Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

• Published in: Brain (London, England : 1878) Vol. 137; no. 9; pp. 2493 - 2508
• Main Authors: Hall, Hélène, Reyes, Stefanie, Landeck, Natalie, Bye, Chris, Leanza, Giampiero, Double, Kay, Thompson, Lachlan, Halliday, Glenda, Kirik, Deniz
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2014
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Choline O-Acetyltransferase - metabolism; Cholinergic Neurons - enzymology; Cholinergic Neurons - pathology; Clinical Medicine; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus - enzymology; Hippocampus - pathology; Humans; Klinisk medicin; Lewy Body Disease - diagnosis; Lewy Body Disease - enzymology; Lewy Body Disease - psychology; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurologi; Neurology; Parkinson Disease - diagnosis; Parkinson Disease - enzymology; Parkinson Disease - psychology; Cholinergic neuron; Nervous system diseases; Parkinson's disease; Central nervous system; Parkinson disease; Encephalon; Cerebral disorder; Lewy bodies; cholinergic neurons; Anatomic pathology; Dysfunction; Central nervous system disease; dopaminergic neurons; Dopaminergic neuron; Degenerative disease; Hippocampus; Extrapyramidal syndrome; Lewy body; Dementia; dementia; Parkinson’s disease

The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies ha...