Molecular profiling and gene expression analysis in cutaneous sarcoidosis: The role of interleukin-12, interleukin-23, and the T-helper 17 pathway

• Published in: Journal of the American Academy of Dermatology Vol. 66; no. 6; pp. 901 - 910.e2
• Main Authors: Judson, Marc A., Marchell, Richard M., Mascelli, MaryAnn, Piantone, Alexa, Barnathan, Elliot S., Petty, Kevin J., Chen, Dion, Fan, Hongtao, Grund, Heidi, Ma, Keying, Baribaud, Frédéric, Brodmerkel, Carrie
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.06.2012; Elsevier
• Subjects: Adult; Biological and medical sciences; Dermatology; Female; Gene Expression Profiling; Humans; interferon-gamma; interleukin-12; Interleukin-12 - physiology; interleukin-21; interleukin-23; lesional sarcoidosis; Male; Medical sciences; Microarray Analysis; Middle Aged; nonlesional sarcoidosis; Real-Time Polymerase Chain Reaction; Sarcoidosis - immunology; Sarcoidosis - physiopathology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Signal Transduction - physiology; Skin Diseases - physiopathology; STAT3 Transcription Factor - physiology; Th1 Cells - physiology; Th17 Cells - physiology; Up-Regulation - physiology; lesional sarcoidosis; CXCL; IL; nonlesional sarcoidosis; LS; interleukin-21; TNF; interleukin-12; interleukin-23; CS; IFN; STAT; TGF; NLS; Th; FDR; RRT; cDNA; interferon-gamma; PCR; lesional skin; real-time reverse transcription; signal transducer and activator of transcription; complementary DNA; T-helper; cutaneous sarcoidosis; interleukin; false discovery rate; polymerase chain reaction; chemokine (C-X-C motif) ligand; interferon; nonlesional skin; tumor necrosis factor; transforming growth factor; Interleukin 12; Skin; Sarcoidosis; Gene expression; Dermatology; Systemic disease

Cutaneous sarcoidosis (CS) skin provides relatively noninvasive access to granulomatous sarcoidosis tissue. We sought to explore the role of the T-helper (Th)1 and Th17 pathways in sarcoidosis. We used molecular profiling and gene expression analysis to analyze the Th1 and Th17 pathways and other im...