Upregulation of Intercellular Adhesion Molecule 1 and Proinflammatory Cytokines by the Major Surface Proteins of Treponema maltophilum and Treponema lecithinolyticum, the Phylogenetic Group IV Oral Spirochetes Associated with Periodontitis and Endodontic Infections

• Published in: Infection and Immunity Vol. 73; no. 1; pp. 268 - 276
• Main Authors: Lee, Sung-Hoon, Kim, Kack-Kyun, Choi, Bong-Kyu
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 2005
• Subjects: Bacteriology; Biological and medical sciences; Cell Line; Cloning, Molecular; Cytokines - biosynthesis; Cytokines - genetics; Endodontics; Escherichia coli; Fundamental and applied biological sciences. Psychology; Host Response and Inflammation; Humans; Intercellular Adhesion Molecule-1 - biosynthesis; Intercellular Adhesion Molecule-1 - genetics; Interleukin 1 Receptor Antagonist Protein; Membrane Proteins - genetics; Membrane Proteins - physiology; Microbiology; Miscellaneous; NF-kappa B - physiology; Periodontitis - microbiology; Phylogeny; RNA, Messenger - analysis; Sialoglycoproteins - pharmacology; Treponema - classification; Treponema - immunology; Treponema lecithinolyticum; Treponema maltophilum; Up-Regulation; Periodontal disease; Spirochaetales; Microbiology; Periodontitis; Intercellular adhesion molecule 1; Stomatology; Cytokine; Bacteria; Phylogeny; Treponemataceae; Immunity; Treponema

Treponema maltophilum and Treponema lecithinolyticum belong to the group IV oral spirochetes and are associated with endodontic infections, as well as periodontitis. Recently, the genes encoding the major surface proteins (Msps) of these bacteria (MspA and MspTL, respectively) were cloned and sequen...