On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging

• Published in: Lab on a chip Vol. 16; no. 4; pp. 679 - 687
• Main Authors: Peyman, Sally A, McLaughlan, James R, Abou-Saleh, Radwa H, Marston, Gemma, Johnson, Benjamin R. G, Freear, Steven, Coletta, P. Louise, Markham, Alexander F, Evans, Stephen D
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Animals; Aorta - diagnostic imaging; Bubbles; Contrast agents; Contrast Media - chemistry; Drug Stability; Fluorocarbons - chemistry; Imaging; Lab-On-A-Chip Devices; Lipids - chemistry; Mice; Microfluidics; Nanoparticles; Nanostructure; Particle Size; Resonant frequencies; Signal-To-Noise Ratio; Ultrasonography - instrumentation; Ultrasonography - methods; Ultrasound

Micron-sized lipid-stabilised bubbles of heavy gas have been utilised as contrast agents for diagnostic ultrasound (US) imaging for many years. Typically bubbles between 1 and 8 μm in diameter are produced to enhance imaging in US by scattering sound waves more efficiently than surrounding tissue. A...