Transcriptional Regulation of Osteoblasts

• Published in: Cells, tissues, organs Vol. 189; no. 1-4; pp. 144 - 152
• Main Authors: Franceschi, Renny T., Ge, Chunxi, Xiao, Guozhi, Roca, Hernan, Jiang, Di
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2009
• Subjects: Animals; Bone and Bones - abnormalities; Bone and Bones - metabolism; Bone Development; Cell Differentiation; Cell Line; Cell Lineage; Chromatin - metabolism; Core Binding Factor Alpha 1 Subunit - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Expression Regulation; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Integrin-Binding Sialoprotein; MAP Kinase Signaling System; Mice; Mice, Transgenic; Organ Specificity; Osteoblasts - cytology; Osteoblasts - enzymology; Osteoblasts - metabolism; Protein Binding; Protein Processing, Post-Translational; Sialoglycoproteins - metabolism; Transcription, Genetic; Transgenes; Development; Osteoblast; Bone; Transcription
• ISBN: 9783805586245; 3805586248
• ISSN: 1422-6405; 1422-6421; 1422-6421
• DOI: 10.1159/000151747

The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate decisions controlled by a hierarchy of transcription factors. These include RUNX2, Osterix (OSX), ATF4 and a large number of nuclear coregulators. During bone development, initial RUNX2 expression coincides...