Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors - Chen, Evan M.; Quijano, Amanda R.; Seo, Young-Eun; Jackson, Christopher; Josowitz, Alexander D.; Noorbakhsh, Seth; Merlettini, Andrea; Sundaram, Ranjini K.; Focarete, Maria Letizia; Jiang, Zhaozhong; Bindra, Ranjit S.; Saltzman, W. Mark (Biomaterials, 2018)
Keywords: Animals; Biocompatible Materials - chemistry; biodegradability; blood-brain barrier; brain; brain neoplasms; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; composite polymers; Convection; Convection-enhanced delivery; Drug Delivery Systems; Drug Liberation; drugs; fractionation; Hydrodynamics; hydrophilicity; hydrophobicity; Intracranial; Isoxazoles - pharmacology; Male; metabolism; nanocarriers; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; PEG; Polyesters - chemical synthesis; Polyesters - chemistry; polyethylene glycol; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Pyrazines - pharmacology; Radiation-Sensitizing Agents - pharmacology; Radiosensitizer; radiotherapy; rats; Rats, Inbred F344; Xenograft Model Antitumor Assays; Nanoparticles; Intracranial; Radiosensitizer; PEG; Convection-enhanced delivery