Cooler: scalable storage for Hi-C data and other genomically labeled arrays

• Published in: Bioinformatics Vol. 36; no. 1; pp. 311 - 316
• Main Authors: Abdennur, Nezar, Mirny, Leonid A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2020
• Subjects: Algorithms; Genomics - methods; Information Storage and Retrieval; Metadata; Original Papers; Software

Abstract Motivation Most existing coverage-based (epi)genomic datasets are one-dimensional, but newer technologies probing interactions (physical, genetic, etc.) produce quantitative maps with two-dimensional genomic coordinate systems. Storage and computational costs mount sharply with data resolut...