Genome-wide inbreeding estimation within Lebanese communities using SNP arrays

Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In consanguineous marriages, parents pass to their children autozygous segments known as homozygous by descent segments. In this study, single-nucleotid...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of human genetics : EJHG Vol. 23; no. 10; pp. 1364 - 1369
Main Authors Jalkh, Nadine, Sahbatou, Mourad, Chouery, Eliane, Megarbane, André, Leutenegger, Anne-Louise, Serre, Jean-Louis
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.10.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In consanguineous marriages, parents pass to their children autozygous segments known as homozygous by descent segments. In this study, single-nucleotide polymorphisms were analyzed in 165 unrelated Lebanese people from Greek Orthodox, Maronite, Shiite and Sunni communities. Runs of homozygosity, total inbreeding levels, remote consanguinity, and population admixture and structure were estimated. The inbreeding coefficient value was estimated to be 1.61% in offspring of unrelated parents over three generations and 8.33% in offspring of first cousins. From these values, remote consanguinity values, resulting from genetic drift or recurrent consanguineous unions, were estimated in offspring of unrelated and first-cousin parents to be 0.61 and 1.2%, respectively. This remote consanguinity value suggests that for any unrelated marriages in Lebanon, the mates could be related as third cousins or as second cousins once removed. Under the assumption that 25% of marriages occur between first cousins, the mean inbreeding value of 2.3% may explain the increased incidence of recessive disease in offspring. Our analysis reveals a common ancestral population in the four Lebanese communities we studied.
AbstractList Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In consanguineous marriages, parents pass to their children autozygous segments known as homozygous by descent segments. In this study, single-nucleotide polymorphisms were analyzed in 165 unrelated Lebanese people from Greek Orthodox, Maronite, Shiite and Sunni communities. Runs of homozygosity, total inbreeding levels, remote consanguinity, and population admixture and structure were estimated. The inbreeding coefficient value was estimated to be 1.61% in offspring of unrelated parents over three generations and 8.33% in offspring of first cousins. From these values, remote consanguinity values, resulting from genetic drift or recurrent consanguineous unions, were estimated in offspring of unrelated and first-cousin parents to be 0.61 and 1.2%, respectively. This remote consanguinity value suggests that for any unrelated marriages in Lebanon, the mates could be related as third cousins or as second cousins once removed. Under the assumption that 25% of marriages occur between first cousins, the mean inbreeding value of 2.3% may explain the increased incidence of recessive disease in offspring. Our analysis reveals a common ancestral population in the four Lebanese communities we studied.
Author Jalkh, Nadine
Chouery, Eliane
Leutenegger, Anne-Louise
Sahbatou, Mourad
Megarbane, André
Serre, Jean-Louis
Author_xml – sequence: 1
  givenname: Nadine
  surname: Jalkh
  fullname: Jalkh, Nadine
  organization: EA 2493 « pathologie cellulaire & génétique, de la conception à la naissance », Université de Versailles-Saint Quentin en Yvelines, Yvelines, France
– sequence: 2
  givenname: Mourad
  surname: Sahbatou
  fullname: Sahbatou, Mourad
  organization: Fondation Jean Dausset-CEPH, F-75010, Paris, France
– sequence: 3
  givenname: Eliane
  surname: Chouery
  fullname: Chouery, Eliane
  organization: Unité de Génétique Médicale et Laboratoire associé INSERM à l'Unité UMR_S910, Faculté de Médecine, Université Saint-Joseph, Beirut, Lebanon
– sequence: 4
  givenname: André
  surname: Megarbane
  fullname: Megarbane, André
  organization: Unité de Génétique Médicale et Laboratoire associé INSERM à l'Unité UMR_S910, Faculté de Médecine, Université Saint-Joseph, Beirut, Lebanon
– sequence: 5
  givenname: Anne-Louise
  surname: Leutenegger
  fullname: Leutenegger, Anne-Louise
– sequence: 6
  givenname: Jean-Louis
  surname: Serre
  fullname: Serre, Jean-Louis
  organization: EA 2493 « pathologie cellulaire & génétique, de la conception à la naissance », Université de Versailles-Saint Quentin en Yvelines, Yvelines, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25424710$$D View this record in MEDLINE/PubMed
BookMark eNqNkc1rFDEYh0NpsR967LUMePEy23xOMhdBirbCUgX1HJLMm90sO0lNZlr635tl21I9ecoLefjx_t7nFB3GFAGhc4IXBDN1CZv1akEx4QvKuwN0QrjsWsGZOqwzJqrlirBjdFrKBldKSvIGHVPBKZcEn6Dba4hphPYhDNCEaDPAEOKqgTKF0UwhxeYhTOsQmyVYE6FA49I4zjFMAUozlx384_Z7Y3I2j-UtOvJmW-Dd03uGfn35_PPqpl1-u_569WnZOkHU1AKl_YBBMeMNJ0w54Qy1rOt6Y6UgVnrDLOMeY4e9Hajyvjf90DlHLKXWszP0cZ97N9sRBgdxymar73JdOj_qZIL--yeGtV6le81FT7HkNeDDU0BOv-faVo-hONhua8c0F01kJ3qh6jH_AyWsF4wpVtH3_6CbNOdYL7GnZEeprFS7p1xOpWTwL3sTrHdS9U6q3knVVWrlL16XfaGfLbI_6GygqA
CitedBy_id crossref_primary_10_1038_nrg_2017_109
crossref_primary_10_1017_S0021932016000419
crossref_primary_10_1038_s41431_019_0361_1
crossref_primary_10_1186_s12881_018_0677_7
crossref_primary_10_1016_j_cub_2021_06_027
crossref_primary_10_1371_journal_pone_0196360
crossref_primary_10_1002_pd_5391
crossref_primary_10_1186_s13039_015_0130_y
Cites_doi 10.1038/gim.2013.108
10.1016/j.ajhg.2010.02.021
10.1126/science.296.5566.261b
10.1002/humu.20399
10.1073/pnas.0906079106
10.1093/nar/16.3.1215
10.1016/j.cll.2011.08.003
10.1111/j.1469-1809.2011.00693.x
10.1097/GIM.0b013e3181fbfcc4
10.1111/j.1469-1809.2006.00285.x
10.1086/378207
10.1016/j.ajhg.2008.08.007
10.1017/S0021932009003290
10.1038/nature06258
10.1159/000345125
10.1126/science.1153717
10.1371/journal.pone.0013996
10.1093/hmg/ddi493
10.1007/s12687-010-0002-4
10.1371/journal.pgen.1003316
10.1038/gim.2012.169
10.1038/ejhg.2010.205
10.1371/journal.pgen.0020190
10.1038/nature09298
ContentType Journal Article
Copyright Copyright Nature Publishing Group Oct 2015
Copyright © 2015 Macmillan Publishers Limited 2015 Macmillan Publishers Limited
Copyright_xml – notice: Copyright Nature Publishing Group Oct 2015
– notice: Copyright © 2015 Macmillan Publishers Limited 2015 Macmillan Publishers Limited
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88A
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOI 10.1038/ejhg.2014.246
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Databases
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest Central Student
Genetics Abstracts

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
Geography
Religion
DocumentTitleAlternate Genome wide inbreeding and SNP arrays
EISSN 1476-5438
EndPage 1369
ExternalDocumentID 3813043661
10_1038_ejhg_2014_246
25424710
Genre Journal Article
GeographicLocations Lebanon
France
Beirut Lebanon
GeographicLocations_xml – name: Lebanon
– name: Beirut Lebanon
– name: France
GroupedDBID ---
-Q-
0R~
29G
2WC
36B
39C
3V.
4.4
406
53G
5GY
70F
7X7
88A
88E
8AO
8FE
8FH
8FI
8FJ
8R4
8R5
AACDK
AANZL
AASML
AATNV
AAYOK
AAYZH
AAZLF
ABAKF
ABAWZ
ABDBF
ABJNI
ABLJU
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACKTT
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEFQL
AEJRE
AEMSY
AENEX
AESKC
AEVLU
AEXYK
AFBBN
AFKRA
AFSHS
AGAYW
AGEZK
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AOIJS
ASPBG
AVWKF
AXYYD
AZFZN
B0M
BAWUL
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CAG
CCPQU
CGR
COF
CS3
CUY
CVF
DIK
DNIVK
DPUIP
DU5
E3Z
EAD
EAP
EAS
EBC
EBD
EBLON
EBS
ECM
EE.
EHN
EIF
EIOEI
EJD
EMB
EMK
EMOBN
EPL
EPT
ESX
F5P
FDQFY
FEDTE
FERAY
FIGPU
FIZPM
FSGXE
FYUFA
GX1
HCIFZ
HMCUK
HVGLF
HYE
HZ~
IWAJR
JSO
JZLTJ
KQ8
LK8
M0L
M1P
M7P
NAO
NPM
NQJWS
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
Q2X
Q~Q
RIG
RKO
RNS
RNT
RNTTT
RPM
SNX
SNYQT
SOHCF
SRMVM
SV3
SWTZT
TAOOD
TBHMF
TDRGL
TR2
TUS
UKHRP
Y6R
~8M
AAYXX
CITATION
7XB
8FD
8FK
AZQEC
DWQXO
FR3
GNUQQ
K9.
P64
PQEST
PQUKI
PRINS
RC3
7X8
5PM
AAWBL
ID FETCH-LOGICAL-c518t-e229d0e83afa4138c5ca2b3669ab751b7fa3b34f00c0fbd28ff9a9d6cc1b22bf3
IEDL.DBID RPM
ISSN 1018-4813
IngestDate Tue Sep 17 20:48:37 EDT 2024
Fri Oct 25 11:03:11 EDT 2024
Fri Oct 25 08:13:52 EDT 2024
Wed Nov 06 08:41:20 EST 2024
Thu Nov 21 23:20:18 EST 2024
Tue Oct 15 23:49:32 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c518t-e229d0e83afa4138c5ca2b3669ab751b7fa3b34f00c0fbd28ff9a9d6cc1b22bf3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.nature.com/articles/ejhg2014246.pdf
PMID 25424710
PQID 1713976227
PQPubID 34182
PageCount 6
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4592074
proquest_miscellaneous_1765958476
proquest_miscellaneous_1713953383
proquest_journals_1713976227
crossref_primary_10_1038_ejhg_2014_246
pubmed_primary_25424710
PublicationCentury 2000
PublicationDate 2015-10-01
PublicationDateYYYYMMDD 2015-10-01
PublicationDate_xml – month: 10
  year: 2015
  text: 2015-10-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: Leiden
PublicationTitle European journal of human genetics : EJHG
PublicationTitleAlternate Eur J Hum Genet
PublicationYear 2015
Publisher Nature Publishing Group
Publisher_xml – name: Nature Publishing Group
References 23328890 - Genet Med. 2013 Feb;15(2):150-2
16955415 - Hum Mutat. 2006 Nov;27(11):1115-21
17194218 - PLoS Genet. 2006 Dec;2(12):e190
24008258 - Genet Med. 2013 Sep;15(9):753-4
21085596 - PLoS One. 2010;5(11):e13996
19175949 - J Biosoc Sci. 2009 Jul;41(4):505-17
20303063 - Am J Hum Genet. 2010 Apr 9;86(4):526-39
23182917 - Cytogenet Genome Res. 2013;139(2):80-7
23468648 - PLoS Genet. 2013;9(2):e1003316
20811451 - Nature. 2010 Sep 2;467(7311):52-8
16436455 - Hum Mol Genet. 2006 Mar 1;15(5):789-95
22188137 - Ann Hum Genet. 2012 Mar;76(2):159-67
22118739 - Clin Lab Med. 2011 Dec;31(4):595-613, ix
17943122 - Nature. 2007 Oct 18;449(7164):851-61
21555946 - Genet Med. 2011 Sep;13(9):841-7
21475666 - J Community Genet. 2010 Mar;1(1):37-40
3400644 - Am J Hum Genet. 1988 Aug;43(2):188-96
18760389 - Am J Hum Genet. 2008 Sep;83(3):359-72
17044859 - Ann Hum Genet. 2006 Nov;70(Pt 6):841-7
3241995 - Soc Biol. 1988 Fall-Winter;35(3-4):324-30
21364699 - Eur J Hum Genet. 2011 May;19(5):583-7
19805052 - Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1779-86
12900793 - Am J Hum Genet. 2003 Sep;73(3):516-23
21189493 - Genet Med. 2010 Dec;12(12):765-71
26376682 - Eur J Hum Genet. 2015 Oct;23(10):1434
3344216 - Nucleic Acids Res. 1988 Feb 11;16(3):1215
11954565 - Science. 2002 Apr 12;296(5566):261-2
18292342 - Science. 2008 Feb 22;319(5866):1100-4
M Kirin (BFejhg2014246_CR16) 2010; 5
BFejhg2014246_CR19
N Patterson (BFejhg2014246_CR20) 2006; 2
AH Bittles (BFejhg2014246_CR1) 2010; 107
AL Leutenegger (BFejhg2014246_CR6) 2011; 19
HM Cann (BFejhg2014246_CR11) 2002; 296
A Gialluisi (BFejhg2014246_CR27) 2012; 76
LP Ten Kate (BFejhg2014246_CR26) 2010; 1
LH Li (BFejhg2014246_CR21) 2006; 27
M Khlat (BFejhg2014246_CR23) 1988; 43
BFejhg2014246_CR4
SA Miller (BFejhg2014246_CR9) 1988; 16
International HapMap 3 Consortium (BFejhg2014246_CR10) 2010; 467
HM Kearney (BFejhg2014246_CR17) 2011; 31
J Gibson (BFejhg2014246_CR22) 2006; 15
NA Rosenberg (BFejhg2014246_CR13) 2006; 70
B Barbour (BFejhg2014246_CR25) 2009; 41
CW Rehder (BFejhg2014246_CR29) 2013; 15
H Hamamy (BFejhg2014246_CR3) 2011; 13
JS Bødker (BFejhg2014246_CR15) 2013; 139
JZ Li (BFejhg2014246_CR12) 2008; 319
M Khlat (BFejhg2014246_CR24) 1988; 35
FS Alkuraya (BFejhg2014246_CR2) 2010; 12
SR Browning (BFejhg2014246_CR7) 2010; 86
R McQuillan (BFejhg2014246_CR18) 2008; 83
M Haber (BFejhg2014246_CR8) 2013; 9
AL Leutenegger (BFejhg2014246_CR5) 2003; 73
KA Frazer (BFejhg2014246_CR14) 2007; 449
NA Rosenberg (BFejhg2014246_CR28) 2013; 15
References_xml – volume: 15
  start-page: 753
  year: 2013
  ident: BFejhg2014246_CR28
  publication-title: Genet Med
  doi: 10.1038/gim.2013.108
  contributor:
    fullname: NA Rosenberg
– volume: 86
  start-page: 526
  year: 2010
  ident: BFejhg2014246_CR7
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2010.02.021
  contributor:
    fullname: SR Browning
– volume: 296
  start-page: 261
  year: 2002
  ident: BFejhg2014246_CR11
  publication-title: Science
  doi: 10.1126/science.296.5566.261b
  contributor:
    fullname: HM Cann
– volume: 27
  start-page: 1115
  year: 2006
  ident: BFejhg2014246_CR21
  publication-title: Hum Mutat
  doi: 10.1002/humu.20399
  contributor:
    fullname: LH Li
– volume: 107
  start-page: 1779
  year: 2010
  ident: BFejhg2014246_CR1
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0906079106
  contributor:
    fullname: AH Bittles
– ident: BFejhg2014246_CR4
– volume: 16
  start-page: 1215
  year: 1988
  ident: BFejhg2014246_CR9
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/16.3.1215
  contributor:
    fullname: SA Miller
– volume: 31
  start-page: 595
  year: 2011
  ident: BFejhg2014246_CR17
  publication-title: Clin Lab Med
  doi: 10.1016/j.cll.2011.08.003
  contributor:
    fullname: HM Kearney
– volume: 76
  start-page: 159
  year: 2012
  ident: BFejhg2014246_CR27
  publication-title: Ann Hum Genet
  doi: 10.1111/j.1469-1809.2011.00693.x
  contributor:
    fullname: A Gialluisi
– volume: 12
  start-page: 765
  year: 2010
  ident: BFejhg2014246_CR2
  publication-title: Genet Med
  doi: 10.1097/GIM.0b013e3181fbfcc4
  contributor:
    fullname: FS Alkuraya
– volume: 70
  start-page: 841
  year: 2006
  ident: BFejhg2014246_CR13
  publication-title: Ann Hum Genet
  doi: 10.1111/j.1469-1809.2006.00285.x
  contributor:
    fullname: NA Rosenberg
– volume: 73
  start-page: 516
  year: 2003
  ident: BFejhg2014246_CR5
  publication-title: Am J Hum Genet
  doi: 10.1086/378207
  contributor:
    fullname: AL Leutenegger
– volume: 83
  start-page: 359
  year: 2008
  ident: BFejhg2014246_CR18
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2008.08.007
  contributor:
    fullname: R McQuillan
– volume: 41
  start-page: 505
  year: 2009
  ident: BFejhg2014246_CR25
  publication-title: J Biosoc Sci
  doi: 10.1017/S0021932009003290
  contributor:
    fullname: B Barbour
– ident: BFejhg2014246_CR19
– volume: 449
  start-page: 851
  year: 2007
  ident: BFejhg2014246_CR14
  publication-title: Nature
  doi: 10.1038/nature06258
  contributor:
    fullname: KA Frazer
– volume: 139
  start-page: 80
  year: 2013
  ident: BFejhg2014246_CR15
  publication-title: Cytogenet Genome Res
  doi: 10.1159/000345125
  contributor:
    fullname: JS Bødker
– volume: 319
  start-page: 1100
  year: 2008
  ident: BFejhg2014246_CR12
  publication-title: Science
  doi: 10.1126/science.1153717
  contributor:
    fullname: JZ Li
– volume: 5
  start-page: e13996
  year: 2010
  ident: BFejhg2014246_CR16
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0013996
  contributor:
    fullname: M Kirin
– volume: 15
  start-page: 789
  year: 2006
  ident: BFejhg2014246_CR22
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddi493
  contributor:
    fullname: J Gibson
– volume: 1
  start-page: 37
  year: 2010
  ident: BFejhg2014246_CR26
  publication-title: J Community Genet
  doi: 10.1007/s12687-010-0002-4
  contributor:
    fullname: LP Ten Kate
– volume: 9
  start-page: e1003316
  year: 2013
  ident: BFejhg2014246_CR8
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1003316
  contributor:
    fullname: M Haber
– volume: 15
  start-page: 150
  year: 2013
  ident: BFejhg2014246_CR29
  publication-title: Genet Med
  doi: 10.1038/gim.2012.169
  contributor:
    fullname: CW Rehder
– volume: 35
  start-page: 324
  year: 1988
  ident: BFejhg2014246_CR24
  publication-title: Soc Biol
  contributor:
    fullname: M Khlat
– volume: 19
  start-page: 583
  year: 2011
  ident: BFejhg2014246_CR6
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2010.205
  contributor:
    fullname: AL Leutenegger
– volume: 2
  start-page: 2074
  year: 2006
  ident: BFejhg2014246_CR20
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0020190
  contributor:
    fullname: N Patterson
– volume: 43
  start-page: 188
  year: 1988
  ident: BFejhg2014246_CR23
  publication-title: Am J Hum Genet
  contributor:
    fullname: M Khlat
– volume: 13
  start-page: 841
  year: 2011
  ident: BFejhg2014246_CR3
  publication-title: Genet Med Off J Am Coll Med Genet
  contributor:
    fullname: H Hamamy
– volume: 467
  start-page: 52
  year: 2010
  ident: BFejhg2014246_CR10
  publication-title: Nature
  doi: 10.1038/nature09298
  contributor:
    fullname: International HapMap 3 Consortium
SSID ssj0014771
Score 2.2468657
Snippet Consanguineous marriages have been widely practiced in several global communities with varying rates depending on religion, culture, and geography. In...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 1364
SubjectTerms Asian Continental Ancestry Group - genetics
Children
Consanguinity
Consortia
Deoxyribonucleic acid
DNA
Family
Female
Genetic drift
Genetic testing
Genetics
Genome-Wide Association Study - methods
Genomes
Geography
Humans
Inbreeding
Inbreeding - methods
Lebanon
Male
Marriage
Parents & parenting
Polymorphism, Single Nucleotide - genetics
Population
Progeny
Regression Analysis
Religion
Religious orthodoxy
Single-nucleotide polymorphism
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bSxwxFA7W0suLtLa2W21JofRtaiaXmeRJRLQidSm0wr4NuborOGt3V4r_vufMZLdewLdAwkzmnEy-cz-EfHFSOF1zj-lnoKCYVBUuWVGwYGSqVYrMYHLy6bA6PpMnIzXKBrd5Dqtc3ondRR2mHm3ku_AohE7O672rPwV2jULvam6h8YQ8LTlAOZznerRSuEpZ9woXK9FoVopcY5MJvRsvxucY2CW_cZR9b2PSA0HzfrzkLQA6ekU2suRI93tWvyZrsd0kz_pekjeb5EVuZz6G8fPT7DGH4TLm-A0Zfo_t9DIWfych0kkLunAHXBTrbPQJjBStspOW_ojOYmdK6vv0ESy6SjFC_pz-Gv6kdjazN_O35Ozo8PfBcZHbKRRelXpRRM5NYFELmyxAl_bKW-5EVRnralW6GnjkhEyMeZZc4DolY02ovC8d5y6JLbLeTtv4nlARRTIoHsCNIGVQOsTEeExV1MEm5Qfk65KgzVVfNaPpvN1CN0j5BinfAOUHZGdJ7ib_PPPmP6sH5PNqGo49-jLg86fXeY1C_fqxNVgsEeAXXvOu5-BqN6AXc8BlNiD1Hd6uFmDZ7bsz7WTcld-WynAQvD48vvVt8hI-UvVxfztkfTG7jh9Bflm4T90h_QdDHfCY
  priority: 102
  providerName: ProQuest
Title Genome-wide inbreeding estimation within Lebanese communities using SNP arrays
URI https://www.ncbi.nlm.nih.gov/pubmed/25424710
https://www.proquest.com/docview/1713976227
https://search.proquest.com/docview/1713953383
https://search.proquest.com/docview/1765958476
https://pubmed.ncbi.nlm.nih.gov/PMC4592074
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED9tQ6C9IBiwFUZlJMRbWscfSfy4TisTolEFTOpbZDv2FkTTqeuE9t9zzkdFQeKBpzzYUey7c353vi-A90Zwk6XMhvQzNFCUTyLjNY9oqYRPpXdUheTkWZ5cXolPC7nYA9nnwjRB-9ZUo_rHclRXN01s5e3Sjvs4sfF8di6kYgh9433YR_jtTfTOdSDS1sqicbgpi3lXWJPybOy-31yHaC4xYiL0LkLjiOHPme5i0l-K5p_xkr8B0PQZPO00R3LWrvA57Ln6CB63vSQfjuDJrPOSv4D8o6tXSxf9rEpHqhqN3gahSCio0WYqknD9WtXkszM6tKAkts0TCdVVSQiFvyZf8znR67V-uHsJV9OLb-eXUdc3IbIyzjaRY0yV1GVce40YlVlpNTM8SZQ2qYxNiswwXHhKLfWmZJn3SqsysTY2jBnPX8FBvardCRDuuFdBD8CjL0Qps9J5ypxPXFZqL-0APvSUK27b8hhF49bmWRGoXQRqF0jtAZz2dC26U3JXoHgEdYixdADvtsMo38Fpgdtf3XdzZDCk_zUnVEVEnMXPHLes2q6m5_EA0h0mbieE-tq7Iyh2TZ3tTsxe__ebb-AQ9y_b2L9TONis791b1GE2ZoiSu0iH8OhsOpnk-Jxc5PMvw0aSfwHY2PZu
link.rule.ids 230,314,727,780,784,885,12056,21388,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED-xTmy8IBgDCgOMhHjL5vgjiZ8QoI0CbTTBJu0t8udaJNLRdkL77_E1btlA2pslW4lz5_i-fwfwxghuqpJZLD-LBooKRWaC5hl1SoRSBk8VFieP6mJwKr6cybPkcJuntMrVnbi8qN3Uoo_8ID4KRSdj5buLXxl2jcLoamqhsQGbiJwue7D54bA-_raOI4iyM7lojm6znCeUTcqrA_9jfI6pXWKfofZ7XSr9p2r-mzF5TQQdPYD7SXck7ztmP4Q7vt2Bu103yasd2E4NzcdxvDVKMfM4XGUdP4L6k2-nP332e-I8mbTRGl6KLoJIG10JI0G_7KQlQ2809qYktisgQdhVgjny5-R7fUz0bKav5rtwenR48nGQpYYKmZV5tcg8Y8pRX3EddBRelZVWM8OLQmlTytyUkUuGi0CppcE4VoWgtHKFtblhzAT-GHrttPVPgXDPg0IFId4JQjhZOR8o86HwldNB2j68XRG0uehwM5plvJtXDVK-Qco3kfJ92FuRu0m_z7z5y-w-vF5Px4OP0Yz4-dPLtEaihX3bGoRLjAI4vuZJx8H1bqJlzKJkpn0ob_B2vQCBt2_OtJPxEoBbSMWi6vXs9q2_gu3ByWjYDD_XX5_DvfjBsssC3IPeYnbpX0RtZmFepiP7B9Pn9O4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJzZeJhgfKxtgJMRbmGPHSfyE-FgZsEUVMGlvke3YayctHW0ntP-eu8YtG0h7s2Qrse9s353vd3cAr20mbVkIR-FnaKDokCc2GJnwRmehUMFzTcHJR1V-cJx9PVEnEf80i7DK5Z24uKibiaM38j38FIlOgaZ6iLCI4afBu4tfCVWQIk9rLKdxF9ZQKnLRg7UP-9Xw-8qnkBWd-cVTekJLZcy4yWW5589GpwTzyt4K0oSvS6j_1M5_0ZPXxNHgAWxGPZK97xj_EO74dgvudZUlr7ZgIxY3H2F7_Sj6z7G5RCA_guqzbyfnPvk9bjwbt2gZL8QYo6wbXTgjozfaccsOvTVUp5K5LpiEUrAywsufsh_VkJnp1FzNHsPxYP_nx4MkFldInErLeeKF0A33pTTBoCArnXJGWJnn2thCpbZAjlmZBc4dD7YRZQja6CZ3LrVC2CCfQK-dtH4bmPQyaFIW8H7IskaVjQ9c-JD7sjFBuT68WRK0vuhyaNQL37csa6J8TZSvkfJ92F2Su45HaVb_ZXwfXq268RCQZwOXP7mMYxRZ27eNodSJKIzxN087Dq5mg1ayQCnN-1Dc4O1qACXhvtnTjkeLZNyZ0gLVsGe3T_0lrONurQ-_VN924D6uV3WAwF3ozaeX_jkqNnP7Iu7YPxwN-Rs
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genome-wide+inbreeding+estimation+within+Lebanese+communities+using+SNP+arrays&rft.jtitle=European+journal+of+human+genetics+%3A+EJHG&rft.au=Jalkh%2C+Nadine&rft.au=Sahbatou%2C+Mourad&rft.au=Chouery%2C+Eliane&rft.au=Megarbane%2C+Andre&rft.date=2015-10-01&rft.issn=1018-4813&rft.volume=23&rft.issue=10&rft.spage=1364&rft.epage=1369&rft_id=info:doi/10.1038%2Fejhg.2014.246&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1018-4813&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1018-4813&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1018-4813&client=summon