Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine

• Published in: The Journal of neuroscience Vol. 43; no. 26; pp. 4884 - 4895
• Main Authors: Kantonen, Oskari, Laaksonen, Lauri, Alkire, Michael, Scheinin, Annalotta, Långsjö, Jaakko, Kallionpää, Roosa E., Kaisti, Kaike, Radek, Linda, Johansson, Jarkko, Laitio, Timo, Maksimow, Anu, Scheinin, Joonas, Nyman, Mikko, Scheinin, Mika, Solin, Olof, Vahlberg, Tero, Revonsuo, Antti, Valli, Katja, Scheinin, Harry
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 28.06.2023
• Subjects: Amino acid sequence; Anesthesia; Anesthetics; Anesthetics, Inhalation - pharmacology; Anesthetics, Intravenous; connected; Consciousness; Consciousness and Cognitive Neuroscience; Dexmedetomidine - pharmacology; disconnected; Humans; Ketamine; Ketamine - pharmacology; Kognitiv neurovetenskap och filosofi; Male; Metabolic rate; Metabolism; neuroimaging; Placebos; Positron emission; Positron emission tomography; Propofol; Propofol - pharmacology; Sevoflurane; Sevoflurane - pharmacology; Thalamus; Vaporizers; connected; Anesthesia; disconnected; consciousness; positron emission tomography; neuroimaging

Establishing the neural mechanisms responsible for the altered global states of consciousness during anesthesia and dissociating these from other drug-related effects remains a challenge in consciousness research. We investigated differences in brain activity between connectedness and disconnectedne...