Pathogenesis of Influenza A(H7N9) Virus in Aged Nonhuman Primates

• Published in: The Journal of infectious diseases Vol. 222; no. 7; pp. 1155 - 1164
• Main Authors: Fukuyama, Satoshi, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Nakajima, Noriko, Gregg, Robert W, Katsura, Hiroaki, Tomita, Yuriko, Maemura, Tadashi, da Silva Lopes, Tiago Jose, Watanabe, Tokiko, Shoemaker, Jason E, Hasegawa, Hideki, Yamayoshi, Seiya, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.09.2020
• Subjects: Aging; Animals; Avian flu; Chemokines; Cytokines; Cytokines - immunology; Disease Models, Animal; Female; Geriatrics; Immune response; Infections; Inflammation; Influenza; Influenza A; Influenza A Virus, H7N9 Subtype; Lung - immunology; Lung - pathology; Lung - virology; Lungs; Macaca fascicularis; Major and Brief Reports; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - virology; Pathogenicity; Virus Replication; influenza; Aging; nonhuman primate; dysregulated immunity; immune senescence

Abstract The avian influenza A(H7N9) virus has caused high mortality rates in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In the current study, we used nonhuman primates to evaluate the effect of aging on the pathogenicity of A(H7N9) virus. We ob...