Age-related differences of cerebellar cortex and nuclei: MRI findings in healthy controls and its application to spinocerebellar ataxia (SCA6) patients

• Published in: NeuroImage (Orlando, Fla.) Vol. 270; p. 119950
• Main Authors: Jäschke, Dominik, Steiner, Katharina M., Chang, Dae-In, Claaßen, Jens, Uslar, Ellen, Thieme, Andreas, Gerwig, Marcus, Pfaffenrot, Viktor, Hulst, Thomas, Gussew, Alexander, Maderwald, Stefan, Göricke, Sophia L., Minnerop, Martina, Ladd, Mark E., Reichenbach, Jürgen R., Timmann, Dagmar, Deistung, Andreas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2023; Elsevier Limited; Elsevier
• Subjects: Adolescent; Adult; Age; Aged; Aging; Ataxia; Atrophy; Atrophy - pathology; Brain; Cerebellar Cortex - diagnostic imaging; Cerebellar Cortex - pathology; Cerebellar Nuclei - diagnostic imaging; Cerebellum; Cerebellum - pathology; Cortex; Dentate nucleus; Humans; Iron; Magnetic fields; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Middle Aged; MRI; Neuroimaging; Nuclei; Older people; Pathology; Quantitative susceptibility mapping; Spinocerebellar ataxia; Spinocerebellar ataxia type 6; Spinocerebellar Ataxias - diagnostic imaging; Spinocerebellar Ataxias - pathology; Statistical analysis; Substantia grisea; Susceptibility; Young Adult; Cerebellum; SCA6; MRI; Quantitative susceptibility mapping; R; MP-RAGE; BW; WM; Ataxia; FLAIR; Dentate nucleus; DNbulk; VBM; ppb; SWI; GM; HEIDI; QSM; Spinocerebellar ataxia type 6; TA; DCN; DNsil; TE; TI; SHARP; GRE; FA; T1w; TR

•Cerebellar nuclei are discernible on susceptibility maps (QSM) acquired at 3 Tesla in healthy subjects and patients with SCA6.•The QSM-based volume of the dentate nuclei in adults is independent of age.•Dentate nuclei are significantly atrophied in SCA6.•The amount of iron of the dentate nuclei is...