Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study

• Published in: Journal of headache and pain Vol. 24; no. 1; pp. 112 - 14
• Main Authors: Bi, Yaodan, Zhu, Yinchao, Tang, Shuai, Huang, Yuguang
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 18.08.2023; Springer Nature B.V; BMC
• Subjects: Apolipoprotein B; Apolipoproteins; Cholesterol; Datasets; Drug development; Drug target Mendelian randomization; Dyslipidemia; Genetic analysis; Genetic diversity; Genetic factors; Headache; High density lipoprotein; Internal Medicine; Lipids; Low density lipoprotein; Medicine; Medicine & Public Health; Migraine; Mimicry; Neurology; Pain Medicine; Pleiotropy; Quantitative trait loci; Sensitivity analysis; Statins; Statistical analysis; Therapeutic targets; Drug target Mendelian randomization; Lipids; Migraine

Introduction Migraine, a prevalent headache disorder with unclear mechanisms and limited treatments, may be influenced by dyslipidemia and genetic factors. Statins and emerging lipid-modifying agents show potential but lack evidence for migraine management. Mendelian Randomization analysis offers in...