Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study

• Published in: Alzheimer's research & therapy Vol. 17; no. 1; pp. 17 - 13
• Main Authors: Gao, Yian, Liang, Changhu, Zhang, Qihao, Zhuang, Hangwei, Sui, Chaofan, Zhang, Nan, Feng, Mengmeng, Xin, Haotian, Guo, Lingfei, Wang, Yi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2025; BioMed Central; BMC
• Subjects: Aged; Blood circulation disorders; Brain; Brain - diagnostic imaging; Brain - metabolism; Cerebral small vessel disease; Cerebral Small Vessel Diseases - complications; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - metabolism; Cerebral Small Vessel Diseases - psychology; Cognition disorders; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - etiology; Cognitive Dysfunction - metabolism; Cognitive impairment; Complications and side effects; Female; Gray Matter - diagnostic imaging; Gray Matter - metabolism; Gray Matter - pathology; Health aspects; Humans; Iron - metabolism; Iron in the body; Magnetic Resonance Imaging - methods; Male; Medical research; Medicine, Experimental; Middle Aged; Neuropsychological Tests; Physiological aspects; Quantitative susceptibility mapping; Risk factors; Stroop color-word test; Total CSVD score; China; Quantitative susceptibility mapping; Total CSVD score; Cerebral small vessel disease; Stroop color-word test; Cognitive impairment

Quantitative susceptibility mapping (QSM) can study the susceptibility values of brain tissue which allows for noninvasive examination of local brain iron levels in both normal and pathological conditions. Our study compares brain iron deposition in gray matter (GM) nuclei between cerebral small ves...