RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways

• Published in: Nature communications Vol. 14; no. 1; pp. 6635 - 19
• Main Authors: Lin, Zhibin, Yang, Peijun, Hu, Yufeng, Xu, Hao, Duan, Juanli, He, Fei, Dou, Kefeng, Wang, Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 14/19; 38/77; 692/4017; 692/4020/4021/1607/2751; 692/699/2743; 96/1; 96/21; Cell injury; Degradation; Fatty liver; Fibrosis; Hepatocytes; Humanities and Social Sciences; Immunoprecipitation; In vivo methods and tests; Inflammation; Innate immunity; Insulin resistance; Lipids; Liver; Liver diseases; Mass spectrometry; Mass spectroscopy; multidisciplinary; Phenotypes; Proteasomes; Proteins; RING finger proteins; Science; Science (multidisciplinary); Signal transduction; Steatosis; Stimulators; Transcriptomes; Ubiquitin-protein ligase; Ubiquitination

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Recent studies show that innate immunity-related signaling pathways fuel NAFLD progression. This study aims to identify potent regulators of innate immunity during NAFLD progression. To this end, a phenotype-based...