Highly Potent Metallopeptide Analogues of Luteinizing Hormone-Releasing Hormone

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 86; no. 16; pp. 6313 - 6317
• Main Authors: Bajusz, S., Janaky, T., Csernus, V. J., Bokser, L., Fekete, M., Srkalovic, G., Redding, T. W., Schally, A. V.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.08.1989; National Acad Sciences
• Subjects: 550201 - Biochemistry- Tracer Techniques; Agonists; Amino Acid Sequence; AMINO ACIDS; ANIMAL CELLS; Animals; Antineoplastic agents; BASIC BIOLOGICAL SCIENCES; BETA DECAY RADIOISOTOPES; Biological and medical sciences; BODY; Breast cancer; Breast Neoplasms - metabolism; CARBOXYLIC ACIDS; Cell growth; Cell Membrane - metabolism; Cell membranes; CHEMICAL REACTIONS; CHROMATOGRAPHY; Chromatography, High Pressure Liquid; Cisplatin - analogs & derivatives; Cisplatin - chemical synthesis; Cisplatin - pharmacology; Copper - pharmacology; CROSS-LINKING; DAYS LIVING RADIOISOTOPES; Diamino amino acids; Dipeptides - chemical synthesis; ELECTRON CAPTURE RADIOISOTOPES; Female; General aspects; GLANDS; Gonadotropin-Releasing Hormone - analogs & derivatives; Gonadotropin-Releasing Hormone - chemical synthesis; Gonadotropin-Releasing Hormone - metabolism; Gonadotropin-Releasing Hormone - pharmacology; GONADOTROPINS; HORMONES; Humans; In Vitro Techniques; INTERMEDIATE MASS NUCLEI; IODINE 125; IODINE ISOTOPES; ISOTOPES; LH; LIBERINS; LIQUID COLUMN CHROMATOGRAPHY; Luteinization; Luteinizing Hormone - metabolism; LYSINE; MAMMARY GLANDS; Medical sciences; MEMBRANE PROTEINS; METALLOPROTEINS; Molecular Sequence Data; MOLECULAR STRUCTURE; Nickel; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; Organometallic Compounds - chemical synthesis; Organometallic Compounds - pharmacology; ORGANS; Ovulation - drug effects; PEPTIDE HORMONES; Pharmacology. Drug treatments; Pituitary Gland - drug effects; Pituitary Gland - metabolism; PITUITARY HORMONES; PLATINUM COMPOUNDS; POLYMERIZATION; PROTEINS; RADIOISOTOPES; Rats; RECEPTORS; Receptors, LHRH - metabolism; SEPARATION PROCESSES; Structure-Activity Relationship; TRANSITION ELEMENT COMPOUNDS; Tumor cell line; TUMOR CELLS; Tumors; Antineoplastic agent; Human; Hypothalamic hormone; Analog; Animal; Gonadotropin RH; Affinity; Drug targeting; Tumor cell; Metal Complexes; Platinum II Complexes

Metal complexes related to the cytotoxic complexes cisplatin [cis-diamminedichloroplatinum(II)] and trans-bis(salicylaldoximato)copper(II) were incorporated into suitably modified luteinizing hormone-releasing hormone (LH-RH) analogues containing D-lysine at position 6. Some of the metallopeptides t...