Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53

• Published in: Cell death & disease Vol. 14; no. 10; pp. 710 - 12
• Main Authors: Zhong, Dandan, Quan, Lingling, Hao, Chang, Chen, Jingshuo, Qiao, Ranran, Lin, Tengfei, Ying, Changjiang, Sun, Dong, Jia, Zhanjun, Sun, Ying
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.10.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/89; 14/19; 14/28; 45/90; 45/91; 631/80/82; 692/699/1585/4; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell injury; Cisplatin; Ferroptosis; Heme; Immunology; Ischemia; Kidneys; Life Sciences; Morbidity; p53 Protein; Prostaglandin E; Prostaglandin E2; Renal function; Reperfusion

Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2 (mPGES-2) is a PGE 2 synthase but can metabolize PGH 2 to malondialdehyde by forming a complex with heme. However, the role and mechanism of action of mPG...