Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity

Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero exposure of the fetus to malaria antigens may negatively impact the developing immune system and result in tolerance to malaria. Here, we rev...

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Published in	Trends in molecular medicine Vol. 22; no. 10; pp. 877 - 888
Main Authors	Odorizzi, Pamela M, Feeney, Margaret E
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.10.2016
Subjects	Female fetal immune system fetal tolerance Fetus - cytology Fetus - immunology Fetus - pathology Humans Immune Tolerance Immunity Immunity, Cellular Immunity, Innate Infectious Disease Transmission, Vertical Malaria - complications Malaria - epidemiology Malaria - immunology Malaria - pathology Pathology placental malaria Pregnancy Pregnancy Complications, Parasitic - epidemiology Pregnancy Complications, Parasitic - immunology Pregnancy Complications, Parasitic - pathology pregnancy-associated malaria Prenatal Exposure Delayed Effects - epidemiology Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - pathology T-Lymphocytes - immunology fetal immune system fetal tolerance placental malaria pregnancy-associated malaria
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Abstract	Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero exposure of the fetus to malaria antigens may negatively impact the developing immune system and result in tolerance to malaria. Here, we review our current knowledge of fetal immunity to malaria, focusing on the dynamic interactions between maternal malaria infection, placental development, and the fetal immune system. A better understanding of the long-term impact of in utero malaria exposure on the development of natural immunity to malaria, immune responses to other childhood pathogens, and vaccine immunogenicity is urgently needed. This may guide the implementation of novel chemoprevention strategies during pregnancy and facilitate the push toward malaria vaccines.
AbstractList	Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero exposure of the fetus to malaria antigens may negatively impact the developing immune system and result in tolerance to malaria. Here, we review our current knowledge of fetal immunity to malaria, focusing on the dynamic interactions between maternal malaria infection, placental development, and the fetal immune system. A better understanding of the long-term impact of in utero malaria exposure on the development of natural immunity to malaria, immune responses to other childhood pathogens, and vaccine immunogenicity is urgently needed. This may guide the implementation of novel chemoprevention strategies during pregnancy and facilitate the push toward malaria vaccines. Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero exposure of the fetus to malaria antigens may negatively impact the developing immune system and result in tolerance to malaria. Here, we review our current knowledge of fetal immunity to malaria, focusing on the dynamic interactions between maternal malaria infection, placental development, and the fetal immune system. A better understanding of the long-term impact of in utero malaria exposure on the development of natural immunity to malaria, immune responses to other childhood pathogens, and vaccine immunogenicity is urgently needed. This may guide the implementation of novel chemoprevention strategies during pregnancy and facilitate the push toward malaria vaccines. Fetal T cells are uniquely predisposed towards tolerance, including regulatory T cell differentiation and attenuated inflammatory cytokine production. Recent evidence suggests that robust effector T cell responses can be mounted during fetal life. Although the fetal microenvironment has traditionally been regarded as sterile, microbes and pathogens can disrupt the maternal–fetal interface and impact fetal development and immunity. Pregnancy-associated malaria, including placental malaria, may lead to priming of regulatory and effector T cell responses in utero. Novel interventions, including artemisinin-based chemoprevention, may enable prevention of malaria during pregnancy. Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero exposure of the fetus to malaria antigens may negatively impact the developing immune system and result in tolerance to malaria. Here, we review our current knowledge of fetal immunity to malaria, focusing on the dynamic interactions between maternal malaria infection, placental development and the fetal immune system. A better understanding of the long-term impact of in utero malaria exposure on the development of natural immunity to malaria, immune responses to other childhood pathogens, and vaccine immunogenicity is urgently needed. This may guide the implementation of novel chemoprevention strategies during pregnancy and facilitate the push towards malaria vaccines.
Author	Feeney, Margaret E Odorizzi, Pamela M
AuthorAffiliation	2 Department of Pediatrics, University of California, San Francisco, USA 1 Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
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Author_xml	– sequence: 1 fullname: Odorizzi, Pamela M – sequence: 2 fullname: Feeney, Margaret E
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27614925$$D View this record in MEDLINE/PubMed
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Snippet	Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero... Pregnancy-associated malaria, including placental malaria, causes significant morbidity and mortality worldwide. Recently, it has been suggested that in utero...
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SubjectTerms	Female fetal immune system fetal tolerance Fetus - cytology Fetus - immunology Fetus - pathology Humans Immune Tolerance Immunity Immunity, Cellular Immunity, Innate Infectious Disease Transmission, Vertical Malaria - complications Malaria - epidemiology Malaria - immunology Malaria - pathology Pathology placental malaria Pregnancy Pregnancy Complications, Parasitic - epidemiology Pregnancy Complications, Parasitic - immunology Pregnancy Complications, Parasitic - pathology pregnancy-associated malaria Prenatal Exposure Delayed Effects - epidemiology Prenatal Exposure Delayed Effects - immunology Prenatal Exposure Delayed Effects - pathology T-Lymphocytes - immunology
Title	Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity
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