Excitatory purinergic and cholinergic expression changed in a partial bladder outlet obstruction-induced overactive bladder rat model

• Published in: Scientific reports Vol. 13; no. 1; pp. 18395 - 13
• Main Authors: Huang, Jingyi, Li, Hongliang, Zhang, Yao, Liu, Jiaye, Cao, Hongying, Long, Yongling
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4025; 692/420; 692/617; Acetyltransferase; Bladder; Carbachol; Choline O-acetyltransferase; Gene expression; Humanities and Social Sciences; mRNA; multidisciplinary; Muscle contraction; Muscles; Protein expression; Science; Science (multidisciplinary); Smooth muscle; Surgery

Overactive bladder (OAB) is a common, long-term symptom complex with a high prevalence in women worldwide. OAB has caused a social burden, and effective treatments are urgently needed. However, the pathogenesis of OAB has yet to be elucidated. Model rats underwent bladder outlet obstruction surgery....