Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia

• Published in: Schizophrenia bulletin Vol. 46; no. 4; pp. 937 - 946
• Main Authors: Koshiyama, Daisuke, Kirihara, Kenji, Tada, Mariko, Nagai, Tatsuya, Fujioka, Mao, Usui, Kaori, Araki, Tsuyoshi, Kasai, Kiyoto
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08.07.2020
• Subjects: Adaptation, Physiological - physiology; Adult; Auditory Perception - physiology; Biomarkers; Electroencephalography; Evoked Potentials, Auditory - physiology; Female; Humans; Male; Perceptual Disorders - etiology; Perceptual Disorders - physiopathology; Regular; Schizophrenia; Schizophrenia - complications; Schizophrenia - physiopathology; Young Adult; adaptation; schizophrenia; mismatch negativity (MMN); translatable physiological biomarker; deviance detection

The auditory mismatch negativity (MMN) is a translatable electroencephalographic biomarker automatically evoked in response to unattended sounds that is robustly associated with cognitive and psychosocial disability in patients with schizophrenia. Although recent animal studies have tried to clarify...