic networks; Metastatic lung cancer

Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer. However, systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects, due to the extremely low delivery efficacy and non-specificity of anticancer drugs. Herein, we report a ser...