Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification

• Published in: Molecular neurobiology Vol. 56; no. 5; pp. 3591 - 3602
• Main Authors: Rama, Sylvain, Boumedine-Guignon, Norah, Sangiardi, Marion, Youssouf, Fahamoe, Maulet, Yves, Lévêque, Christian, Belghazi, Maya, Seagar, Michael, Debanne, Dominique, El Far, Oussama
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2019; Springer Nature B.V; Humana Press
• Subjects: Acidification; Adenosine triphosphatase; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cellular Biology; Chromophores; H+-transporting ATPase; Inactivation; Life Sciences; Neurobiology; Neurology; Neurosciences; Neurotransmission; Neurotransmitter release; Neurotransmitters; Proteins; Pyramidal cells; SNAP receptors; Synaptic vesicles; GeneGun; V-ATPase; Hippocampal organotypic slice culture; Neurons; Neurotransmission; Chromophore-assisted light inactivation (CALI); GeneGun Keywords V-ATPase

Synaptic vesicle proton V-ATPase is an essential component in synaptic vesicle function. Active acidification of synaptic vesicles, triggered by the V-ATPase, is necessary for neurotransmitter storage. Independently from its proton transport activity, an additional important function of the membrane...