Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils - Thimmulappa, Rajesh K; Fuchs, Ralph J; Malhotra, Deepti; Scollick, Catherine; Traore, Kassim; Bream, Jay H; Trush, Michael A; Liby, Karen T; Sporn, Michael B; Kensler, Thomas W; Biswal, Shyam (Antioxidants & redox signaling, 2007)
Keywords: Cytokines - metabolism; Drug Evaluation, Preclinical; Gene Expression Regulation - drug effects; Humans; Imidazoles - pharmacology; Inflammation - chemically induced; Inflammation - genetics; Inflammation - immunology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Lipopolysaccharides - toxicity; Neutrophils - drug effects; Neutrophils - immunology; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - physiology; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - pharmacology; Reactive Oxygen Species - metabolism; Receptors, Formyl Peptide - metabolism; RNA, Messenger - metabolism; Time Factors; Tumor Necrosis Factor-alpha - metabolism