Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

• Published in: European journal of human genetics : EJHG Vol. 23; no. 10; pp. 1364 - 1369
• Main Authors: Jalkh, Nadine, Sahbatou, Mourad, Chouery, Eliane, Megarbane, André, Leutenegger, Anne-Louise, Serre, Jean-Louis
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2015
• Subjects: Asian Continental Ancestry Group - genetics; Children; Consanguinity; Consortia; Deoxyribonucleic acid; DNA; Family; Female; Genetic drift; Genetic testing; Genetics; Genome-Wide Association Study - methods; Genomes; Geography; Humans; Inbreeding; Inbreeding - methods; Lebanon; Male; Marriage; Parents & parenting; Polymorphism, Single Nucleotide - genetics; Population; Progeny; Regression Analysis; Religion; Religious orthodoxy; Single-nucleotide polymorphism; Lebanon; France; Beirut Lebanon

Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In consanguineous marriages, parents pass to their children autozygous segments known as homozygous by descent segments. In this study, single-nucleotid...