Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

• Published in: Nature communications Vol. 14; no. 1; p. 7048
• Main Authors: Nakai, Kazuki, Lin, Hancheng, Yamano, Shotaro, Tanaka, Shinya, Kitamoto, Sho, Saitoh, Hitoshi, Sakuma, Kenta, Kurauchi, Junpei, Akter, Eilma, Konno, Masamitsu, Ishibashi, Kojiro, Kamata, Ryo, Ohashi, Akihiro, Koseki, Jun, Takahashi, Hirotaka, Yokoyama, Hideshi, Shiraki, Yukihiro, Enomoto, Atsushi, Abe, Sohei, Hayakawa, Yoku, Ushiku, Tetsuo, Mutoh, Michihiro, Fujita, Yasuyuki, Kon, Shunsuke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/70; 631/80; 631/80/304; 64; 64/60; Basal lamina; Carcinogenesis; Carcinogens; Cell activation; Cells; Colorectal carcinoma; Competition; Competitive advantage; Epithelial cells; Epithelium; Extrusion; Humanities and Social Sciences; Intestine; Invasiveness; multidisciplinary; NF-κB protein; Science; Science (multidisciplinary); Transformed cells; Wnt protein

Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into the apical lumen via cell competition. However, the internal or external factors that compromise cell competition and provoke carcinogenesis remain elusive. In this study, we examine the e...