Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles

• Published in: Scientific reports Vol. 13; no. 1; p. 18472
• Main Authors: Du, Lixin, Lu, Huiling, Xiao, Yifei, Guo, Zhihua, Li, Ya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/45; 639/925; 692/308; Bioavailability; Drug delivery; Evaporation; Ginsenosides; Humanities and Social Sciences; multidisciplinary; Nanoparticles; Pharmacokinetics; Polylactide-co-glycolide; Science; Science (multidisciplinary); Zeta potential

This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the resulting Ginsenoside Rb1-PLGA Nanoparticles (GRb1@PLGA@NPs). GRb1@PLGA@NPs were prepared using the emulsion solvent evaporation method. The optimal prepara...