Structural insights into FSP1 catalysis and ferroptosis inhibition

• Published in: Nature communications Vol. 14; no. 1; pp. 5933 - 13
• Main Authors: Lv, Yun, Liang, Chunhui, Sun, Qichao, Zhu, Jing, Xu, Haiyan, Li, Xiaoqing, Li, Yao-yao, Wang, Qihai, Yuan, Huiqing, Chu, Bo, Zhu, Deyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.09.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 101/58; 631/45/173; 631/535/1266; 631/80/82; 82/1; 82/16; 82/80; 82/83; Apoptosis; Apoptosis-inducing factor; Binding; Biology; Catalysis; Catalytic activity; Chromatography; Dehydrogenases; Dimerization; Drug development; Ferroptosis; Glutathione; Humanities and Social Sciences; Hydrogen peroxide; Hydroxylation; Medical schools; Medicine; multidisciplinary; Nicotinamide adenine dinucleotide; Science; Science (multidisciplinary); Substrates; Ubiquinone

Ferroptosis suppressor protein 1 (FSP1, also known as AIMF2, AMID or PRG3) is a recently identified glutathione-independent ferroptosis suppressor 1 – 3 , but its underlying structural mechanism remains unknown. Here we report the crystal structures of Gallus gallus FSP1 in its substrate-free and ub...